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JAK-STAT

SAMHD1 Research Digest — 2026-07-29

Generated by samhd1_monitor | Model: claude-sonnet-5

Summary: 12 papers evaluated | 3 high-relevance (≥7) | 8 medium (5–6) | 1 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Auto-added to Zotero (threshold ≥6)

Mitophagy mitigates mitochondrial DNA-induced activation of cGAS-STING in autoimmune thyroiditis (from Endocrinology/Rheumatology—autoimmune thyroiditis model provides orthogonal evidence for cGAS-STING-driven tissue-specific autoimmunity that bridges to systemic interferonopathy phenotype in multi-system SAMHD1 families.)
Xiao-Chen Xie; Yang Guo; Ran Guo; Yong-Ze Li; Shan-Shan Wang — Nature Communications 2026
Score: 8/10 | Pathways: cGAS-STING, VDAC1, ISG15-mitophagy, POLG-mtDNA, mito-ROS-NF-kB, treatment-target, clinical-phenotype

Directly demonstrates mtDNA-cGAS-STING axis driving autoimmune disease via impaired mitophagy (PINK1/Parkin/TAX1BP1), mechanistically overlapping with the RED and BLUE loops in SAMHD1 A565T haploinsufficiency; identifies STING inhibition as therapeutic target applicable to convergent interferonopathy.
DOI: 10.1038/s41467-026-76047-9

NLRP3 Inhibitor KBD3536 Attenuates Acute Inflammation, Radiation-Induced Skin Injury, and Early Metabolic Dysfunction in Preclinical Models. (from Pharmacology/medicinal chemistry (NLRP3 inhibitor drug discovery and preclinical efficacy testing))
Qian Xinying; Ye Fei; Li Zhiyong; Chu Hongzhu; Xu Zeng — Pharmaceuticals (Basel, Switzerland) 2026
Score: 7/10 | Pathways: urate-NLRP3, NLRP3, NF-kB-IKK, treatment-target, clinical-phenotype

KBD3536 is a novel NLRP3 inhibitor with demonstrated efficacy in MSU-induced acute inflammation (gouty arthritis) and HFD-induced metabolic dysfunction—two pathologies directly implicated in the SAMHD1 A565T family phenotype (dGTP → purine catabolism → uric acid → MSU-NLRP3 axis; hepatic steatosis via IRF7-metabolic reprogramming); the paper provides preclinical validation of NLRP3 inhibition as a therapeutic strategy for this converged interferonopathy-metabolic syndrome.
DOI: 10.3390/ph19071083

CRISPR screening identifies GNPTAB as a noncanonical STING activator driving cellular senescence. (from Cell biology/gerontology—lysosomal biology and senescence mechanotransduction, not traditionally part of immunology or rheumatology training.)
Yin Jian; Gao Yizhou; Jing Yaobin; Jiang Xiaoyu; Wang Feibo — Protein & cell 2026
Score: 7/10 | Pathways: cGAS-STING, NF-kB-IKK, mTOR-lysosomal, treatment-target

GNPTAB-STING noncanonical activation via direct protein-protein interaction (E1119 interface) provides a novel upstream STING priming mechanism independent of canonical cGAS-mtDNA sensing; this represents an alternative route to STING/TBK1/NF-κB axis hyperactivation relevant to the BLUE and NF-κB crosstalk loops in A565T interferonopathy, with actionable therapeutic potential (STING-GNPTAB interface antagonism) for suppressing senescence-associated STING amplification.
DOI: 10.1093/procel/pwag049

🟡 Medium Relevance (Score 5–6)

Score ≥6 auto-added to Zotero; lower scores: review manually

DNAJB12/14 redox switching directs chaperone- and Bax/Bak-dependent ER protein reflux. (from Cell biology / ER stress and proteostasis; redox biochemistry)
Abu Madegam Laila; Gavriel Noa; Adebisi Raifu Tolulope; Igbaria Aeid — Redox biology 2026
Score: 6/10 | Pathways: BIK-cancer, mTOR-lysosomal, NF-kB-IKK, apoptosis-autophagy switch

BIK-mediated BAX/BAK recruitment to ER during severe ER stress mechanistically overlaps with the apoptosis-autophagy switch dysregulated in SAMHD1 haploinsufficiency, where ISGylation of BH3-only proteins and mitochondrial damage drive cell death; redox-sensitive DNAJB chaperone control of proteostasis and ER-to-cytosol signaling may modulate the severity of interferonopathy-driven ER stress in this family.
DOI: 10.1016/j.redox.2026.104324

Pectolinarigenin Attenuates LPS-Induced Lung Inflammation and Injury with Reduced HDAC3/NF-κB/NLRP3 Signaling. (from Pulmonology/immunotoxicology; plant natural products pharmacology)
Kim Danbee; Lee Dong-Keon; Park Jeong-Ran — Antioxidants (Basel, Switzerland) 2026
Score: 6/10 | Pathways: NLRP3, NF-kB-IKK, NF-kB-NLRP3-priming, treatment-target

Pectolinarigenin directly modulates the HDAC3/NF-κB/NLRP3 axis in LPS-induced inflammation, addressing two key steps in the proband's pathophysiology: NF-κB transcriptional priming of NLRP3 (Signal 1) and NLRP3 inflammasome activation (Signal 2); HDAC3 inhibition is a mechanistically novel approach to breaking the NF-κB–NLRP3 feed-forward loop and reducing mitochondrial ROS-driven inflammation, though the study uses acute LPS challenge rather than the chronic mitochondrial dNTP–oxMtDNA–NLRP3 circuit specific to SAMHD1 haploinsufficiency.
DOI: 10.3390/antiox15070898

Evolutionary history and recombination in the mitochondrial carrier SLC25 superfamily analyzed by similarities in the exon and transmembrane α‐helix sequences (from Evolutionary biology / structural proteomics)
Magnus Monné; D. V. Miniero; R. Calvello; A. Cianciulli; Luigi Palmieri — Protein Science : A Publication of the Protein Society 2026
Score: 6/10 | Pathways: mito-dNTP-transport, nucleotide-rewiring, other

This evolutionary/structural analysis of SLC25 superfamily (including PNC1/PNC2 nucleotide carriers) provides mechanistic foundation for understanding how substrate-specific subfamilies arose, directly relevant to the PNC1/2-mediated mitochondrial dNTP import bypass that drives NLRP3 hyperactivation in SAMHD1 haploinsufficiency; exon recombination patterns could illuminate functional specialization of dNTP transporters.
DOI: 10.1002/pro.70727

Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. (from Synthetic optogenetics/photobiology—a tool discipline offering potential mechanistic insight and future targeting strategy for the NF-κB and interferon regulatory axis but without direct mitochondrial, dNTPase, or disease-specific validation.)
Leopold Anna V; Verkhusha Vladislav V — Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026
Score: 6/10 | Pathways: NF-kB-IKK, IRF7-metabolic, treatment-target

Synthetic TLR optogenetics with MyD88→NF-κB/IRF3/IRF7 axis reprogramming is mechanistically adjacent to the NF-κB priming of NLRP3 and the dual IKKε-driven NF-κB + IRF7 crosstalk that sustains the convergent interferon–mitochondrial syndrome in SAMHD1 p.A565T haploinsufficiency; optical dissection of TLR→MyD88→NF-κB/IRF signaling could reveal druggable nodes in the IKK-NEMO complex and IRF7-metabolic amplification loop.
DOI: 10.1002/advs.202520640

Targeting the NLRP3/Caspase-1 pyroptotic pathway exacerbates insulin resistance upon exposure to nanoplastics with different surface chemistries. (from Environmental toxicology and metabolic disease; bridges to rare disease through convergent NLRP3-inflammasome-insulin-resistance axis and mitochondrial dysfunction phenocopy of SAMHD1 haploinsufficiency.)
Yao Xinxin; Cao Yu; Lin Sue; Chen Shihua; Xie Feiqin — Journal of hazardous materials 2026
Score: 6/10 | Pathways: NLRP3, mitochondrial-ROS-NF-kB, oxidative-stress-mtDNA, metabolic-dysfunction-insulin-resistance, inflammasome-pyroptosis, other

Paper demonstrates NLRP3/caspase-1 pyroptotic activation downstream of nanoplastic-induced mitochondrial dysfunction and cytosolic mtDNA accumulation in metabolic stress (hyperglycemia/insulin resistance), directly modeling the PURPLE-loop mechanism (ox-mtDNA → NLRP3) and BLUE-loop (mtDNA escape → inflammasome) operative in SAMHD1 A565T haploinsufficiency; validates NLRP3 inhibition as partial rescue strategy for metabolic phenotypes, but lacks SAMHD1, dNTPase, or dNTP-mediated mechanism, and uses exogenous environmental trigger rather than genetic haploinsufficiency.
DOI: 10.1016/j.jhazmat.2026.143078

Astilbin Alleviates Gouty Arthritis via Regulating NLRP3 Inflammasome and NF-κB Signaling Pathway: A Comprehensive Study on In Vitro and In Vivo Experimental Models. (from Rheumatology/Pharmacology (natural product anti-inflammatory); mechanism-of-action study demonstrating dual NLRP3–NF-κB inhibition in gouty arthritis model, transferable to dNTP-driven NLRP3 hyperactivation in SAMHD1-deficient states.)
Zhang Xiaoxi; Fu Gaoyang; Zhao Xinyu; Huang Yan; Li Fenfen — Nutrients 2026
Score: 6/10 | Pathways: urate-NLRP3, NLRP3, NF-kB-IKK, NF-kB-NLRP3-priming, treatment-target

Astilbin suppresses MSU-crystal–induced NLRP3 inflammasome and NF-κB signaling (P-p65, P-IKKα, P-IκBα, cleaved-caspase-1), directly targeting the GOLD pathway (dGTP → uric acid → MSU → NLRP3) and the NF-κB priming axis that sustains IL-1β autocrine amplification in SAMHD1 haploinsufficiency; relevant as a potential adjunctive therapeutic for the inflammatory arm of convergent interferon–mitochondrial syndrome in this family.
DOI: 10.3390/nu18142360

Blood transcriptome bridges orthogonal immunotypes and gut microbiome enterotypes in humans. (from Microbiome/Metabolomics)
Affaticati Fabio; Ha My K; Gehrmann Thies; De Boeck Ilke; Kuznetsova Mariia — Cell reports 2026
Score: 6/10 | Pathways: NF-kB-IKK, JAK-STAT, NLRP3, clinical-phenotype

Blood transcriptome integration identifies two distinct inflammatory profiles—interferon-driven versus NF-κB/IL-6-driven—that directly map to the divergent activation streams (BLUE interferon loop vs. PURPLE/GOLD NLRP3 loops) in SAMHD1 A565T haploinsufficiency; gut microbiota-immune axis bridging is relevant to family's reported gastrointestinal heterogeneity and immunotype stratification in interferonopathy populations.
DOI: 10.1016/j.celrep.2026.117752

Evaluation of Zebularine as a Potential DNA Methyltransferase 1 Inhibitor Associated With SAMHD1 Expression in Cancer Cells (from Oncology)
Muhammad Zeeshan Ahmed; Mahnoor Fatima; Ayesha Shahbaz; Zeeshan Mutahir — ChemistrySelect 2026
Score: 5/10 | Pathways: BIK-cancer, SAMHD1, treatment-target

Zebularine modulates SAMHD1 expression in prostate cancer cells (relevant to BIK-prostate axis and SAMHD1 as tumor suppressor in family phenotype), but mechanistic connection is via DNMT1 epigenetic silencing rather than dNTPase activity, mitochondrial dysfunction, or interferonopathy pathways central to A565T haploinsufficiency.
DOI: 10.1002/slct.73893

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

VRK3 promotes KSHV infection by suppressing the antiviral type I interferon response. (from Virology/Oncology (KSHV tropism and persistent infection pathogenesis, not immunometabolic or rare disease))
Yu Caroline J; Damania Blossom — PLoS pathogens 2026
Score: 3/10 | Pathways: IRF3, cGAS-STING, JAK-STAT, other

VRK3 suppresses IRF3 and TBK1 activation in KSHV infection, which intersects the cGAS-STING→IRF3→IFN-I axis (BLUE Loop), but lacks SAMHD1 involvement, mitochondrial pathology, dNTP metabolism, NLRP3, or direct relevance to the A565T haploinsufficiency mechanism driving the convergent interferon–mitochondrial syndrome.
DOI: 10.1371/journal.ppat.1014400

Pathway Coverage This Week

  • treatment-target: 7 papers
  • NF-kB-IKK: 7 papers
  • NLRP3: 5 papers
  • cGAS-STING: 3 papers
  • clinical-phenotype: 3 papers
  • other: 3 papers
  • urate-NLRP3: 2 papers
  • mTOR-lysosomal: 2 papers
  • BIK-cancer: 2 papers
  • NF-kB-NLRP3-priming: 2 papers
  • JAK-STAT: 2 papers
  • VDAC1: 1 papers
  • ISG15-mitophagy: 1 papers
  • POLG-mtDNA: 1 papers
  • mito-ROS-NF-kB: 1 papers
  • apoptosis-autophagy switch: 1 papers
  • mito-dNTP-transport: 1 papers
  • nucleotide-rewiring: 1 papers
  • IRF7-metabolic: 1 papers
  • mitochondrial-ROS-NF-kB: 1 papers
  • oxidative-stress-mtDNA: 1 papers
  • metabolic-dysfunction-insulin-resistance: 1 papers
  • inflammasome-pyroptosis: 1 papers
  • SAMHD1: 1 papers
  • IRF3: 1 papers

↩ Re-run 08:33 UTC | Model: claude-sonnet-5

Summary: 1 new papers | 0 high-relevance (≥7) | 1 medium (5–6) | 0 low (3–4)

🟡 Medium Relevance

Multiple Roles of G3BP1 in Regulating STING-Dependent Interferon and Cytokine Induction by Cytosolic dsDNA and HSV-1 Infection. (from Virology/cell stress biology)
Trupti Devale; Praveen Manivannan; K. Malathi — Viruses 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

Details G3BP1 as a regulator of cGAS-STING signaling (STING Golgi trafficking, IFN/cytokine output) directly relevant to the BLUE loop mechanism underlying the SAMHD1 interferonopathy, though it does not involve SAMHD1 itself.
DOI: 10.3390/v18070719

SAMHD1 Research Digest — 2026-07-26

Generated by samhd1_monitor | Model: claude-sonnet-5

Summary: 31 papers evaluated | 5 high-relevance (≥7) | 16 medium (5–6) | 10 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Auto-added to Zotero (threshold ≥6)

Modeling calcific aortic valve disease with engineered human valve tissues identifies SAMHD1 as a therapeutic target. (from Cardiology/bioengineering (tissue engineering and valvular calcification))
Meng Xiangfu; Zhou Qian; Zhu Zijin; Qiao Weihua; Geng Bingchuan — Biomaterials 2026
Score: 7/10 | Pathways: treatment-target, clinical-phenotype, other

This paper identifies SAMHD1 as a novel therapeutic target in calcific aortic valve disease via WGCNA-driven small-molecule inhibition, extending SAMHD1's disease relevance beyond interferonopathy into a cardiovascular/osteogenic context pertinent to potential cardiac phenotypes in the family.
DOI: 10.1016/j.biomaterials.2026.124432

The mitochondrial DNA signal in rheumatoid arthritis: From metabolic victim to inflammatory driver. (from Rheumatology)
Zhang Ruoyi; Song Zhijie; Xin Qimeng; Xing Wenbin; Zhang Wenlan — Biochemical and biophysical research communications 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, POLG-mtDNA, clinical-phenotype, treatment-target

Reviews the mtDNA damage-release-cGAS/STING-NLRP3 axis driving RA inflammation, mechanistically parallel to the purple/blue loops in the SAMHD1 syndrome and directly relevant to the family's rheumatoid arthritis phenotype.
DOI: 10.1016/j.bbrc.2026.154304

Case of Aicardi-Goutières syndrome diagnosed in adulthood on whole-genome sequencing. (from Neurology/Genetics)
Cobb Lewis; Kumar Jayant; Roy Amit; Walsh Sarah; Sheerin Una-Marie — BMJ neurology open 2026
Score: 7/10 | Pathways: AGS-spectrum, cGAS-STING, JAK-STAT, treatment-target, clinical-phenotype

This adult-diagnosed ADAR-related AGS case with atypical presentation, cardiac calcification, and baricitinib consideration directly parallels the type I interferonopathy spectrum and JAK inhibitor treatment strategy relevant to SAMHD1-driven disease.
DOI: 10.1136/bmjno-2025-001407

HTLV-1 Tax induces PINK1-PRKN/parkin-dependent mitophagy to mitigate activation of the CGAS-STING1 pathway. (from Virology/hematology (HTLV-1-associated leukemia and neuroinflammatory disease))
Mohanty Suchitra; Suklabaidya Sujit; Mnatsakanyan Nelli; Jacobson Steven; Harhaj — Autophagy 2026
Score: 7/10 | Pathways: cGAS-STING, ISG15-mitophagy, NF-kB-IKK, treatment-target

This paper demonstrates PINK1-PRKN-dependent mitophagy (via NEMO/IKK interaction) suppressing cGAS-STING1-driven type I interferon activation in a viral infection context, directly paralleling the mitophagy-block/IFN-I-amplification mechanism central to the SAMHD1 syndrome model (RED/BLUE loops) even though the driver here is HTLV-1 Tax rather than SAMHD1 dysfunction.
DOI: 10.1080/15548627.2026.2707897

Type I interferonopathies: 15 years after the concept-news and views. (from Rheumatology)
S. Khaldi-Plassart; I. Melki; M. Frémond — Current opinion in rheumatology 2026
Score: 7/10 | Pathways: cGAS-STING, AGS-spectrum, treatment-target, clinical-phenotype, JAK-STAT

This review covers type I interferonopathy mechanisms (STING/IFNAR signaling, TLR pathways, clinical penetrance variability, JAK inhibitor therapeutics) directly relevant to the SAMHD1-driven IFN-I overproduction and AGS-spectrum disorder underlying the family syndrome, though it does not address SAMHD1 specifically.
DOI: 10.1097/BOR.0000000000001179

🟡 Medium Relevance (Score 5–6)

Score ≥6 auto-added to Zotero; lower scores: review manually

Fibroblast S1PR2 Amplifies NLRP3 Inflammasome Activation Under Pressure Overload. (from Cardiology)
Zhou Caixia; Liu Zhihao; Wang Zhiru; Cui Zekun; Wang Qian — Hypertension (Dallas, Tex. : 1979) 2026
Score: 6/10 | Pathways: NLRP3, mito-ROS-NF-kB, treatment-target

Demonstrates mitochondrial damage (DRP1 fission, mitophagy suppression) driving mtDNA leakage and NLRP3 activation, mechanistically parallel to the SAMHD1 mitochondrial-inflammasome axis though in cardiac fibroblasts rather than SAMHD1-deficient immune cells.
DOI: 10.1161/HYPERTENSIONAHA.126.27475

Isoalantolactone targets NLRP3 to disrupt NLRP3-NEK7 interaction and suppress inflammasome activation. (from pharmacology/drug discovery)
Shi Yuanfang; Zhu Xiaoyun; Sun Meng; Yang Yang; Lin Siwei — Biochemical pharmacology 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, treatment-target

This paper identifies a small-molecule NLRP3 inhibitor effective against MSU-induced gout and MASLD, directly relevant to the GOLD pathway (dGTP→uric acid→MSU→NLRP3) and offering a potential therapeutic candidate for the syndrome's inflammasome-driven pathology.
DOI: 10.1016/j.bcp.2026.118165

Interferon-related gene expression defines disease activity, organ involvement and treatment response in juvenile dermatomyositis. (from Pediatric rheumatology (juvenile dermatomyositis))
Codes-Méndez Helena; Cuyx Senne; Syntakas Aris E; Barmpakou Afroditi; Moraitis E — Rheumatology (Oxford, England) 2026
Score: 6/10 | Pathways: JAK-STAT, treatment-target, clinical-phenotype

Demonstrates type-I interferon-related gene expression (ISGs, IFI27, IFI44L, RSAD2) as biomarker of disease activity and JAK inhibitor (baricitinib) response, directly reinforcing the IFN-I/JAK-STAT arm of the interferonopathy mechanism relevant to SAMHD1 pathway and treatment translation, though not SAMHD1-specific.
DOI: 10.1093/rheumatology/keag384

Glycerol-3-Phosphate Attenuates Hypoxic-Ischemic Brain Injury via Modulation of Microglia-Mediated Neuroinflammation. (from Neurology/perinatal neonatology)
Qin Dani; Lei Yong; Le Meini; Cheng Mengke; Zhao Yingmin — Neurochemical research 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target, mito-ROS-NF-kB

Demonstrates cGAS-STING-TBK1-NF-kB axis driving microglial neuroinflammation and mitochondrial dysfunction, directly relevant to the same core pathway implicated in the SAMHD1 A565T interferon-mitochondrial syndrome, with therapeutic implications for neuroinflammatory phenotypes seen in the family (AuDHD, ME/CFS-like fatigue).
DOI: 10.1007/s11064-026-04848-x

Aspirin Inhibits the cGAS-STING Signaling Pathway to Ameliorate the Development of Aortic Aneurysm and Dissection. (from Vascular surgery/cardiology (aortic aneurysm and dissection))
Zeng Yi-Fan; Wang Qiu-Guo; Qi Zhen; Li Jing-Yu; Duan Zhi-Cheng — Arteriosclerosis, thrombosis, and vascular biology 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

Demonstrates a novel cGAS-STING axis (via cGAS acetylation) driving mitochondrial/ferroptotic vascular pathology and its pharmacological inhibition by aspirin, directly relevant to the Blue loop mechanism though in a cardiovascular rather than immune context.
DOI: 10.1161/ATVBAHA.126.324930

Single-Cell Analysis of Residual Esophageal Squamous Cell Carcinoma After Neoadjuvant Immunochemotherapy Reveals TFAM-Mediated Immunoregulation in Dendritic Cells. (from Oncology (esophageal squamous cell carcinoma immunotherapy))
Chen Linyan; Feng Tang; Zhou Jianfeng; Zeng Hao; Lai Yutian — Cancer research 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, other

This paper demonstrates TFAM deficiency in dendritic cells activating the STING-TBK1-IRF3 pathway to promote anti-tumor immunity, directly relevant to the mitochondrial-cGAS-STING-IFN-I axis central to the SAMHD1 mechanism though in an oncologic rather than interferonopathy context.
DOI: 10.1158/0008-5472.CAN-25-4738

Stub1 promotes chaperone-mediated autophagy to suppress antiviral immunity. (from Virology/cell biology (autophagy regulation))
Liu Hongyang; Huang Li; Weng Changjiang — Autophagy 2026
Score: 6/10 | Pathways: cGAS-STING, JAK-STAT, treatment-target

This paper describes a novel TBK1 degradation pathway (CMA via Stub1) that directly regulates the cGAS-STING-TBK1-IFN-I axis central to the SAMHD1 mechanism, relevant to interferonopathy modulation though not SAMHD1-specific.
DOI: 10.1080/15548627.2026.2667376

Dual-regulation of mitophagy and cytosolic mtDNA-induced inflammation for the treatment of inflammatory bone loss. (from orthopedics/bone regeneration)
Zheng Kaiwen; Che Benchi; Cui Yongzhi; Yang Han; Xiang Yu — 2026
Score: 6/10 | Pathways: cGAS-STING, ISG15-mitophagy, treatment-target, clinical-phenotype

Directly models the mtDNA-cGAS-STING-inflammation-mitophagy (PINK1) axis central to the BLUE/RED streams and demonstrates a dual STING/PINK1 exosome therapeutic, relevant to osteoporosis noted in family phenotype tracking though not SAMHD1-specific.
DOI: 10.1016/j.freeradbiomed.2026.07.031

Tumor microenvironment-responsive manganese nanoplatform amplifies cGAS-STING via metabolic-metal synergy for immunotherapy. (from Oncology/nanomedicine)
Zhou Yanlin; Wu Ziyi; Zheng Tao; Luo Shunhong; Zhang Lu — 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

Demonstrates mitochondrial fragmentation-driven mtDNA leakage activating cGAS-STING (mirroring the BLUE/VDAC1 loop) in an oncology nanomedicine context, offering mechanistic and therapeutic parallels though not SAMHD1-specific.
DOI: 10.1016/j.jconrel.2026.115197

Mitochondria-targeted MXene-based nanozymes promote mitophagy and inhibit mtDNA-triggered cGAS/STING inflammation in osteoarthritis. (from Orthopedics/Nanomedicine)
Li Tiancheng; Zheng Ao; Zhu Cheng; Li Yixin; Yang Zitong — 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

Demonstrates a nanozyme therapeutic that restores mitophagy and blocks mtDNA-driven cGAS/STING inflammation, directly reinforcing the disease model's Loop A mechanism though in an unrelated joint disease context.
DOI: 10.1016/j.bioactmat.2026.07.010

Engineering-Modulated Molybdenum Enzymes Strategy for Tumor-Specific Metabolic-Immunotherapy. (from oncology/nanomedicine)
Pan Xiaoxiao; Pei Zifan; Wu Jie; Jiang Nan; Li Qian — 2026
Score: 6/10 | Pathways: cGAS-STING, urate-NLRP3, treatment-target

This oncology nanomedicine paper demonstrates mtDNA release activating cGAS-STING and purine metabolism driving uric acid elevation as an immune activator, mechanistically paralleling the PURPLE/GOLD and BLUE streams (dGTP-uric acid-MSU-NLRP3 and mtDNA-cGAS-STING) in the SAMHD1 syndrome despite being applied in a cancer immunotherapy context.
DOI: 10.1002/advs.76726

Phase-dependent dynamics of circulating cell-free mitochondrial DNA reflect distinct immunometabolic states (from Tropical medicine/infectious disease and pediatric cardiac surgery biomarker research)
Karen Alessandra Rodrigues; Emilly Henrique dos Santos; Gabriel Acca Barreira; M — Revista do Instituto de Medicina Tropical de São Paulo 2026
Score: 6/10 | Pathways: VDAC1, NLRP3, treatment-target, clinical-phenotype

Circulating cell-free mtDNA as a DAMP driving innate immune activation is directly relevant to the BLUE/PURPLE mitochondrial escape and NLRP3 activation loops central to the SAMHD1 interferon-mitochondrial syndrome, though it does not address SAMHD1 itself.
DOI: 10.1590/s1678-9946202668048

Severe Antenatal Presentation of a Novel Dnase2 Mutation in a Preterm Omani Neonate: Expanding the Clinical Spectrum of an Ultra-Rare Interferonopathy (from Neonatology/Pediatric Genetics)
Ruqaiya Al Jashmi; Marya Al Barumi; S. Al Abrawi; Alyaa Al Mughairy; Aiman Al Ja — Cureus 2026
Score: 6/10 | Pathways: cGAS-STING, JAK-STAT, AGS-spectrum, clinical-phenotype, pregnancy-fetal, treatment-target

DNASE2 deficiency is a type I interferonopathy in the same AGS-spectrum family of diseases as SAMHD1 mutations, sharing cGAS-STING-driven IFN-I pathology and JAK inhibitor responsiveness, with fetal/neonatal presentation relevant to the pregnancy-interferonopathy phenotype tracking axis.
DOI: 10.7759/cureus.111043

Sex-specific differences of amlexanox in a mouse model for atherosclerosis and MASLD. (from Cardiometabolic/hepatology research on IKKε inhibition)
Mungo Eleonora; Haß Michelle; Benning Denis; Schmid Tobias; Kuntschar Silvia — Molecular metabolism 2026
Score: 5/10 | Pathways: NF-kB-IKK, clinical-phenotype

IKKε (a kinase explicitly named in the NF-κB crosstalk mechanism as dual NF-κB/IRF3 activator) is targeted pharmacologically here, showing sex-specific metabolic/inflammatory effects on MASLD and atherosclerosis, relevant background to the IKKβ/IKKε axis but without SAMHD1 or interferon pathway data.
DOI: 10.1016/j.molmet.2026.102426

Editing Around the Target: Epitope Engineering to Protect Stem Cell Grafts. (from Gene therapy/hematology-oncology)
Baek Joanne; Casirati Gabriele; Genovese Pietro; Gill Saar I — Blood advances 2026
Score: 5/10 | Pathways: prime-editing, gene-therapy-delivery

Reviews base/prime editing epitope engineering in HSPCs, relevant as a generic delivery/correction platform potentially applicable to correcting SAMHD1 missense variants in myeloid cells but not disease-specific.
DOI: 10.1182/bloodadvances.2025018227

Efficient CRISPR/Cas9-mediated homology independent sequence replacement in vivo and non-dividing primary cells (from genome editing / gene therapy engineering)
Dang Tu Ngoc; Roman Alexandra; Zimmer Anja; Lebedin Mikhail; Bahry Ella — preprint (preprint) 2026
Score: 5/10 | Pathways: gene-therapy-delivery, prime-editing

This paper describes a novel homology-independent CRISPR/Cas9 sequence replacement platform (REPLACE) using eVLP/AAV delivery in non-dividing cells, relevant as a general gene correction strategy applicable to correcting missense variants like SAMHD1 A565T though not directly tested on it.
DOI: 10.64898/2026.07.24.740048

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

Alopecia areata: Mechanisms, targeted therapies, and translational challenges. (from Dermatology)
Kumar Virender; Sahoo Saurabh; Kumar Pawan — Current opinion in pharmacology 2026
Score: 4/10 | Pathways: JAK-STAT, treatment-target

AA pathogenesis and JAK inhibitor therapy (baricitinib) overlap mechanistically with the IFN-I/JAK-STAT axis relevant to SAMHD1 interferonopathy, but the paper is otherwise unrelated to SAMHD1 or mitochondrial-inflammasome mechanisms.
DOI: 10.1016/j.coph.2026.102635

Gene therapy approaches for inborn errors of immunity: from bench to bedside. (from gene therapy/genetic medicine)
Dara Jasmeen; Booth Claire — Expert opinion on biological therapy 2026
Score: 4/10 | Pathways: gene-therapy-delivery

General review of gene therapy for inborn errors of immunity (retroviral, lentiviral, CRISPR, base/prime editing) provides background relevance to future correction strategies for SAMHD1 variants but has no disease-specific or mechanistic content.
DOI: 10.1080/14712598.2026.2710870

Mitochondrial stress-induced cuproptosis: a metabolic bridge to reprogramming the GBM immune microenvironment. (from Oncology (neuro-oncology/GBM immunotherapy))
Li Wenyang; Lv Yaqing; Wang Guanrong; Lan Xiaolei; Ren Leina — 2026
Score: 4/10 | Pathways: cGAS-STING, other

Discusses mtDNA release triggering cGAS-STING/type I IFN in GBM cuproptosis context, sharing a core mechanistic node but unrelated to SAMHD1 dNTPase biology or the family phenotype spectrum.
DOI: 10.1007/s13402-026-01254-x

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation (from Neurology/gene therapy)
Tianshan Ji; Yuan Zhang; Jinyi Zhao; Yi Lu; Chengkun Wang — Neuroprotection 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

General review of prime editing for neuropsychiatric monogenic disorders offers relevant delivery/technology context but no direct SAMHD1, immune, or mitochondrial pathway content and focuses on neurons rather than myeloid/immune cells.
DOI: 10.1002/nep3.70041

A poly(I:C)/QS-21-based in situ vaccine synergizes with anti-PD-1 therapy to overcome tumor immunoresistance. (from oncology/cancer immunotherapy)
Zhang Wenbo; Ni Xinrui; Zhuo Luoyi; Liu Jiangrui; Yang Guang — Cell reports. Medicine 2026
Score: 3/10 | Pathways: cGAS-STING, treatment-target

This oncology immunotherapy paper touches TBK1-IRF3-type I interferon axis (relevant pathway component) but in a tumor vaccine/anti-PD-1 context unrelated to SAMHD1 haploinsufficiency or the family's interferonopathy syndrome.
DOI: 10.1016/j.xcrm.2026.102932

Gene/Genome Editing in Cardiovascular Biology and Disease. (from Cardiology/gene therapy)
Verma Tushar; Singh Ravi Pratap; Chaudhary Mahima; Sharma Pramod Kumar; Kumar Dh — Current gene therapy 2026
Score: 3/10 | Pathways: prime-editing, gene-therapy-delivery

This is a general cardiovascular gene-editing review with no connection to SAMHD1, interferon-mitochondrial mechanisms, or myeloid/immune cell editing relevant to the family syndrome.
DOI: 10.2174/0115665232453929260206091608

Mitochondrial Communication Networks in the Bone Microenvironment: From the Maintenance of Homeostasis to Translational Interventions for Bone Diseases. (from Orthopedics/bone biology)
Wang Wentao; Wang Kun; Wang Wenjing; Mu Xuan; Cheng Zhiquan — 2026
Score: 3/10 | Pathways: cGAS-STING, other

Bone microenvironment mitochondrial transfer review touches cGAS-STING/mtDNA release but is focused on osteoporosis/osteoarthritis biology largely tangential to SAMHD1 interferonopathy mechanism.
DOI: 10.1007/s12015-026-11190-w

An Insight into the cGAS-STING Pathway Modulation by Metal Complexes to Initiate Immunogenic Cell Death in Cancer. (from medicinal chemistry/oncology)
Shilpendu Ghosh; Sujato Mukherjee; Arindam Mukherjee — Journal of medicinal chemistry 2026
Score: 3/10 | Pathways: cGAS-STING, treatment-target

Discusses cGAS-STING pathway modulation via metal complexes for cancer immunotherapy, mechanistically relevant to Loop A but focused on oncology drug design rather than SAMHD1 or the family syndrome.
DOI: 10.1021/acs.jmedchem.6c00727

Caloric restriction enhances radiosensitivity of colorectal tumors through the cGAS-STING pathway activation. (from Oncology/radiation biology)
Li-Li Zhang; Li-Qiang Qin; Li Ding; Wenyue Shan; Yu Zhao — Cancer & metabolism 2026
Score: 3/10 | Pathways: cGAS-STING

This paper studies cGAS-STING pathway activation via caloric restriction to enhance radiosensitivity in colorectal cancer, sharing a core pathway but in an oncology/radiotherapy context unrelated to SAMHD1 dysfunction, mitochondrial dNTP dysregulation, or the interferonopathy syndrome described.
DOI: 10.1186/s40170-026-00449-y

From convergence to an iterative Optimization-Circumvention-Collapse framework in CRISPR bioengineering (from bioengineering/education)
Federico Filippone-Thaulero — Journal of High School Science 2026
Score: 3/10 | Pathways: prime-editing, gene-therapy-delivery

General theoretical review of CRISPR/base/prime editing trade-offs from a high school science journal, with no immune/myeloid cell specificity or SAMHD1 relevance beyond generic gene-editing correction strategy context.
DOI: 10.64336/001c.165176

Pathway Coverage This Week

  • treatment-target: 21 papers
  • cGAS-STING: 18 papers
  • clinical-phenotype: 9 papers
  • JAK-STAT: 6 papers
  • gene-therapy-delivery: 6 papers
  • prime-editing: 5 papers
  • other: 4 papers
  • NLRP3: 4 papers
  • AGS-spectrum: 3 papers
  • NF-kB-IKK: 3 papers
  • ISG15-mitophagy: 2 papers
  • mito-ROS-NF-kB: 2 papers
  • urate-NLRP3: 2 papers
  • POLG-mtDNA: 1 papers
  • VDAC1: 1 papers
  • pregnancy-fetal: 1 papers

SAMHD1 Research Digest — 2026-07-19

Generated by samhd1_monitor | Model: claude-sonnet-5

Summary: 7 papers evaluated | 0 high-relevance (≥7) | 3 medium (5–6) | 4 low (3–4) | 0 scored <3

🟡 Medium Relevance (Score 5–6)

Score ≥6 auto-added to Zotero; lower scores: review manually

Chirality-dependent toxicity decoupling: Discovery of a resibufogenin-based L-configured STING inhibitor with superior therapeutic profile for ulcerative colitis. (from medicinal chemistry/gastroenterology (ulcerative colitis drug discovery))
Zhuang Jia-Hua; Zhang Qiu-Heng; Zhou Si-Yu; Wen Yuting; Li Yiming — European journal of medicinal chemistry 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

Novel STING inhibitor targeting the STING-TBK1-IRF3-IL-1beta/IL-6/TNF-alpha axis directly relevant to the BLUE loop IFN-I pathway central to this interferonopathy syndrome, though not disease-specific.
DOI: 10.1016/j.ejmech.2026.119146

Biallelic mutations in SUPV3L1 cause a variable leukodystrophy due to impaired mitochondrial degradosome function (from Neurology/neurogenetics (leukodystrophy))
L. Green; Noémie Hamilton; M. Elpidorou; R. Maroofian; Maha S. Zaki — Research Square 2026
Score: 6/10 | Pathways: cGAS-STING, JAK-STAT, AGS-spectrum, clinical-phenotype, other

Describes a distinct mitochondrial nucleic-acid-sensing disorder (mitochondrial dsRNA degradosome dysfunction) converging on type I interferon activation via dysplastic microglia, mechanistically analogous though not identical to the SAMHD1-driven interferonopathy loop (Blue/Red streams).
DOI: 10.21203/rs.3.rs-4356120/v2

Clinical phenotype and laboratory markers in patients affected by haploinsufficiency of A20 (HA20): a case series from two Italian centres (from Rheumatology/pediatric autoinflammatory disease)
Laura De Nardi; Silvia Federici; Eleonora De Martino; Camilla Celani; Martina Gi — RMD Open 2026
Score: 5/10 | Pathways: NF-kB-IKK, clinical-phenotype, AGS-spectrum

A20 (TNFAIP3) haploinsufficiency is a distinct NF-kB-regulatory autoinflammatory disease showing an analogous interferon-signature/NF-kB-driven phenotype with neuropsychiatric comorbidity, offering indirect mechanistic and biomarker parallels to the SAMHD1 interferonopathy-NF-kB axis but no direct SAMHD1 or mitochondrial dNTP data.
DOI: 10.1136/rmdopen-2026-006763

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS–STING pathway: mechanisms, challenges, and combination therapy strategies (from Oncology/radiotherapy)
Yongze He; Xianhu Zeng; Qianyi Liu; Linsen Zhou; Ying Tang — Molecular Cancer 2026
Score: 4/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target

This oncology-focused review discusses cGAS-STING and NF-κB activation via radiotherapy-induced DNA damage in tumors, mechanistically overlapping with the Blue loop but in a distinct clinical context (cancer immunotherapy) not directly tied to SAMHD1 or the interferon-mitochondrial syndrome.
DOI: 10.1186/s12943-026-02634-5

Orally delivered Perilla frutescens-derived nanovesicles regulate the gut-kidney biointerface to attenuate hyperuricemia-associated renal injury. (from Nephrology/gut-kidney axis nutraceutical delivery)
Yang Zhuohang; Yang Siqi; Ran Yi; Zhang Tangqing; Zhang Fen — Colloids and surfaces. B, Biointerfaces 2026
Score: 3/10 | Pathways: urate-NLRP3

The paper touches on the GOLD-stream urate-NLRP3 axis via hyperuricemia-induced renal NLRP3 inflammation, but is a nanovesicle/nephrology-nutraceutical study unrelated to SAMHD1 or the broader interferon-mitochondrial mechanism.
DOI: 10.1016/j.colsurfb.2026.115995

Precision prime editing of TP53 mutations for functional tumor suppression in colorectal cancer. (from Oncology/genome engineering)
Azhar Md; Malviya Rishabha; Chandra Phool; Sridhar Sathvik Belagodu; Shareef Jav — Biochemical and biophysical research communications 2026
Score: 3/10 | Pathways: prime-editing

Discusses prime editing technology for TP53 in colorectal cancer, offering only generic technical relevance to gene correction methods rather than SAMHD1 or immune-mitochondrial mechanisms.
DOI: 10.1016/j.bbrc.2026.154311

Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STING-Mediated Chemoimmunotherapy Inducer that Acts as a Dual Catalytic Inhibitor of Topoisomerase I/II. (from Medicinal chemistry/oncology drug design)
Liang-Mei Yang; Yuan Lu; Matthew S. Levine; Xueqian Wang; Ya-Qian Shi — Journal of the American Chemical Society 2026
Score: 3/10 | Pathways: cGAS-STING

Describes a ruthenium-based chemotherapeutic that activates cGAS-STING for oncologic immunotherapy, sharing a pathway node but with no connection to SAMHD1, mitochondrial dNTP biology, or the family's clinical phenotypes.
DOI: 10.1021/jacs.6c01872

Pathway Coverage This Week

  • cGAS-STING: 4 papers
  • treatment-target: 2 papers
  • AGS-spectrum: 2 papers
  • clinical-phenotype: 2 papers
  • NF-kB-IKK: 2 papers
  • JAK-STAT: 1 papers
  • other: 1 papers
  • urate-NLRP3: 1 papers
  • prime-editing: 1 papers

SAMHD1 Research Digest — 2026-07-18

Generated by samhd1_monitor | Model: claude-sonnet-5

Summary: 35 papers evaluated | 6 high-relevance (≥7) | 17 medium (5–6) | 12 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Auto-added to Zotero (threshold ≥6)

Transition Metal Activation Reframes SAMHD1 Regulation. (from biochemistry/metalloenzyme spectroscopy)
Calderone Logan A; Gizzi Anthony; Pinninti Soumika; Stivers James T; Pandelia Ma — ACS chemical biology 2026
Score: 8/10 | Pathways: dNTPase, treatment-target

This paper directly characterizes the metal cofactor requirements (iron/manganese) for SAMHD1's dNTPase catalytic activity, providing fundamental mechanistic insight into the enzyme whose partial loss-of-function (as in A565T) drives the entire dNTP pool expansion cascade underlying this syndrome.
DOI: 10.1021/acschembio.6c00438

Mitochondrial dynamics and metabolic regulation in cellular inflammation: From mechanisms to precision therapeutics. (from Pharmacology/mitochondrial cell biology)
Park Woo Hyun — Pharmacology & therapeutics 2026
Score: 8/10 | Pathways: NLRP3, cGAS-STING, mito-dNTP-transport, nucleotide-rewiring, treatment-target, VDAC1

Directly engages ox-mtDNA/cGAS-STING/NLRP3 activation via mitochondrial dynamics and explicitly discusses the YME1L-SLC25A33 pyrimidine-imbalance axis, closely paralleling the PNC1/2 nucleotide-carrier mechanism central to the disease model.
DOI: 10.1016/j.pharmthera.2026.109086

MGMT deficiency augments STING-mediated inflammatory responses accompanied by metabolic alterations in macrophages. (from DNA repair biology / cancer genetics)
Kongkavitoon Pornrat; Boonmee Atsadang; Pattarakankul Thitiporn; Wongprom Benjaw — Scientific reports 2026
Score: 7/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target, other

Demonstrates that DNA repair deficiency (MGMT) amplifies STING-TBK1-IRF3 signaling and mitochondrial oxidative metabolism in macrophages, directly relevant to the interferon-mitochondrial crosstalk (cGAS-STING/IRF3, mitochondrial respiration, DNA damage) central to the SAMHD1 syndrome's BLUE/RED loops.
DOI: 10.1038/s41598-026-62431-4

The Development of UM-232, a Covalent STING Antagonist. (from Medicinal chemistry/drug discovery)
Barasa Leonard; DeOrsey Leo; O'Reilly Maeve D; Cahill Sara E; Choudhary Shruti — ACS medicinal chemistry letters 2026
Score: 7/10 | Pathways: cGAS-STING, treatment-target

Describes a novel covalent STING antagonist directly targeting the cGAS-STING axis (Loop A) that drives the IFN-I overproduction central to this SAMHD1 haploinsufficiency syndrome, offering potential therapeutic relevance despite no direct SAMHD1 data.
DOI: 10.1021/acsmedchemlett.6c00114

Electroacupuncture alleviates spinal cord injury by regulating M2-like polarization of myeloid cells through CMPK2/NLRP3 inflammasome inhibition. (from Neurology/Rehabilitation (spinal cord injury, acupuncture))
Zhang Kai; Zhang Mengru; Chen Yi; Ni Ziao; Huang Yi — International immunopharmacology 2026
Score: 7/10 | Pathways: NLRP3, mito-dNTp-transport, nucleotide-rewiring, treatment-target

This paper directly implicates CMPK2 as a regulator of NLRP3 inflammasome activation and myeloid polarization, mechanistically connecting the CMPK2-dependent mitochondrial dNTP salvage pathway (a key node in the SAMHD1/PNC1/PNC2 nucleotide-rewiring model) to NLRP3-driven neuroinflammation, offering a non-obvious cross-context validation of the CMPK2/NLRP3 axis relevant to the SAMHD1 haploinsufficiency mechanism.
DOI: 10.1016/j.intimp.2026.116989

Mitochondrial DNA efflux as a potential amplifier of systemic inflammatory network rewiring in heart failure with preserved ejection fraction (from Cardiology)
Xingwei Zhao; Shengyu Huang; Qiuling Li; Yang Yu; Chunxiang Zhang — Frontiers in Immunology 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, NF-kB-NLRP3-priming, POLG-mtDNA, clinical-phenotype, treatment-target

Describes mtDNA release activating cGAS-STING/TLR9 and NLRP3 inflammasome as a cross-organ inflammatory amplifier, directly paralleling the BLUE/Loop A and NLRP3 priming mechanisms in the SAMHD1 syndrome model though in a cardiology (HFpEF) context rather than SAMHD1-driven disease.
DOI: 10.3389/fimmu.2026.1866184

🟡 Medium Relevance (Score 5–6)

Score ≥6 auto-added to Zotero; lower scores: review manually

Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production. (from pharmacology/drug repurposing)
Li Yuanhao; Xie Qianqian; Sun Tianyin; Lu Jiwei; Li Mengmeng — Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026
Score: 6/10 | Pathways: NLRP3, mito-ROS-NF-kB, urate-NLRP3, treatment-target

Paper details a mitochondrial ROS-dependent NLRP3 activation mechanism (via chloride efflux/TMEM16F) and MSU-crystal-driven inflammasome activation, both directly paralleling the GOLD (urate-NLRP3) and mito-ROS-NF-kB routes in the disease model, with NFA representing a potential adjunct NLRP3-targeting therapeutic.
DOI: 10.1007/s00011-026-02328-0

Targeting CCDC90B restores intestinal stem cell function under hyperuricemic stress. (from Gastroenterology/stem cell biology)
Peng Xiuying; Li Moxuan; Zeng Kaixuan; Lv Wantong; Huang Shuai — Stem cell reports 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, treatment-target

Demonstrates the GOLD-stream mechanism (uric acid → mitochondrial ROS → NLRP3 activation) directly, relevant to the family's SAMHD1-driven dGTP/purine catabolism route to inflammasome activation, albeit in intestinal stem cells rather than immune cells.
DOI: 10.1016/j.stemcr.2026.102970

Ring-finger protein 5 protects against diabetic kidney disease by targeting and degrading STING. (from Nephrology/Endocrinology (diabetic kidney disease))
Dong Chunping; Sun Yan; Li Hui; Qiao Yuan; Gao Shan — Pathology, research and practice 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target

Demonstrates RNF5-mediated ubiquitin degradation of STING suppressing TBK1/IRF3/NF-kB activation and fibrosis in diabetic kidney disease, offering a plausible downstream therapeutic node for the STING/NF-kB arm of the interferon-mitochondrial syndrome despite being in a different clinical context (nephrology/diabetes).
DOI: 10.1016/j.prp.2026.156618

Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches. (from Endocrinology (type 1 diabetes autoimmunity))
Iwaloye Opeoluwa F; Mathews Clayton E; Li Danmeng — Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2026
Score: 6/10 | Pathways: IRF7-metabolic, NF-kB-IKK, treatment-target, clinical-phenotype

MDA5/IFIH1-driven type I interferon signaling via TBK1/IKKε-IRF and NF-κB converges mechanistically with the SAMHD1 cGAS-STING/NF-κB interferonopathy axis and shares therapeutic logic (JAK/IFN pathway targeting) relevant to autoimmune comorbidities in the family phenotype spectrum.
DOI: 10.1177/10799907261467555

Senegenin mitigates neuroinflammation, pyroptosis, and apoptosis in cerebral ischemia via inhibiting STING and downstream inflammatory pathway. (from neurology/stroke pharmacology)
Chauhan Chandan; Kaundal Ravinder K — European journal of pharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, NF-kB-IKK, treatment-target

Demonstrates pharmacological STING-TBK1-IRF3 and NF-κB/NLRP3 pathway inhibition reducing pyroptosis/apoptosis in a disease model, directly relevant to the core Loop A/B mechanism though in an unrelated ischemic stroke context rather than SAMHD1-driven interferonopathy.
DOI: 10.1016/j.ejphar.2026.179147

Dietary riboflavin blocks the cGAS-STING pathway to curb hypoxia-induced hepatic inflammation in sub-adult grass carp (Ctenopharyngodon idella). (from veterinary/aquaculture nutrition science)
Zhong Lin; Feng Lin; Wu Pei; Jiang Weidan; Zhang Hongyun — Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026
Score: 6/10 | Pathways: cGAS-STING, VDAC1, NF-kB-IKK, mito-ROS-NF-kB, treatment-target

This fish study demonstrates VDAC1/mtDNA-driven cGAS-STING-TBK1-IRF3/NF-kB (p-P65) activation causing hepatic inflammation under hypoxia, mirroring the BLUE loop and NF-kB crosstalk mechanisms in the SAMHD1 syndrome, with riboflavin as a mitochondrial-protective therapeutic lever relevant to treatment strategies.
DOI: 10.1016/j.aninu.2026.01.012

Reduced myocardial NRG-1/ErbB4 signaling is associated with STING-linked macrophage pyroptotic signaling in sepsis-induced cardiac injury. (from Cardiology/sepsis)
Wei Yanian; Wang QianWen; Shen Cheng; Pan Xia; Kang Wen — International immunopharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, NF-kB-IKK, treatment-target

This paper demonstrates cGAS-STING-TBK1-IRF3/NF-kB signaling driving macrophage pyroptosis (NLRP3, caspase-1, GSDMD-N) in cardiac injury, directly relevant to the interferon-inflammasome axis and cardiac phenotype seen in the SAMHD1 family, though it lacks any SAMHD1 connection.
DOI: 10.1016/j.intimp.2026.117044

LKB1/ AMPK deficiency aggravates mitochondrial DNA leakage via mTOR-dependent mitophagy damage in liver injury sensitized by trichloroethylene. (from Occupational/environmental toxicology and hepatology)
Zhu Lifu; Wan Chenghuan; Li Zijun; Fan Xuan; Liu Dongsheng — 2026
Score: 6/10 | Pathways: cGAS-STING, mTOR-lysosomal, treatment-target

Demonstrates mitophagy failure leading to mtDNA leakage and cGAS-STING-driven inflammation via LKB1/AMPK/mTOR axis, mechanistically parallel to the mitochondrial-interferon convergence in the SAMHD1 syndrome despite a different toxicological trigger.
DOI: 10.1016/j.cbi.2026.112261

Microglial mitophagy as an immunometabolic checkpoint in alzheimer's disease: linking mitochondrial quality control to neuroinflammation. (from Neurodegeneration/neuroimmunology)
Zou Mingyue; Zhao Tengyu; Wu Weidong; Zhang Jian; Pan Pengyu — 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, ISG15-mitophagy, mTOR-lysosomal, treatment-target

Reviews microglial mitophagy failure driving mtDNA/mtROS-triggered cGAS-STING and NLRP3 activation with TBK1 signaling, mechanistically parallel to the mitochondrial-quality-control/interferon-inflammasome axis central to the SAMHD1 syndrome, though disease context is Alzheimer's rather than SAMHD1.
DOI: 10.1186/s12974-026-03946-5

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart (from Cardio-oncology/pharmacology)
Kelsey H. Fisher-Wellman; Richard D. Lutze; Logan G. Kirkland; J. Beak; Mansi Go — Science Advances 2026
Score: 6/10 | Pathways: cGAS-STING, mito-ROS-NF-kB, treatment-target

Demonstrates mitochondrial DNA damage triggering cGAS-STING innate immune activation via mitochondrial dysfunction and ETC impairment, directly paralleling the BLUE/Loop A mechanism in the SAMHD1 syndrome, though in a drug-cardiotoxicity rather than SAMHD1 context.
DOI: 10.1126/sciadv.aeb2695

The mitochondrial logic of inflammaging: how energy imbalance drives fibroblast SASP and tissue-specific aging (from Geroscience/periodontology)
Yu Huan; Qiqi Wang; Rongkaixuan Fang; Yue Sun; Meiya Suo — Frontiers in Immunology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, NF-kB-IKK, mito-ROS-NF-kB, treatment-target

This paper reviews mitochondrial danger signal (mtROS/mtDNA)-driven cGAS-STING/NLRP3/NF-kB convergence in cellular senescence, mechanistically paralleling the SAMHD1 syndrome's Loop A/B and NF-kB crosstalk axes though in a general aging/periodontal context without SAMHD1 involvement.
DOI: 10.3389/fimmu.2026.1881243

How Redox Modulation May Help Prevent Age-Related Decline (from nutrition/geroscience)
M. Amirova — PHYTONutrients 2026
Score: 6/10 | Pathways: NLRP3, cGAS-STING, NF-kB-IKK, NF-kB-NLRP3-priming, mito-ROS-NF-kB, treatment-target

General review of mitochondrial DAMP-driven cGAS-STING/NLRP3/NF-kB inflammaging and NRF2 antioxidant modulation overlaps mechanistically with the IFN-mitochondrial-inflammasome axis but lacks SAMHD1-specific or dNTP pathway data.
DOI: 10.62368/pn.v5i1.71

Biallelic mutations in SUPV3L1 cause a variable leukodystrophy due to impaired mitochondrial degradosome function (from Neurology/leukodystrophy genetics)
L. Green; Noémie Hamilton; M. Elpidorou; R. Maroofian; Maha S. Zaki — Research Square 2026
Score: 6/10 | Pathways: cGAS-STING, AGS-spectrum, clinical-phenotype

Mitochondrial dsRNA degradosome dysfunction driving type I interferon activation via microglia parallels the SAMHD1-driven mitochondrial-to-interferon signaling axis, though it operates through a distinct RNA-sensing (rather than dNTPase/cGAS-mtDNA) mechanism within the broader interferonopathy spectrum.
DOI: 10.21203/rs.3.rs-4356120/v2

A Multi-Center Integrative Cohort Characterizing the Genetic, Clinical, and Transcriptomic Features of ACP5 Deficiency. (from Rheumatology/genetics (skeletal dysplasia and immune dysregulation))
Zhong Shiling; Ma Shuangyue; El Chazli Yasmine; Zheng Jika; Sun Xiangwei — Arthritis & rheumatology (Hoboken, N.J.) 2026
Score: 5/10 | Pathways: JAK-STAT, NF-kB-IKK, AGS-spectrum, clinical-phenotype, treatment-target

ACP5/SPENCDI is a distinct interferonopathy with overlapping type I IFN, NF-κB, and JAK-STAT signaling and JAK inhibitor treatment response, offering mechanistic and therapeutic parallels to the SAMHD1 interferonopathy spectrum despite being a different causal gene.
DOI: 10.1002/art.70279

Leveraging Mitochondria-Endoplasmic Reticulum Functional Interplay With an On-Demand Nanoparticle to Boost mtDNA-Based STING Immunotherapy. (from Oncology/nanomedicine)
Chen Han; Qu Haijing; Pan Yuqing; Cheng Wei; Wu Jie — Advanced materials (Deerfield Beach, Fla.) 2026
Score: 5/10 | Pathways: cGAS-STING, treatment-target

This paper explores mtDNA-driven cGAS-STING activation via a mitochondria-ER nanoparticle system for cancer immunotherapy, which is mechanistically relevant to the BLUE pathway's mtDNA-cGAS-STING axis but oncology-focused rather than SAMHD1-related.
DOI: 10.1002/adma.74146

CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates a β-thalassemia model. (from Hematology/gene therapy engineering)
Marone Romina; Lepore Rosalba; Paschoudi Kiriaki; Zuin Jessica; Sinopoli Alessan — bioRxiv : the preprint server for biology 2026
Score: 5/10 | Pathways: prime-editing, gene-therapy-delivery

Uses prime editing to engineer epitope-shielded CD34+ HSPCs for toxin-free conditioning, representing a relevant myeloid/HSC gene correction delivery advance analogous to strategies that could correct SAMHD1 missense variants, though disease context (beta-thalassemia) is unrelated to interferonopathy pathways.
DOI: 10.64898/2026.07.07.736903

Base Editing Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of X-Linked Severe Combined Immunodeficiency (from Gene therapy/immunodeficiency)
S. de Ravin; Michelle Ma; Yuzhi Yin; Siyuan Liu; Andrés Zea Vera — Journal of Human Immunity 2026
Score: 5/10 | Pathways: gene-therapy-delivery

Demonstrates base-editing correction of a het/hemizygous immune gene mutation (IL2RG) in HSPCs, relevant as a translational precedent for future SAMHD1 A565T correction strategies but not mechanistically tied to the interferon-mitochondrial-NLRP3 axis.
DOI: 10.70962/pidtc2026abstract.4

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

Annual gout flare frequency as a marker of sustained cardiovascular risk: a clinical threshold for risk stratification. (from Rheumatology/Cardiology)
Tung Kuei-Ting; Chen Solomon Chih-Cheng; Lee Chun — Rheumatology (Oxford, England) 2026
Score: 4/10 | Pathways: urate-NLRP3, clinical-phenotype

This clinical epidemiology paper links gout flare frequency to cardiovascular risk via cumulative inflammatory burden, tangentially relevant to the GOLD pathway (dGTP-uric acid-MSU crystal-NLRP3 axis) but does not address SAMHD1, interferon, or mitochondrial mechanisms directly.
DOI: 10.1093/rheumatology/keag370

Approach to the patient with APS-1/APECED. (from Endocrinology)
Webb Taura; Pechacek Joseph; Lionakis Michail S — The Journal of clinical endocrinology and metabolism 2026
Score: 4/10 | Pathways: JAK-STAT, clinical-phenotype, other

APS-1/AIRE is a distinct monogenic autoimmune tolerance disorder with IFN-gamma-driven pathology and JAK inhibitor treatment rationale, offering only loose conceptual parallel (JAKi as interferonopathy therapy) but no direct SAMHD1/cGAS-STING/NLRP3 mechanistic overlap.
DOI: 10.1210/clinem/dgag282

MDA5 and the integrated stress response control sex-specific type 1 diabetes onset in NOD mice. (from Endocrinology/diabetes autoimmunity)
Van Dis Erik; DeGidio Alessandra T; Yao Lara; Winship Damion; Sidrauski Carmela — bioRxiv : the preprint server for biology 2026
Score: 4/10 | Pathways: AGS-spectrum, other

This paper links MDA5/IFIH1 and integrated stress response to autoimmune diabetes in the AGS-adjacent RNA-sensing innate immune context, offering tangential mechanistic overlap (nucleic acid sensing driving type I IFN-like pathology) but no direct SAMHD1, cGAS-STING, NLRP3, or mitochondrial dNTP connection.
DOI: 10.64898/2026.07.02.736190

Compound delivery of eVLPs enhances prime editing for targeted genome engineering and high-throughput screening. (from functional genomics/gene editing technology)
Langley Jethro; Baudrier Lou; Curry Jada; Narta Kiran; Todesco Hayley M — Cell genomics 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

General-purpose eVLP/prime-editing methods advance is technically relevant to future SAMHD1 correction strategies but not targeted to immune/myeloid cells or the disease mechanism itself.
DOI: 10.1016/j.xgen.2026.101302

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7. (from neurology/gene therapy (Alzheimer's disease))
Kim Yunkyung; Lee Gaeun; An Saemin; Park Hanseul; Kim Hongwon — Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

This paper demonstrates PE7 prime editing technology for allele-specific correction (APOE4→APOE3) in neurons, offering a technical precedent for correcting heterozygous missense variants like SAMHD1 A565T, but is otherwise unrelated to interferonopathy/SAMHD1 biology or immune cell targeting.
DOI: 10.1002/advs.76658

SARS-CoV-2 ORF9b exploits mitochondrial recruitment to TOMM70 for proteasomal protection and tunes inflammatory remodeling during lung infection (from Virology/Structural Biology)
Yining Zhao; Lauriane Kergoat; Guilherme Dias de Melo; F. Larrous; Guillaume Dru — bioRxiv 2026
Score: 4/10 | Pathways: cGAS-STING, other

This paper explores SARS-CoV-2 ORF9b-mitochondrial (TOMM70) interactions and inflammatory remodeling via a Complex IV subunit substitute, touching on mitochondrial-innate immune crosstalk and interferon regulation but without direct SAMHD1, cGAS-STING, or NLRP3 pathway involvement relevant to the described syndrome.
DOI: 10.64898/2026.07.13.738231

Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives (from biomedical engineering/nanomedicine)
Meijia Yang; Yiqiong Song; Ziyang Wang; Ke Chao; Lifeng Li — MedComm 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

General review of genome editing delivery platforms with no SAMHD1-specific or immune/myeloid cell targeting focus, only tangentially relevant as background for future gene correction strategies.
DOI: 10.1002/mco2.70791

Proteomics-based characterization of apigenin-mediated anti-inflammatory effects in TNF-α-stimulated ARPE-19 cells. (from Ophthalmology/pharmacology (flavonoid anti-inflammatory research in retinal disease))
Chen Xi; Liao Meilin; Han Ruifang; Gao Juan; Lu Ping — International immunopharmacology 2026
Score: 3/10 | Pathways: NF-kB-IKK, JAK-STAT, ISG15-mitophagy

This paper studies apigenin's suppression of NF-κB/MAPK signaling and interferon-stimulated proteins (STAT1, ISG15, OAS3, IFIT3) in retinal pigment epithelial cells, touching peripheral pathway nodes (NF-κB, ISG15, IFN-related proteins) relevant to the syndrome's mechanism but with no SAMHD1, mitochondrial, or NLRP3 connection and an unrelated ophthalmologic/pharmacologic context.
DOI: 10.1016/j.intimp.2026.117048

Guiqi Baizhu prescription attenuates 5-FU-induced intestinal mucositis by targeting IKKβ to inhibit M1 macrophage polarization. (from Gastroenterology/Traditional Chinese Medicine oncology supportive care)
Zhou Yu-Cen; Li Ya-Ling; Ma Jing; Li Junjie; Si Qi — Chinese medicine 2026
Score: 3/10 | Pathways: NF-kB-IKK

Paper focuses on IKKβ/NF-κB inhibition in a traditional Chinese medicine model of chemotherapy-induced gut mucositis, only tangentially touching the NF-κB-IKK axis without connection to SAMHD1, interferonopathy, or mitochondrial mechanisms.
DOI: 10.1186/s13020-026-01406-z

Nanoengineering Systems for Gene Therapy: Mechanisms, Modalities, and Future Directions. (from nanotechnology/bioengineering)
Mais Raheem; Kumar Ayush; Ahmetaj Armand; Burgos-Crespo Gaby; Sanchez Mary Marga — International journal of molecular sciences 2026
Score: 3/10 | Pathways: gene-therapy-delivery, prime-editing

General review of nanomaterial delivery platforms for CRISPR/base/prime editing with no SAMHD1, immune cell, or mitochondrial-interferon pathway specificity.
DOI: 10.3390/ijms27135988

Intelligent metal-integrated hydrogels orchestrate pyroptosis and cGAS-STING for potentiated treatment of colorectal cancer peritoneal metastasis. (from Oncology/biomaterials drug delivery)
Zhang Lin-Zhu; Si Liang-Wei; Xu Hui; Xiong Fei; Qin Juan — 2026
Score: 3/10 | Pathways: cGAS-STING, other

Describes cGAS-STING activation via mtDNA/pyroptosis in a cancer-therapeutic (hydrogel/cobalt) context unrelated to SAMHD1 mechanism or family phenotypes, though it touches the same signaling node.
DOI: 10.1016/j.jconrel.2026.115184

Orchestrating the gut microbiota–mitochondrial–immune axis in gynecological diseases: mechanisms and dual-targeting therapeutic strategies (from Gynecology/Reproductive Health)
Haixia Tang; Yiting Zhang; Yanting Wang; Ze Zhou; Rong Sun — Frontiers in Reproductive Health 2026
Score: 3/10 | Pathways: cGAS-STING, NLRP3, other

This review covers gut microbiota-mitochondria-immune crosstalk (cGAS-STING/NLRP3, mtDNA, mitophagy) in gynecological disease but is not connected to SAMHD1, dNTP metabolism, or the family phenotype spectrum.
DOI: 10.3389/frph.2026.1845581

Pathway Coverage This Week

  • treatment-target: 20 papers
  • cGAS-STING: 18 papers
  • NLRP3: 11 papers
  • NF-kB-IKK: 11 papers
  • other: 6 papers
  • clinical-phenotype: 6 papers
  • gene-therapy-delivery: 6 papers
  • mito-ROS-NF-kB: 5 papers
  • prime-editing: 5 papers
  • urate-NLRP3: 3 papers
  • AGS-spectrum: 3 papers
  • JAK-STAT: 3 papers
  • nucleotide-rewiring: 2 papers
  • VDAC1: 2 papers
  • NF-kB-NLRP3-priming: 2 papers
  • mTOR-lysosomal: 2 papers
  • ISG15-mitophagy: 2 papers
  • dNTPase: 1 papers
  • mito-dNTP-transport: 1 papers
  • mito-dNTp-transport: 1 papers
  • POLG-mtDNA: 1 papers
  • IRF7-metabolic: 1 papers

SAMHD1 Research Digest — 2026-07-13

Generated by samhd1_monitor | Model: claude-sonnet-5

Summary: 6 papers evaluated | 1 high-relevance (≥7) | 4 medium (5–6) | 1 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Auto-added to Zotero (threshold ≥6)

Mitochondrial DNA and Mitochondrial-Derived Vesicles as Immunometabolic Modulators of Innate Immunosurveillance through Control of the Mitochondrial Permeability Transition Pore (from Mitochondrial cell biology / immunometabolism)
Patrycja Anna Glogowski; S. Nesci; Antonia Cugliari; F. Trombetti; M. Fabbri — Translational Insights 2026
Score: 8/10 | Pathways: cGAS-STING, NLRP3, VDAC1, NF-kB-IKK, POLG-mtDNA, treatment-target

This paper details the mPTP-mtDNA-NLRP3/cGAS-STING axis and mitochondrial quality control (mitophagy/MDVs) that directly parallels the BLUE/PURPLE mechanism loops (VDAC1-mediated mtDNA escape, ox-mtDNA, NLRP3 activation) central to the SAMHD1 A565T pathophysiology, though it does not mention SAMHD1 itself.
DOI: 10.53941/ti.2026.100010

🟡 Medium Relevance (Score 5–6)

Score ≥6 auto-added to Zotero; lower scores: review manually

METTL5-mediated rRNA modification controls prostate cancer progression through the IRF7/DNA2 axis and mitophagy regulation. (from Oncology (prostate cancer molecular biology))
Yang Ruifeng; Ge Qintao; Wu Fengyao; Long Manmei; Li Bingyu — Oncogene 2026
Score: 6/10 | Pathways: IRF7-metabolic, POLG-mtDNA, BIK-cancer, clinical-phenotype

This paper links IRF7 (a core interferon pathway transcription factor also relevant to SAMHD1 biology) to mitochondrial DNA maintenance (via DNA2) and mitophagy in prostate cancer, a phenotype tracked in the SAMHD1 family, though the mechanism (rRNA m6A/METTL5) is distinct from SAMHD1 dNTPase pathways.
DOI: 10.1038/s41388-026-03867-w

Design and Synthesis of Novel Isoflavene TANK-Binding Kinase 1 Inhibitors With Anti-Inflammatory Activity. (from medicinal chemistry/drug design)
Falasca Valerio; Jayasekara W Samantha N; Nardo Dominic De; Wenholz Daniel S; Ga — ChemMedChem 2026
Score: 6/10 | Pathways: NF-kB-IKK, treatment-target

TBK1 inhibitors targeting NF-κB and type I IFN signaling are directly relevant to the IKKε/TBK1 non-canonical NF-κB and IRF3/IFN-I axis described in the disease mechanism, offering a potential therapeutic strategy for the interferonopathy component.
DOI: 10.1002/cmdc.70376

Successful salvage treatment with baricitinib for macrophage activation syndrome complicating adult-onset Still's disease during interleukin-6 inhibition: a case report and literature review. (from Rheumatology)
Nishisaka Kazuma; Ueda Yo; Shirasugi Iku; Yamada Hirotaka; Okano Takaichi — Modern rheumatology case reports 2026
Score: 5/10 | Pathways: JAK-STAT, treatment-target, clinical-phenotype

Baricitinib (JAK1/2 inhibitor) treating hyperinflammatory macrophage activation syndrome via IL-6/IFN-gamma/GM-CSF overlaps with the IFN-I/JAK-STAT axis and NLRP3-driven hyperinflammation central to the SAMHD1 model, with direct treatment-target relevance despite lacking SAMHD1 linkage.
DOI: 10.1093/mrcr/rxag072

CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates a β-thalassemia model (from Hematology/gene therapy engineering)
Romina Marone; Rosalba Lepore; K. Paschoudi; Jessica Zuin; A. Sinopoli — bioRxiv 2026
Score: 5/10 | Pathways: prime-editing, gene-therapy-delivery

Uses prime editing on CD34+ HSPCs to engineer epitope resistance for toxin-free conditioning, relevant as a myeloid/HSC gene-editing delivery advance analogous to future correction strategies for a het missense variant like SAMHD1 A565T, though not disease-specific.
DOI: 10.64898/2026.07.07.736903

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

Organ-resolved endothelial regulatory programs link aging and metabolic overload to vascular immune remodeling (from Vascular biology/aging endothelial genomics)
Masataka Yokoyama; A. Nakayama; Yuki Taki; Mingyang Chen; Yingbo Gong — bioRxiv 2026
Score: 4/10 | Pathways: JAK-STAT, IRF7-metabolic, other

This paper describes an IRF/STAT-centered type I IFN endothelial aging program and metabolic vascular remodeling, tangentially echoing IFN-I/JAK-STAT themes but without SAMHD1, NLRP3, cGAS-STING, or mitochondrial dNTP mechanisms central to the disease profile.
DOI: 10.64898/2026.07.02.736039

Pathway Coverage This Week

  • treatment-target: 3 papers
  • NF-kB-IKK: 2 papers
  • POLG-mtDNA: 2 papers
  • IRF7-metabolic: 2 papers
  • clinical-phenotype: 2 papers
  • JAK-STAT: 2 papers
  • cGAS-STING: 1 papers
  • NLRP3: 1 papers
  • VDAC1: 1 papers
  • BIK-cancer: 1 papers
  • prime-editing: 1 papers
  • gene-therapy-delivery: 1 papers
  • other: 1 papers

SAMHD1 Research Digest — 2026-07-12

Generated by samhd1_monitor | Model: claude-sonnet-5

Summary: 9 papers evaluated | 0 high-relevance (≥7) | 6 medium (5–6) | 3 low (3–4) | 0 scored <3

🟡 Medium Relevance (Score 5–6)

Score ≥6 auto-added to Zotero; lower scores: review manually

Abscisic acid ameliorates inflammation-related diseases by inhibiting NLRP3 inflammasome activation. (from pharmacology/natural product chemistry)
Jiao Chenyang; Jia Lulu; Liu Qian; Zhang Weihang; Zhang Wei — International immunopharmacology 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, mTOR-lysosomal, treatment-target

This paper identifies a novel NLRP3 inhibitor (ABA/PDZD8-lysosomal axis) validated in MSU-induced gouty arthritis, directly relevant to the GOLD stream (dGTP→uric acid→MSU crystals→NLRP3) and offers a potential therapeutic strategy for NLRP3 hyperactivation in the syndrome.
DOI: 10.1016/j.intimp.2026.117119

ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype. (from Dermatology/Rheumatology (psoriasis, psoriatic arthritis))
Assan Florence; Tragin Margot; Marella Sahiti; Lipecka Joanna; Roger Kévin — The Journal of experimental medicine 2026
Score: 6/10 | Pathways: JAK-STAT, treatment-target, clinical-phenotype, AGS-spectrum

Monogenic ADAR1 loss-of-function causing constitutive type I IFN signature and inflammatory disease (psoriasis) mirrors the interferonopathy mechanism central to SAMHD1 A565T pathology, and JAK inhibitor (upadacitinib) responsiveness directly parallels proposed treatment strategies for the family syndrome.
DOI: 10.1084/jem.20260054

A micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by attenuating cGAS-STING-type I IFN signaling in macrophages. (from Oncology/tumor immunology)
Wang Xingwen; Zhang Yi; Ma Jiangwen; Lin Qingyu; Wang Zhenghang — Nature cancer 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

This paper details a novel negative-feedback mechanism (UEIS-TBK1 condensates) directly within the cGAS-STING-TBK1-type I IFN axis in macrophages, a core pathway implicated in the SAMHD1 interferonopathy syndrome, though its focus on tumor immunology rather than SAMHD1/mitochondrial dysfunction limits direct relevance.
DOI: 10.1038/s43018-026-01195-2

STING-associated metabolic changes engage AMPK to amplify interferon signaling in Listeria-infected macrophages. (from Microbiology/infectious disease immunometabolism)
Chen Shukun; Wang Xiao; Duan Zhuoyu; Wang Min; Qu Xiaoya — Biochimica et biophysica acta. Molecular cell research 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, other

Demonstrates STING-driven metabolic reprogramming (glycolysis/AMPK/TBK1) amplifying type I IFN signaling, directly relevant to the STING/IFN-I axis (Loop A) though in a bacterial infection context rather than SAMHD1-driven cGAS-STING activation.
DOI: 10.1016/j.bbamcr.2026.120172

ISG15 At the Crossroads of Innate Immunity and Host Survival in Response to Typhoid Toxin. (from microbiology/infectious disease (Salmonella typhoid toxin biology))
Valenzuela Camila; Enninga Jost — Molecular microbiology 2026
Score: 6/10 | Pathways: cGAS-STING, ISG15-mitophagy, treatment-target

Describes a STING-TBK1-dependent, ISGylation-independent free ISG15 pathway triggered by cytosolic DNA sensing that promotes cell survival, mechanistically parallel to the BLUE/RED axes in the SAMHD1 syndrome even though the trigger is bacterial genotoxin rather than mtDNA leakage.
DOI: 10.1111/mmi.70075

Recent Insights into Mitochondrial Dysfunction-Driven Cellular Senescence in Chronic Kidney Disease (from Nephrology)
Ziyi Guo; Zhenkai Wang; Zixuan Song; Tian Wang; Jingai Fang — BIOCELL 2026
Score: 5/10 | Pathways: NLRP3, cGAS-STING, POLG-mtDNA, treatment-target

Discusses mitochondrial dysfunction driving cGAS-STING/NLRP3-mediated senescence and SASP, mechanistically overlapping with the interferon-mitochondrial pathways in the SAMHD1 syndrome but in a CKD context without any SAMHD1 or direct genetic linkage.
DOI: 10.32604/biocell.2026.083188

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

Mitoxyperilysis related signature predicts prognosis innate immune remodeling and myeloid enriched tumor microenvironment states in breast cancer (from oncology)
Li Zhen; Yang Menglei; Li Yongfei — preprint (preprint) 2026
Score: 4/10 | Pathways: NLRP3, cGAS-STING, other

This breast cancer bioinformatics paper touches NLRP3/cGAS-STING and mitochondrial lytic cell death but is oncology-context focused on tumor prognosis signatures rather than SAMHD1 mechanism or family phenotype relevance.
DOI: 10.21203/rs.3.rs-9963383/v1

p38 MAP kinase senses short-chain fatty acids to attenuate Toll-like receptor signaling and intestinal inflammation. (from Gastroenterology/microbiome metabolism)
Wu Qingang; Shi Rongkai; Xiao Liwei; He Xuxiao; Chen Zhuoneng — Science advances 2026
Score: 3/10 | Pathways: cGAS-STING, NF-kB-IKK, other

This paper describes SCFA-mediated suppression of TLR/TBK1-IRF3 signaling in intestinal inflammation, sharing the TBK1-IRF3 node with the BLUE loop but is otherwise unrelated to SAMHD1 or the core interferon-mitochondrial mechanism.
DOI: 10.1126/sciadv.aef1419

TANK potentiates antiviral innate immunity by recruiting deubiquitinase USP46 to activate IKKε. (from Fish virology/comparative immunology)
Li Zhenghao; Yang Can; Shu Juanjuan; Wang Jiaxin; Wang Xinyu — PLoS pathogens 2026
Score: 3/10 | Pathways: NF-kB-IKK

This paper describes IKKε regulation by TANK/USP46 in fish antiviral immunity, a tangential non-mammalian model with only distant relevance to the IKKε/IRF3/NF-kB axis implicated in the SAMHD1 syndrome.
DOI: 10.1371/journal.ppat.1014412

Pathway Coverage This Week

  • treatment-target: 6 papers
  • cGAS-STING: 6 papers
  • NLRP3: 3 papers
  • other: 3 papers
  • NF-kB-IKK: 2 papers
  • urate-NLRP3: 1 papers
  • mTOR-lysosomal: 1 papers
  • JAK-STAT: 1 papers
  • clinical-phenotype: 1 papers
  • AGS-spectrum: 1 papers
  • ISG15-mitophagy: 1 papers
  • POLG-mtDNA: 1 papers

SAMHD1 Research Digest — 2026-07-08

Generated by samhd1_monitor | Model: claude-sonnet-5

Summary: 88 papers evaluated | 12 high-relevance (≥7) | 33 medium (5–6) | 43 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Auto-added to Zotero (threshold ≥6)

Upregulation of macrophage UPP1 promotes lung adenocarcinoma metastasis through an mtROS-cGAS-NLRP3 inflammasome axis. (from Oncology (tumor immunology/lung adenocarcinoma))
Feng MingTao; Gao Chao; Yang YueChao; Li Deheng; Zhou Changshuai — Cell death discovery 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, mito-ROS-NF-kB, nucleotide-rewiring, treatment-target

Demonstrates a mechanistically analogous nucleotide-dysregulation → mtROS → mtDNA leakage → cGAS-STING → NLRP3 → IL-1β axis in macrophages driving tumor progression, closely paralleling the PURPLE/BLUE/GOLD SAMHD1 pathways though in an oncology (lung adenocarcinoma) rather than SAMHD1 context.
DOI: 10.1038/s41420-026-03226-4

Melatonin alleviates rheumatoid arthritis via elimination of damaged mitochondria. (from Rheumatology)
Wang Bo; Wu Yanglin; Li Gen; Che Zhenjia; Sun Qi — Autophagy 2026
Score: 7/10 | Pathways: NLRP3, mito-ROS-NF-kB, clinical-phenotype, treatment-target

Demonstrates mitophagy-mediated clearance of damaged mitochondria/mtDNA suppresses NLRP3 inflammasome activation and cytokine release in RA models, directly paralleling the family's mitochondrial-NLRP3 mechanism and RA phenotype seen in the pedigree.
DOI: 10.1080/15548627.2026.2689419

Copper Exposure Promotes Mitochondrial VDAC Oligomerization and Releases mtDNA to Induce Pyroptosis in Pig Hepatocytes. (from Veterinary toxicology/agricultural food chemistry)
Qiu Wenyue; Chen Wei; Yang Shanglong; Xi Hao; Liao Jianzhao — Journal of agricultural and food chemistry 2026
Score: 7/10 | Pathways: VDAC1, NLRP3, treatment-target

Demonstrates the exact VDAC1 oligomerization → mtDNA release → NLRP3 pyroptosis axis (Loop B/BLUE-adjacent) using the same VBIT-4/MCC950 pharmacologic tools referenced in the SAMHD1 mechanism, though in a copper toxicity/veterinary model rather than SAMHD1 context.
DOI: 10.1021/acs.jafc.6c03617

STAT2 R148 variant: A 16th-century founder mutation and clinical response to high-dose JAK inhibitor therapy. (from Clinical genetics/pediatric neuroimmunology)
Parvaneh Nima; Molatefi Rasol; Gruber Conor; Biglari Sajjad; Moradi Leila — Journal of human immunity 2026
Score: 7/10 | Pathways: JAK-STAT, AGS-spectrum, treatment-target, clinical-phenotype

STAT2 R148 causes type I interferonopathy via disrupted USP18 negative feedback, directly parallel to the IFN-I overproduction in the SAMHD1 syndrome, and demonstrates JAK inhibitor (ruxolitinib) efficacy as a therapeutic strategy relevant to this family's management.
DOI: 10.70962/jhi.20260001

Design, Synthesis, and Pharmacological Evaluation of cGAS/HDAC Dual Inhibitors for Treatment of Autoimmune Diseases. (from Medicinal chemistry/drug discovery)
Zhou Zihua; Chen Mingjie; Lei Shuyue; Wang Meng; Ding Chunyong — Journal of medicinal chemistry 2026
Score: 7/10 | Pathways: cGAS-STING, AGS-spectrum, treatment-target

A novel small-molecule dual cGAS/HDAC inhibitor with demonstrated efficacy in a murine Aicardi-Goutières syndrome model directly targets the BLUE-loop cGAS-STING pathway central to this SAMHD1 interferonopathy and offers a plausible therapeutic candidate class.
DOI: 10.1021/acs.jmedchem.6c00583

TAX1BP1 targets STING1 via microautophagy and Golgiphagy to limit inflammatory signaling. (from cell biology/autophagy)
Suklabaidya Sujit; Mohanty Suchitra; Harhaj Edward W — Autophagy 2026
Score: 7/10 | Pathways: cGAS-STING, treatment-target

Describes a novel negative-feedback mechanism (TAX1BP1-mediated Golgiphagy/microautophagy) that degrades activated STING1, directly relevant to the BLUE pathway's IFN-I amplification and a potential therapeutic node for dampening chronic interferonopathy in SAMHD1 A565T carriers.
DOI: 10.1080/15548627.2026.2658230

Hydroxycinnamic acids target COPII cargo sorting machinery to attenuate inflammation via the cGAS-STING axis. (from Ethnopharmacology/hepatology-metabolic disease)
Ma Xiaojing; Wang Jiaming; Guo Yakun; Nan Yanan; Guo Linyue — Journal of ethnopharmacology 2026
Score: 7/10 | Pathways: cGAS-STING, treatment-target, NF-kB-IKK

Demonstrates a druggable choke point (COPII/Sec24-mediated STING trafficking) directly upstream of the cGAS-STING-TBK1-IRF3 axis central to the BLUE/RED interferon loops, with therapeutic implications for metabolic/inflammatory phenotypes relevant to this family's syndrome.
DOI: 10.1016/j.jep.2026.121881

Breaking a mitochondrial danger-STING feed-forward amplifier preserves alveolar-capillary architecture and dampens interferon-chemokine signaling in acute lung injury. (from pulmonology/critical care)
Elmorsy Elsayed A; Amer Maha M; Hamad Rabab S; Abdel-Hamed Mohamed R; Farrag Als — Tissue & cell 2026
Score: 7/10 | Pathways: cGAS-STING, treatment-target, mito-ROS-NF-kB, NF-kB-IKK

Demonstrates a mitochondrial danger signal-cGAS/STING-IFN feed-forward loop driving tissue injury and its pharmacological interruption, directly paralleling the BLUE/RED loop mechanism and STING-targeted therapeutics relevant to the SAMHD1 interferonopathy model, though in an acute lung injury rather than SAMHD1 context.
DOI: 10.1016/j.tice.2026.103514

CMPK2 promotes M1 macrophage polarization in sepsis-induced acute lung injury via NLRP3/NF-κB signalling. (from Critical care/pulmonology (sepsis-induced acute lung injury))
Li Cheng; Ding Peng; Zheng Zenglu; Wei Huawei; Yang Yutong — International immunopharmacology 2026
Score: 7/10 | Pathways: NLRP3, NF-kB-IKK, mito-dNTP-transport, nucleotide-rewiring

CMPK2, a key player in the CMPK2-vs-PNC1/2 mitochondrial dNTP supply axis directly implicated in the SAMHD1 mechanism, is shown here to drive NLRP3/NF-κB-mediated macrophage inflammation and mitochondrial ultrastructural damage in sepsis, providing mechanistic support for the CMPK2-mitochondrial-inflammasome link even though SAMHD1 itself is not studied.
DOI: 10.1016/j.intimp.2026.116906

Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process. (from Evolutionary biology / gerontology)
Salminen Antero; Kaarniranta Kai; Kauppinen Anu — 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, AGS-spectrum, other

This review directly supports the BLUE loop mechanism (mtDNA/dsRNA leakage activating cGAS-STING and related sensors driving IFN-I and inflammaging) central to the SAMHD1 A565T pathophysiology, though it addresses general aging rather than SAMHD1 specifically.
DOI: 10.1007/s10522-026-10470-9

Specific bile acids can elicit the type-I interferon response through the cGAS-STING pathway. (from Hepatology/bile acid metabolism)
He Jianan; Huang Ziyan; Xiong Caiwan; Huang Zhicheng; Yan Hao — 2026
Score: 7/10 | Pathways: cGAS-STING, VDAC1, treatment-target

Demonstrates bile acid-induced mtDNA release via Bax/Bak pores activating cGAS-STING/IFN-I, directly paralleling the BLUE pathway mechanism (VDAC1/mtDNA-cGAS-STING) and connecting to the family's hepatology phenotypes (cholecystectomy clustering, bile acid-innate immunity axis).
DOI: 10.1186/s12964-026-03036-2

Senataxin loss induces cGAS–STING-mediated mitochondrial dysfunction (from Neurology/neurodegeneration (ataxia-AOA2))
Fishburn Judith L.A.; Zhao Hongchang; Fosselman Will; Flores Julian; Wong Megan — preprint (preprint) 2026
Score: 7/10 | Pathways: cGAS-STING, AGS-spectrum, POLG-mtDNA, clinical-phenotype

Demonstrates cGAS-STING-driven mitochondrial dysfunction (ROS, hyperfusion, reduced function) from a distinct genomic instability trigger, directly paralleling the BLUE loop mechanism proposed for SAMHD1 haploinsufficiency and reinforcing the interferon-mitochondrial convergence model.
DOI: 10.64898/2026.06.26.734838

🟡 Medium Relevance (Score 5–6)

Score ≥6 auto-added to Zotero; lower scores: review manually

Targeting IMPDH to inhibit SAMHD1 in KMT2A-rearranged leukaemia. (from Oncology/hematology)
Klootsema Yolande; Tsesmetzis Nikolaos; Sharma Sushma; Hofmann Sophia; Thier Jon — Cell cycle (Georgetown, Tex.) 2026
Score: 6/10 | Pathways: dNTPase, treatment-target

This paper directly studies SAMHD1's dNTPase activity and GTP/dGTP allosteric regulation in the context of leukemia chemotherapy resistance, providing mechanistic insight into SAMHD1 dNTP pool control relevant to the core disease mechanism, though not directly tied to A565T or the interferon-mitochondrial syndrome.
DOI: 10.1080/15384101.2025.2601796

Inhibition of toll-like receptor 4 by allicin suppresses mitochondrial DNA-mediated inflammation and pyroptosis to alleviate myocardial ischemia-reperfusion injury. (from Cardiology)
Liang Shichao; Wu Song; Yin Jiajie; Gao Tong; Liu Mengru — Phytomedicine : international journal of phytotherapy and phytopharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, NF-kB-IKK, mito-ROS-NF-kB, treatment-target

Demonstrates mtDNA leakage driving cGAS-STING and NLRP3-pyroptosis via TLR4 in cardiac ischemia-reperfusion, mechanistically parallel to the BLUE/PURPLE loops and NF-kB priming axis though in a cardiology context rather than SAMHD1-driven interferonopathy.
DOI: 10.1016/j.phymed.2026.158513

Asiatic acid mitigates PM2.5-elicited cardiomyocyte pyroptosis via suppression of mtDNA-driven cGAS-STING-NLRP3 signalling. (from Cardiology/environmental toxicology)
Chen Zefeng; Yu Xianguan; Tang Leile; Zhao Yunyue; Yang Xubin — Journal of cardiovascular pharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, treatment-target

Demonstrates mtDNA-driven cGAS-STING-NLRP3-pyroptosis cascade in cardiomyocytes and a natural compound that blocks it, directly mirroring the Loop A/B mechanism (VDAC1-independent mtDNA release, TFAM loss, cGAS-STING-NLRP3 axis) relevant to the family's cardiac and interferonopathy phenotype though not SAMHD1-specific.
DOI: 10.1097/FJC.0000000000001858

Dendrobine alleviates lung injury in septic mice by inhibiting mitochondrial-endoplasmic reticulum crosstalk-mediated NLRP3 inflammasome activation. (from critical care/sepsis pharmacology)
Zhang Shichao; Luo Kaihang; Wei Xinyue; Qing Cheng; Zhang Jianguo — Journal of pharmacological sciences 2026
Score: 6/10 | Pathways: VDAC1, NLRP3, treatment-target

Demonstrates VDAC1-centered mitochondrial-ROS/mtDNA release driving NLRP3 activation in macrophages, mechanistically parallel to the BLUE/GOLD loops though via IP3R-GRP75-VDAC1-HK2 glycolytic axis rather than SAMHD1/dGTP.
DOI: 10.1016/j.jphs.2026.05.007

A nucleic acid regulation strategy under mechanical stress for intervertebral disc degeneration treatment. (from Orthopedics/spine surgery (intervertebral disc degeneration))
Wang Wenchao; Huo Wenxiang; Qian Dingfei; Hou Peihong; Su Cheng — Bioactive materials 2026
Score: 6/10 | Pathways: NLRP3, treatment-target, mito-ROS-NF-kB

Describes a mtDNA leakage-cfDNA-NLRP3 inflammasome axis with MCC950 (a named NLRP3 inhibitor in the syndrome's mechanism) as therapeutic, offering a mechanistic and pharmacologic parallel to Loop B/NLRP3 activation despite different disease context.
DOI: 10.1016/j.bioactmat.2026.05.027

Silibinin restricts mitochondria-associated inflammatory pathways in LPS-stimulated murine microglia BV2 through TREM2. (from Neuroinflammation/pharmacology)
Chen Wenhui; Wang Xiaoling; Liu Panwen; Kang Yu; Hayashi Toshihiko — Cellular immunology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, mito-ROS-NF-kB, treatment-target

This paper demonstrates a natural compound restoring mitochondrial quality control to suppress STING and NLRP3 inflammasome activation in microglia, directly relevant to the core mitochondrial-inflammatory pathways implicated in the syndrome, though not SAMHD1-specific.
DOI: 10.1016/j.cellimm.2026.105102

Cellular copper overload mediates senescence-associated secretory phenotype induction in BV2 microglia following lead and copper exposure. (from Toxicology/Neurodegeneration)
Wang Tao; Chen Chao; Li Ran; Su Li-Hong; Tian Hao-Jie — Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, mito-ROS-NF-kB

Demonstrates mtDNA release triggering cGAS-STING-NLRP3 axis via ROS in microglia, mechanistically paralleling the VDAC1/cGAS-STING-NLRP3 (Loop A/B) pathways central to this disease model, though driven by heavy metal toxicity rather than SAMHD1 dysfunction.
DOI: 10.1016/j.fct.2026.116068

cGAS-STING axis: A central regulator of neural homeostasis and neuroinflammatory pathogenesis. (from Neurology)
Zhang Jiajie; Li Jiarui; Li Yanan; Liu Chunxiao; Shi Lei — Neural regeneration research 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, AGS-spectrum

Reviews cGAS-STING/IFN-I-driven neuroinflammation and its therapeutic targeting (including ataxia-telangiectasia, an interferonopathy-adjacent condition), directly relevant to Loop A and the AuDHD/neuro-immune features of the family but not SAMHD1-specific.
DOI: 10.4103/NRR.NRR-D-25-00367

Monosodium urate crystals induce lytic macrophage death partially dependent on both pyroptosis and necroptosis. (from Rheumatology (gout/crystal arthropathy))
Geng Zhijun; Wu Di; Hou Yajing; Kang Lulu; Zhang Xiaofeng — Clinical rheumatology 2026
Score: 6/10 | Pathways: urate-NLRP3, NLRP3

This paper details MSU crystal-induced macrophage lytic death and inflammasome dynamics, directly relevant to the GOLD stream's urate-NLRP3 axis and gout pathogenesis in the mechanism model, though it does not address SAMHD1 or dNTP metabolism.
DOI: 10.1007/s10067-026-08262-0

Nrf2 promotes NLRP3 inflammasome assembly and activation by Klf9-TXNIP axis. (from Rheumatology/immunometabolism)
Zhou You; You Hui; Xia Xin-Yu; Zhang Ke; Jiang Hui — Cell death discovery 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, NF-kB-NLRP3-priming, treatment-target

Describes a novel Nrf2-Klf9-TXNIP mechanism for NLRP3 inflammasome assembly and validates relevance in MSU-crystal gouty arthritis, directly relevant to the GOLD stream and urate-NLRP3 axis in the mechanism map, though not SAMHD1-specific.
DOI: 10.1038/s41420-026-03219-3

SIRT5 desuccinylates PRDX3 to promote its chaperone-mediated autophagy and mitigate mitochondrial dysfunction in MSU crystal-induced inflammation. (from Rheumatology/gout biochemistry)
Deng Yaxin; Yu Kailin; Ou Lijun; Wang Ling; Cai Yuanze — International immunopharmacology 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, mito-ROS-NF-kB, treatment-target

This paper details MSU crystal-induced mitochondrial dysfunction driving NLRP3 activation via PRDX3 accumulation, directly relevant to the GOLD stream (dGTP-purine catabolism-uric acid-MSU-NLRP3) in the disease model, though it does not involve SAMHD1 or interferon signaling.
DOI: 10.1016/j.intimp.2026.117064

SLC16A9-mediated uric acid uptake promotes myocardial hypertrophy in dilated cardiomyopathy via NLRP3 inflammasome activation. (from Cardiology)
Hu Zhi; Ding Yiming; Wang Tingzhong; Hou Xiaolin; Song Qiang — Experimental cell research 2026
Score: 6/10 | Pathways: urate-NLRP3, NLRP3, treatment-target

Demonstrates a urate-transporter-driven NLRP3 activation axis (GOLD stream analog) in cardiomyopathy, mechanistically relevant to the uric acid/MSU-NLRP3 route implicated in the SAMHD1 syndrome and to potential cardiac phenotype in carriers.
DOI: 10.1016/j.yexcr.2026.115085

Design, semi-synthesis and biological evaluation of grandiflorenic acid derivatives as potent covalent NLRP3 inhibitors. (from medicinal chemistry/pharmacology)
Pérez-Rodríguez Daniel; Amesty Ángel; Oramas-Royo Sandra; Fernández-Vega Eva; Cu — European journal of medicinal chemistry 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, treatment-target

Describes novel covalent small-molecule NLRP3 inhibitors effective across multiple activation stimuli (including MSU crystals), representing a potential therapeutic strategy directly relevant to the NLRP3 hyperactivation central to the SAMHD1 A565T interferon-mitochondrial syndrome.
DOI: 10.1016/j.ejmech.2026.118935

Baricitinib in Two Pediatric Patients with COPA syndrome: A Case Series and Literature Review. (from Pediatric rheumatology/pulmonology)
Villarreal Enrique G; Dissanayake Dilan; Laxer Ronald M; Yip Kenneth W; Kritzing — Modern rheumatology case reports 2026
Score: 6/10 | Pathways: JAK-STAT, treatment-target, AGS-spectrum, clinical-phenotype

COPA syndrome is a type I interferonopathy treated with baricitinib (JAK inhibitor), directly paralleling the IFN-I/JAK-STAT treatment strategy relevant to SAMHD1-driven interferonopathy in this family.
DOI: 10.1093/mrcr/rxag052

Loss of the kinases TBK1 and IKKε sensitizes target cancer cells to T cell killing through an IFN-γ-mediated inflammatory death program. (from cancer immunology/immuno-oncology)
Sun Nicholas D; Carr Allison R; Krogman Erica N; Chawla Yogesh; Zhong Jun — Science signaling 2026
Score: 6/10 | Pathways: NF-kB-IKK, JAK-STAT, treatment-target, other

Demonstrates TBK1/IKKε (non-canonical NF-kB/IFN kinases central to the disease's NF-κB-IKK crosstalk axis) as inhibitors of RIPK1-dependent inflammatory death and NF-κB activation, revealing a mechanistic link between IFN signaling, NF-κB, and cell death that is adjacent to the interferon-mitochondrial-NF-κB circuitry implicated in the SAMHD1 syndrome, though not SAMHD1-specific.
DOI: 10.1126/scisignal.adz7366

Targeting the cGAS-STING pathway alleviates neuroinflammation and cognitive impairment induced by chronic infection of Toxoplasma gondii. (from Neurology/Infectious Disease (parasitology-neuroinflammation))
Xing Yihui; Lv Huiling; He Peixuan; Xu Yongyao; Shen Weifan — Journal of neuroinflammation 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, clinical-phenotype

Demonstrates cGAS-STING pathway activation driving neuroinflammation, senescence/SASP, and cognitive impairment in a chronic infectious trigger model, mechanistically relevant to the IFN-I/BLUE loop and neurologic/AuDHD phenotype axis though not SAMHD1-specific.
DOI: 10.1186/s12974-026-03937-6

Tegument protein UL16 of herpes simplex virus 1 suppresses the innate immune response by downregulating MAVS abundance via mitophagy. (from virology/microbiology (HSV-1 immune evasion))
Wang Jingwen; Zhu Rongli; Yi Ping; Gan Mengyao; Long Feng — Autophagy 2026
Score: 6/10 | Pathways: cGAS-STING, ISG15-mitophagy, other

This paper shows a viral tegument protein degrading MAVS via FUNDC1-mediated mitophagy to suppress RLR/IFN-I signaling, providing mechanistic insight into virus-induced mitophagy-immune crosstalk that parallels the mitophagy-block/interferon axis relevant to SAMHD1-driven interferonopathy and post-viral ME/CFS triggers.
DOI: 10.1080/15548627.2026.2698747

GAMG alleviates silicosis inflammation and fibrosis by targeting STING. (from Pulmonology/occupational medicine (silicosis))
Zhang Jing; Xang Miaoqing; Yao Zongze; Shao Wei; Liu Zhiyu — Ecotoxicology and environmental safety 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target

This paper demonstrates STING/TBK1/NF-κB pathway activation via cytosolic dsDNA driving inflammation and fibrosis, directly relevant to the BLUE loop (cGAS-STING-IRF3-IFN-I) and NF-κB crosstalk mechanisms central to the SAMHD1 syndrome, and identifies a small-molecule STING inhibitor (GAMG) with therapeutic implications.
DOI: 10.1016/j.ecoenv.2026.120405

Dexamethasone activates anti-tumor immunity in multiple myeloma by dismantling the GR-PPP1CB complex to restore STING/IRF3 signaling. (from Oncology (multiple myeloma immunotherapy))
Wang Chen; Liu Lingling; Zhang Jiale; Sun Shanliang; Lv Xinyu — Journal for immunotherapy of cancer 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, other

This paper details TBK1-IRF3/STING pathway modulation via GR-PPP1CB in multiple myeloma, directly intersecting with the core interferon-STING axis (Loop A) relevant to SAMHD1 mechanism and the family's multiple myeloma phenotype, though not SAMHD1-specific.
DOI: 10.1136/jitc-2026-015256

BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells. (from Gynecologic oncology (BRCA1/fallopian tube epithelium))
Madaan Vidushi; Kollara Alexandra; Spaner David; Brown Theodore J — Neoplasia (New York, N.Y.) 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK, JAK-STAT, treatment-target

Demonstrates cGAS-STING-TBK1-IRF3 driven type-I interferon signaling (ISG15/USP18) with NF-kB permissive crosstalk in a DNA-damage/genome-instability context, mechanistically analogous to the SAMHD1-driven IFN-I/NF-kB axis and relevant to oncology surveillance in carrier families.
DOI: 10.1016/j.neo.2026.101320

ANXA2 suppresses antiviral immunity by impeding STING Golgi translocation and disrupting the TBK1/IKKε-IRF3 axis. (from Virology/molecular microbiology)
Liu Hongyang; Xue Mengdi; Feng Chunying; Yu Jimin; Ye Guangqiang — Journal of virology 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK

Details a novel negative regulator (ANXA2) of the cGAS-STING-TBK1/IKKε-IRF3 axis central to the BLUE loop IFN-I pathway implicated in SAMHD1 haploinsufficiency pathophysiology, though not disease-specific.
DOI: 10.1128/jvi.02081-25

Loss of cGAS facilitates angiogenesis in diabetic foot ulcer healing by suppressing the STING/ferroptosis pathway. (from Endocrinology/Wound Healing (Diabetic Foot Ulcer))
Li Wei; Kang Mengyang; Zhang Guofeng; Hu Huishe; Qin Hao — International immunopharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target

Demonstrates cGAS-STING-TBK1-IRF3-NFkB axis driving pathology (ferroptosis, angiogenesis suppression) in a metabolic/vascular disease context, offering mechanistic and therapeutic parallels relevant to the interferon-mitochondrial syndrome's core signaling loop though not SAMHD1-specific.
DOI: 10.1016/j.intimp.2026.116684

EXOC5/SEC10 attenuates antiviral IFN-I signaling by targeting STING1 for autophagic degradation. (from Virology/molecular cell biology (autophagy trafficking))
Ma Wenqing; Xu Yanan; Yu Jie; Sun Fachao; Yu Xiao — Autophagy 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

Describes a novel negative-feedback regulator (EXOC5-TRIM56-STING1-SQSTM1 autophagic degradation axis) of the cGAS-STING/IFN-I pathway central to the BLUE loop, offering mechanistic and therapeutic insight relevant to interferon dysregulation but not SAMHD1-specific.
DOI: 10.1080/15548627.2026.2659292

Emodin alleviates radiation-induced pulmonary fibrosis by targeting cellular senescence via the mtDNA-cGAS-STING axis. (from Pulmonology/radiation oncology)
Duan Wei; Sha Yanling; Tang Xi; Liu Riu; Su Bin — 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK, mito-ROS-NF-kB, treatment-target

Demonstrates mtDNA leakage-driven cGAS-STING-NF-κB activation and mitochondrial ROS as drivers of senescence/fibrosis, directly paralleling the BLUE/RED loop mechanisms in the SAMHD1 syndrome and offering a pharmacologic (emodin) precedent for pathway-targeted intervention.
DOI: 10.1007/s10522-026-10472-7

The novel PARP-1 inhibitor BMMP-TSC bridges mitochondrial dysfunction and innate immunity via mtDNA leakage and cGAS-STING to suppress breast cancer. (from Oncology/pharmacology (PARP-inhibitor drug development))
Wang Nan; Huang Jianting; Fei Fengshu; Ma Shiyu; Fu Qianlong — 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target

Demonstrates mtDNA leakage-driven cGAS-STING activation from mitochondrial damage in a cancer context, mechanistically parallel to the BLUE loop but in an oncology/PARP-inhibitor setting rather than SAMHD1-driven interferonopathy.
DOI: 10.1016/j.cbi.2026.112247

Neutrophil extracellular traps in gout, rheumatoid arthritis, and systemic lupus erythematosus: Mechanistic heterogeneity and therapeutic implications. (from Rheumatology)
Chen Haixu; Liu Xia; Guo Changying; Song Chao; Zeng Lianlin — Tissue & cell 2026
Score: 5/10 | Pathways: NLRP3, urate-NLRP3, cGAS-STING, clinical-phenotype

Discusses ox-mtDNA-driven cGAS/STING/IFN-I and NLRP3 activation in gout/RA/SLE, mechanistically parallel to the GOLD/BLUE loops and relevant to the family's rheumatoid arthritis and gout-adjacent phenotypes, though NETosis is not directly implicated in the SAMHD1 mechanism.
DOI: 10.1016/j.tice.2026.103735

Selective induction of mitochondrial fragmentation for cancer immunotherapy via mtDNA-Targeting AIE photosensitizer. (from Oncology/photodynamic nanomedicine)
Wang Wen-Jin; Hao Ying-Xin; Wang Yu-Meng; Xin Zhuo-Yang; Zhang Man — Biomaterials 2026
Score: 5/10 | Pathways: NLRP3, VDAC1, treatment-target

Demonstrates mtDNA release via mitochondrial permeability transition triggering NLRP3-GSDMD pyroptosis, mechanistically overlapping with the disease's Loop A/B mitochondrial-inflammasome axis, but in a cancer photodynamic therapy context rather than SAMHD1 biology.
DOI: 10.1016/j.biomaterials.2026.124211

Targeting Cathepsin B with p-coumaric acid rescues WWP1-dependent proteasomal degradation of NLRP3 in hyperuricemic nephropathy. (from Nephrology/pharmacology)
Li Fengqin; Wang Yanzhe; Liu Xia; Wu Yue; Miao Naijun — Molecular medicine (Cambridge, Mass.) 2026
Score: 5/10 | Pathways: NLRP3, urate-NLRP3, treatment-target

This paper details a urate/NLRP3-driven nephropathy mechanism (GOLD stream analog) and a novel NLRP3 proteasomal degradation pathway, offering an adjacent but non-interferon mechanistic link and a potential therapeutic angle relevant to the gout/uric acid axis in the disease profile.
DOI: 10.1186/s10020-026-01544-y

Exploration of the Potential Mechanism of Clematichinenoside AR in Alleviating Hyperuricemia Based on Untargeted Metabolomics and Nrf2 Signaling Pathway. (from Pharmacology/Nephrology (traditional Chinese medicine metabolomics))
Liang Qi; Lu Heng; Dong Hongjing; Yu Jinqian; Li Tao — Rapid communications in mass spectrometry : RCM 2026
Score: 5/10 | Pathways: NLRP3, urate-NLRP3, treatment-target

This paper demonstrates the GOLD pathway (purine catabolism → uric acid → NLRP3) mechanistically via a natural compound reducing xanthine oxidase, uric acid, and NLRP3/Caspase-1 activation, relevant to the SAMHD1 syndrome's independent gout/urate-NLRP3 axis but not SAMHD1-specific.
DOI: 10.1002/rcm.70109

Lorlatinib protects dopaminergic neurons by inhibiting ALK-mediated neuroinflammation in a mouse model of Parkinson's disease. (from Neurology/Parkinson's disease pharmacology)
Kim Do-Yeon; Kim Seong-Eun; Park Jung-Eun; Leem Yea-Hyun; Park Jin-Sun — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026
Score: 5/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target

Demonstrates STING-TBK1-IRF3/NF-κB neuroinflammatory axis and microglial activation in a neurodegeneration model, mechanistically overlapping with the interferon-NF-κB crosstalk relevant to the SAMHD1 syndrome's neurological/AuDHD phenotypes, though not SAMHD1-specific.
DOI: 10.1016/j.biopha.2026.119596

Pharmacological inhibition of STING-TBK1 signaling is associated with reduced PANoptosis-like features and fibrotic remodeling in keloids. (from Dermatology/plastic surgery (fibroproliferative skin disorders))
Wang Xinyue; Tian Yuan; Luo Sai; Zhu Wenwen; Zhu Yangdong — International immunopharmacology 2026
Score: 5/10 | Pathways: cGAS-STING, treatment-target, other

Demonstrates STING-TBK1-IRF3 signaling driving inflammatory programmed cell death and fibrosis in keloids, offering a tangential mechanistic parallel (STING/TBK1 activation and pharmacological inhibition) but no direct link to SAMHD1, mitochondrial dNTP dysregulation, or the family phenotype spectrum.
DOI: 10.1016/j.intimp.2026.116869

Saturated mutagenesis screen of M-MLV reverse transcriptase identifies variants enhancing prime editing efficiency (from Molecular biology/genome engineering)
Li Hui; Wang Yifan; Zhang Chenxin; Tun Thi Thi; Yu Shi — preprint (preprint) 2026
Score: 5/10 | Pathways: prime-editing, gene-therapy-delivery

This paper improves prime editing efficiency via M-MLV RT engineering, a generic gene-correction technology platform relevant to future correction of the SAMHD1 A565T missense variant but with no immune/myeloid cell-type specificity or disease-specific demonstration.
DOI: 10.64898/2026.07.06.736660

Systematic profiling of PE6 variants establishes generalizable principles for efficient and specific prime editing (from genome engineering/molecular biology)
Shin Kyuwon; Shin Ju-Young; Woo Aram; Han Dabin; Lee Beomjun — preprint (preprint) 2026
Score: 5/10 | Pathways: prime-editing, gene-therapy-delivery

This paper advances prime editing efficiency/specificity (PE6 variants, DeepPrime6), a generalizable gene-correction technology platform potentially applicable to correcting the SAMHD1 A565T missense variant but not disease-specific or immune-cell targeted.
DOI: 10.21203/rs.3.rs-10000319/v1

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

Targeted Treatment for Hyperuricemia: The Drug Pipeline. (from Rheumatology/geriatrics (gout pharmacotherapy))
Barry Austin; Helget Lindsay N; Mikuls Ted R — Drugs & aging 2026
Score: 4/10 | Pathways: urate-NLRP3, treatment-target

This is a clinical gout pharmacology review touching the GOLD pathway (uric acid/NLRP3) and NLRP3-targeted therapy but does not address SAMHD1, dGTP-driven purine catabolism, or interferon-mitochondrial mechanisms specifically.
DOI: 10.1007/s40266-026-01313-w

The Dual Role of Exosomes in Gout: From Inflammatory Amplifiers to Therapeutic Regulators. (from Rheumatology)
Gao Xuege; Zhang Jiawei; Kong Xiaojuan; Xue Yanli; Fan Weimin — Inflammation 2026
Score: 4/10 | Pathways: urate-NLRP3, NLRP3

Discusses MSU crystal-driven NLRP3 inflammation and exosome biomarkers in gout, touching the GOLD stream endpoint but without SAMHD1, IFN, or mitochondrial mechanistic linkage.
DOI: 10.1007/s10753-026-02551-1

Emapalumab plus conventional therapy with or without ruxolitinib for pediatric hemophagocytic lymphohistiocytosis: a single center retrospective study. (from pediatric hematology-oncology)
Liao Meiling; Xiao Li; Gu Min; Yu Jie — Immunologic research 2026
Score: 4/10 | Pathways: JAK-STAT, treatment-target

Describes ruxolitinib (JAK1/2 inhibitor) use in a hyperinflammatory cytokine syndrome (HLH), tangentially relevant to JAK-STAT/IFN pathway therapeutics but not directly tied to SAMHD1 mechanism or family phenotypes.
DOI: 10.1007/s12026-026-09801-2

Two novel kindreds with autosomal recessive STAT2 deficiency. (from Pediatric immunology/infectious disease (inborn errors of immunity))
Kienapfel Verena; Cresens Lotte; Bizien Lucy; Vasconcelos Julia; Chbihi Marwa — Journal of human immunity 2026
Score: 4/10 | Pathways: JAK-STAT, treatment-target

STAT2 deficiency is a downstream node of the same type I IFN/JAK-STAT axis relevant to the interferonopathy mechanism and uses ruxolitinib as in the family's proposed treatment context, but is a distinct autosomal recessive disease unrelated to SAMHD1 haploinsufficiency.
DOI: 10.70962/jhi.20260037

The role of NLRP3 inflammasome in opioid-induced neurochemical markers, therapeutic effects, and adverse effects in male mice. (from Neuropharmacology/addiction medicine)
Rodriguez Myosotys; Veeragoni Dileepkumar; Carbajal Candy; Owens Florida; Eans S — Brain, behavior, and immunity 2026
Score: 4/10 | Pathways: NLRP3, NF-kB-NLRP3-priming, treatment-target

This paper demonstrates NLRP3/NF-kB/MAPK-driven neuroinflammation and MCC950 efficacy in an opioid model, offering mechanistic and pharmacological parallels (MCC950 as NLRP3 inhibitor) but no direct SAMHD1, interferon, or mitochondrial dNTP connection.
DOI: 10.1016/j.bbi.2026.106528

Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice. (from Mitochondrial genetics/aging biology)
Wu Shilan; Lujan Scott A; Burkholder Adam B; Nissanka Nadee; Longley Matthew J — Nucleic acids research 2026
Score: 4/10 | Pathways: POLG-mtDNA, other

Demonstrates POLG exonuclease-deficiency driving large mtDNA deletions/rearrangements and premature aging, mechanistically adjacent to the PURPLE pathway's POLG-stalling/ox-mtDNA node but without any SAMHD1, dNTP pool, or immune signaling connection.
DOI: 10.1093/nar/gkag648

Precision gene editing: From proof-of-concept to curative therapies. (from Gene therapy/genetic medicine)
Cui Tongtong; Li Bojin; Cai Bingyu; Wang Hui; Li Wei — Trends in molecular medicine 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

General review of precision gene editing technologies and clinical translation with no specific mention of SAMHD1 or immune/myeloid cell targeting relevant to correcting a het missense variant like A565T.
DOI: 10.1016/j.molmed.2026.06.004

Prime editing-mediated microhomology enables efficient replacement of large DNA. (from Genome engineering / synthetic biology)
Xie Yuyang; Li Pan; He Zhiyong; Huang Honglin; Wu Dingzhou — Nucleic acids research 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

This describes a general-purpose prime editing method for large DNA replacement without disease-specific or immune/myeloid cell application, offering only generic future relevance to correcting the SAMHD1 A565T variant.
DOI: 10.1093/nar/gkag626

Emerging frontiers in genome editing: From CRISPR to next-generation technologies. (from Molecular biology/biotechnology (genome engineering))
Mishra Saurabh; Rehan Samrah; Barekzai Ahmad Mujtaba; Sharma Ambika; Raghav Alok — Methods (San Diego, Calif.) 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

A general review of genome editing technologies (CRISPR, base/prime editing, delivery systems) with only broad, non-specific relevance to future SAMHD1 A565T correction strategies rather than direct mechanistic or clinical data.
DOI: 10.1016/j.ymeth.2026.05.011

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to-activator motif switch in the HBG1/2 promoters. (from Hematology/gene therapy)
Chalumeau Anne; Antoniou Panagiotis; Bou Dames Maria; Martinucci Pierre; Retana * — Molecular therapy. Nucleic acids 2026
Score: 4/10* | Pathways: gene-therapy-delivery, prime-editing

Demonstrates prime-editing and CRISPR-HDR correction in HSPCs for sickle cell disease, offering methodological relevance to future SAMHD1 missense correction strategies but no direct SAMHD1/interferon-mitochondrial pathway connection.
DOI: 10.1016/j.omtn.2026.102974

Enhancing prime editing by fusing polymerase substrate-binding proteins to reverse transcriptase. (from molecular genome engineering / biochemistry)
Zhao Dongdong; Wang Ting; Zhang Lu; Sha Taixin; Zhao Xiumei — Nucleic acids research 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery

This paper describes a general prime editing efficiency improvement (PSBP fusion to RT) without any immune/myeloid cell targeting or SAMHD1-relevant application, making it only tangentially relevant as a generic gene-correction technology platform.
DOI: 10.1093/nar/gkag657

Naja atra SVPLA<sub>2</sub> upregulates hexokinase 2-driven macrophage M1 polarization via the cGAS-STING signaling activation. (from Toxicology/venom pharmacology)
Liu Jiahao; Wen Zejing; Tang Sunkun; Wu Jiajia; Han Xinyi — 2026
Score: 4/10 | Pathways: cGAS-STING, other

Demonstrates mtDNA release triggering cGAS-STING pathway activation in macrophages, mechanistically parallel to the BLUE loop but in an unrelated snake venom toxicology context with no SAMHD1 or NLRP3/interferonopathy linkage.
DOI: 10.1016/j.toxicon.2026.109208

The NF-κB-driven inflammatory cascade in ischemic stroke: Linking DAMPs, inflammasomes, and neurovascular dysfunction. (from Neurology/stroke)
Liu Yuan; Zhang Yun — Gene 2026
Score: 3/10 | Pathways: NLRP3, NF-kB-IKK, cGAS-STING

This is a general ischemic stroke NF-κB/inflammasome review with overlapping pathway components (STING, NLRP3, mtDNA DAMPs) but no connection to SAMHD1, dNTP metabolism, or the family phenotype spectrum.
DOI: 10.1016/j.gene.2026.150163

CGRP-uric acid axis in migraine: A redox-inflammatory framework linking neurovascular signaling and metabolic regulation. (from Neurology (headache/migraine medicine))
Lu Chien-Lin; Cheng Yu-Chen; Lu Kuo-Cheng — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026
Score: 3/10 | Pathways: urate-NLRP3, other

This migraine-focused review discusses uric acid/NLRP3/ROS/NF-kB convergence in a neurovascular context, touching the GOLD pathway (urate-NLRP3) but with no SAMHD1, interferon, or mitochondrial dNTP relevance and no clear link to the family phenotype spectrum.
DOI: 10.1016/j.biopha.2026.119709

Exploring the anti-gout mechanism of Erding granules based on network pharmacology and experimental verification. (from traditional Chinese medicine/pharmacology)
Wang Guanglei; He Liang; Zhang Yihua; Tao Xikai — Pakistan journal of pharmaceutical sciences 2026
Score: 3/10 | Pathways: urate-NLRP3

Paper links MSU-induced NLRP3/IL-1β/IL-18 release to a herbal formula via INSR/PRKCA/IGF1R signaling, touching the GOLD pathway (uric acid-NLRP3) but with no SAMHD1, interferon, or mitochondrial dNTP connection.
DOI: 10.36721/PJPS.2026.39.8.232.1

Interpretable machine learning model using peripheral blood for non-invasive detection of moderate-to-severe myelofibrosis in JAK2 V617F-positive MPNs: A multicentre pilot proof-of-concept study. (from Hematology/Oncology (myeloproliferative neoplasms))
Hao Zhuanghui; Song Miaoke; Wang Huichao; Yan Congrui; Cao Shuhua — British journal of haematology 2026
Score: 3/10 | Pathways: NLRP3, treatment-target

IL-1β/NLRP3 involvement in JAK2-mutant myelofibrosis and ruxolitinib response is tangentially related to the interferon-inflammasome axis but concerns a distinct disease (MPN) and gene (JAK2) unrelated to SAMHD1 haploinsufficiency.
DOI: 10.1111/bjh.70552

CD28+ CD8+ Tem cells with a STAT1-dependent glucocorticoid receptor deficit contribute to steroid-refractory acute GVHD. (from Transplant hematology/immunology)
Pan Zengkai; Deng Yujun; Huang Jingtao; Bian Haoxing; Chen Yiyin — Blood 2026
Score: 3/10 | Pathways: JAK-STAT, treatment-target

This paper describes STAT1-GR crosstalk and JAK inhibition in steroid-refractory GVHD, a peripheral JAK-STAT/inflammation mechanism sharing pathway components (STAT1, ruxolitinib) but with no direct link to SAMHD1, cGAS-STING, NLRP3, or mitochondrial dNTP biology.
DOI: 10.1182/blood.2025032587

Metagenomic profiling of gut microbiome in post-cholecystectomy patients with diarrhea: a nested case-control study. (from Gastroenterology/microbiome research)
Ye Jiayi; Mao Peiyu; Li Bo; Hao Ying; Chen Yuwen — BMC microbiology 2026
Score: 3/10 | Pathways: clinical-phenotype

Cholecystectomy clustering is a tracked family phenotype but this paper's gut microbiome/diarrhea findings have no direct mechanistic link to SAMHD1, interferon, or inflammasome pathways.
DOI: 10.1186/s12866-026-05346-4

Maternal gut microbiota mediates prenatal stress-induced fetal blood‒brain barrier dysfunction. (from Obstetrics/neurodevelopmental microbiome research)
Wang Xuanping; Zhou Fang-Yue; Wu Ting; Duan Chenchi; Luo Xukai — Gut microbes 2026
Score: 3/10 | Pathways: pregnancy-fetal, JAK-STAT, other

This paper involves IFN-β signaling and maternal-fetal axis relevant tangentially to interferonopathy biology but lacks any SAMHD1, cGAS-STING, NLRP3, or mitochondrial dNTP mechanism connection.
DOI: 10.1080/19490976.2026.2631242

Targeting the ATX-LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways. (from Oncology (renal cell carcinoma/tumor immunology))
Luo Jinchen; Lin Hansen; Feng Haoqian; Tan Lei; Liu Xi — Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026
Score: 3/10 | Pathways: treatment-target, other

This paper concerns TBK1/IRF3-mediated PD-L1 upregulation in renal cell carcinoma via the ATX-LPA axis, touching the TBK1/IRF3 node shared with the interferonopathy mechanism but in an oncology/immune-evasion context unrelated to SAMHD1 dNTPase biology or mitochondrial dysfunction.
DOI: 10.1002/advs.76352

A novel role of circCPSF6 regulating antiviral innate immunity via miR-665 and PCBP2-IPS-1 axis in IAV infection. (from Virology/RNA biology)
Meher Aparna; Chaudhary Riya; Kumar Himanshu — Molecular therapy. Nucleic acids 2026
Score: 3/10 | Pathways: JAK-STAT, other

This paper describes circRNA-mediated regulation of antiviral IFN signaling (MyD88/STAT2/IKKε/IPS-1) in influenza infection, tangentially touching IFN-I pathway machinery but with no direct SAMHD1, mitochondrial, NLRP3, or inflammasome connection.
DOI: 10.1016/j.omtn.2026.102973

[Effect of electroacupuncture on acute gastric mucosal injury in mice by regulating macrophage polarization mediated by the cGAS-STING signaling pathway]. (from Traditional Chinese medicine / acupuncture research in gastroenterology)
Xu Yuan-Bo; Wang Jing-Ji; Gao Qiu-Jin; Xu Xin-Yue; He Ruo-Nan — Zhen ci yan jiu = Acupuncture research 2026
Score: 3/10 | Pathways: cGAS-STING, other

Uses cGAS-STING signaling terminology but in an unrelated context (electroacupuncture treatment of ethanol-induced gastric mucosal injury and macrophage polarization), with no connection to SAMHD1, mitochondrial dNTP dysregulation, or the interferon-mitochondrial syndrome described.
DOI: 10.13702/j.1000-0607.20251161

Immune cell-intrinsic STING activation drives tumor ferroptosis via AA-mediated suppression of ACSL4 lactylation in colorectal cancer. (from Oncology (colorectal cancer immunometabolism))
Ding Lina; Du Wenqi; Zhu Jing; Zhang Yuxiang; Wang Xingyue — Proceedings of the National Academy of Sciences of the United States of America 2026
Score: 3/10 | Pathways: cGAS-STING, other

This paper uses STING signaling in an oncology/ferroptosis context unrelated to SAMHD1, mitochondrial dNTP dysregulation, or interferonopathy syndrome mechanisms, though it touches the STING node relevant to the broader pathway architecture.
DOI: 10.1073/pnas.2524594123

Smart-responsive lentinan-DMXAA conjugate for synergistic STING-mediated pancreatic cancer immunotherapy. (from Oncology/pharmaceutical nanomedicine)
Zhang Zhengxian; Zhu Xin; Cui Jingru; Han Jiale; Wang Jiaxing — International journal of pharmaceutics 2026
Score: 3/10 | Pathways: cGAS-STING, treatment-target

This is a drug-delivery oncology paper exploiting STING agonism (TBK1-IRF3-IFN-beta) for pancreatic cancer immunotherapy, sharing the STING pathway node but with no SAMHD1, mitochondrial, or NLRP3 connection to the syndrome mechanism.
DOI: 10.1016/j.ijpharm.2026.126996

Cellular hnRNP D promotes influenza A virus replication by inhibiting TBK1-IRF3-mediated innate immune response. (from virology/molecular virology)
Xu Chenchen; Peng Yunling; Liu Shuhui; Xie Ran; Feng Duanchenxi — Journal of virology 2026
Score: 3/10 | Pathways: cGAS-STING, other

This paper describes TBK1-IRF3 antagonism by an influenza viral evasion protein, touching the cGAS-STING/IFN-I axis but with no connection to SAMHD1, mitochondrial dNTP pools, or NLRP3 pathways central to this disease.
DOI: 10.1128/jvi.00257-26

Breaking the oncogene-immune suppression cycle through dual HER2 silencing and innate immune activation by biomineralized DNA nanocomplexes. (from Oncology/nanomedicine drug delivery)
Duan Yubei; Huang Jiaxin; Huang Tianping; Yang Kaige; Qi Liwen — Journal of controlled release : official journal of the Controlled Release Society 2026
Score: 3/10 | Pathways: cGAS-STING

Involves cGAS-STING pathway activation but in a cancer nanomedicine context unrelated to SAMHD1 dNTPase biology, mitochondrial dysfunction, or the family phenotype spectrum.
DOI: 10.1016/j.jconrel.2026.115009

The TRIM27/STING Axis Mediates Schisandrin B-Induced Inhibition of Myeloid-Derived Suppressor Cells Accumulation to Potentiate Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma. (from Oncology/immunotherapy)
Huang Lei; Li Siying; Li Ziqing; Qin Zhuo; Sun Yanan — Phytotherapy research : PTR 2026
Score: 3/10 | Pathways: cGAS-STING, other

Involves STING pathway regulation via TRIM27 in cancer immunotherapy context, but focuses on tumor microenvironment/MDSCs in HCC rather than SAMHD1-driven interferonopathy or mitochondrial dysfunction mechanisms.
DOI: 10.1002/ptr.70368

Scoparone inhibits the progression of gastric cancer by regulating the PIN1/STING/TBK1/IRF3 signaling pathway. (from Oncology/pharmacology)
Zhao Na; Wang Ping — Toxicology and applied pharmacology 2026
Score: 3/10 | Pathways: cGAS-STING

Involves STING/TBK1/IRF3 signaling but in the context of gastric cancer drug mechanism unrelated to SAMHD1 or interferonopathy pathophysiology, with STING activation here being tumor-suppressive rather than pathogenic.
DOI: 10.1016/j.taap.2026.117838

Transglutaminase 2 regulates innate immunity: mechanisms and therapeutic implications. (from biochemistry/enzymology (transglutaminase))
D'Eletto Manuela; Occhigrossi Luca; Colasuonno Fiorella; Bellanca Veronica; Di S — Oncoimmunology 2026
Score: 3/10 | Pathways: cGAS-STING, other

TG2 modulation of TBK1/type I interferon signaling touches tangentially on the IFN-I axis but has no direct connection to SAMHD1, dNTPase, NLRP3, or mitochondrial mechanisms central to this disease profile.
DOI: 10.1080/2162402X.2026.2665505

Viral Infections and Neurodegenerative Diseases: Reinterpreting the Crosstalk Through a Dual-Role Lens. (from neurology/virology gene therapy engineering)
Tahmtan Alireza; Nissapatorn Veeranoot; Saravanabhavan Shanmuga Sundar; Taherkha — Current microbiology 2026
Score: 3/10 | Pathways: gene-therapy-delivery, other

Reviews viral contributions to neurodegeneration and viral vector gene therapy technology broadly, with only tangential overlap to SAMHD1 interferonopathy mechanisms (mitochondrial dysfunction, neuroinflammation) and general gene-editing delivery methods rather than myeloid-targeted correction.
DOI: 10.1007/s00284-026-05018-6

Nanomaterials for subcellular organelle targeting: unlocking new avenues for enhanced therapeutic effectiveness. (from Nanomedicine/drug delivery)
Solouki Kiarash; Sohail Muhammad — Journal of drug targeting 2026
Score: 3/10 | Pathways: gene-therapy-delivery, other

General nanomaterial organelle-targeting review with brief mention of CRISPR/base/prime editing delivery, but no disease-specific mechanistic link to SAMHD1 pathways.
DOI: 10.1080/1061186X.2026.2691784

Re-balancing immunity with CRISPR-Cas9: Novel strategies for cancer and autoimmune disorders. (from genome editing/biotechnology)
Ren Xuanqi; Zhou Ziyang; Kong Lingkai; Guo Yibo; Liu Yan — Biotechnology advances 2026
Score: 3/10 | Pathways: prime-editing, gene-therapy-delivery, other

General review of CRISPR-Cas9 strategies (KO/KI/CRISPRa/CRISPRi/base/prime editing) for cancer and autoimmunity is only tangentially relevant as background on gene-editing tools without any SAMHD1, interferon, or mitochondrial pathway content.
DOI: 10.1016/j.biotechadv.2026.108921

Strategies and Advances in Site-Specific Integration of Exogenous Large Genes. (from Genome engineering/gene therapy methodology)
Wu Zhencheng; Chen Jia; Huang Manqi; Hu Wenqi; Liu Yiyu — Human gene therapy 2026
Score: 3/10 | Pathways: gene-therapy-delivery, prime-editing

This is a general review of large-fragment genomic integration technologies (HDR, prime editing/recombinases, CRISPR transposition) with no specific application to SAMHD1 correction or immune/myeloid cell delivery context relevant to this family's disease.
DOI: 10.1177/10430342261445050

Prime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses. (from Cardiology/gene-editing methodology)
Kim Min Woo; Park Jeong Hwan; Lee Myeonghee; Lee Seul-Gi; Oh Jeong-Seop — Life sciences 2026
Score: 3/10 | Pathways: prime-editing

This paper demonstrates PE7 prime editing to create an isogenic iPSC-cardiomyocyte channelopathy model, relevant only as a generic gene-editing methodology reference and not to SAMHD1 or immune-mitochondrial pathways.
DOI: 10.1016/j.lfs.2026.124573

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease. (from Neurology/regenerative medicine (gene editing methodology transferable to future SAMHD1 correction strategies))
Yan Qing; Xu Chongchong; Gao Jiangmei; Wang Pu; Wu Qingling — Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026
Score: 3/10 | Pathways: prime-editing

Uses prime editing to correct LRRK2 mutations in iPSC-derived dopaminergic cells for Parkinson's disease, demonstrating gene correction feasibility but unrelated to SAMHD1 mechanism or interferon-mitochondrial pathways.
DOI: 10.1002/advs.76394

Generation and characterization of four iPSC and isogenic gene-corrected lines from Legius syndrome patients. (from stem cell/genetic disease modeling)
der Auweraer Seppe Van; Roth Moritz B; Vlahos Katerina; Howden Sara E; Lockhart * — Stem cell research 2026
Score: 3/10* | Pathways: prime-editing

This paper describes iPSC modeling and CRISPR/prime editing correction of SPRED1 variants in Legius syndrome, unrelated to SAMHD1 or the described interferon-mitochondrial pathways, though it demonstrates prime editing correction methodology potentially analogous to future SAMHD1 variant correction.
DOI: 10.1016/j.scr.2026.104026

Generation of gene-corrected human isogenic iPSC lines from hypertrophic cardiomyopathy patients harboring PRKAG2 mutation (c.2084A>G, p.His530Arg) using prime editing. (from Cardiology / stem cell gene editing)
Lu Zijun; Qiu Zhichao; Zhang Yao; Yang Hao; Yang Yuan — Stem cell research 2026
Score: 3/10 | Pathways: prime-editing

Uses prime editing to correct a heterozygous missense mutation causing a distinct cardiomyopathy (PRKAG2), offering only generic technical analogy to potential SAMHD1 A565T correction strategies rather than direct disease relevance.
DOI: 10.1016/j.scr.2026.104008

New Gene Therapy Strategy for β-Thalassemia. (from Hematology/gene therapy)
Liang Dongguo; Schmidt-Wolf Ingo G H; Pu Jingjing — Stem cell reviews and reports 2026
Score: 3/10 | Pathways: gene-therapy-delivery

Reviews base/prime editing for β-thalassemia gene correction, which is a technology platform of theoretical relevance to future SAMHD1 correction strategies but has no direct mechanistic or clinical overlap with the SAMHD1 interferon-mitochondrial syndrome.
DOI: 10.1007/s12015-026-11132-6

A versatile VLP-mediated CRISPR-RNP platform for precise genome editing and durable epigenome silencing in cancer. (from Oncology/gene therapy delivery engineering)
Ju Sungjin; Lee Jang Hyeon; Yang Jiyun; Jeong Tae Yeong; Choi Chang Geun — Molecular therapy. Nucleic acids 2026
Score: 3/10 | Pathways: gene-therapy-delivery

This paper describes a VLP-CRISPR-RNP delivery platform for cancer genome/epigenome editing, relevant only tangentially as a generic delivery technology rather than targeting SAMHD1 correction or immune/myeloid cells specifically.
DOI: 10.1016/j.omtn.2026.102978

Protein Nanocages as Versatile Vectors for Nucleic Acid Delivery: Main Systems and Their Loading Mechanisms. (from nanobiotechnology/bioengineering)
Coffeen Carlos Francisco; Hernández-Gutiérrez Aquetzali Estefanía; Bustos-Jaimes — Molecular biotechnology 2026
Score: 3/10 | Pathways: gene-therapy-delivery

General review of protein nanocage delivery platforms for nucleic acids without specific application to myeloid/immune cells or SAMHD1 correction, only tangentially relevant to future gene therapy translation.
DOI: 10.1007/s12033-026-01564-3

In Utero Gene Therapy for Sickle Cell Disease: Current Evidence, Ethical Considerations, and Future Directions-A Scoping Review. (from Hematology/gene therapy)
Cudjoe Efe; Thorsen Margaret; Molokwu Nneka; Russo Melissa — Clinical therapeutics 2026
Score: 3/10 | Pathways: gene-therapy-delivery, pregnancy-fetal

Discusses in utero gene editing/LNP delivery technology relevant to future SAMHD1 correction strategies but focuses on an unrelated monogenic disease (SCD) with no interferonopathy or mitochondrial mechanism overlap.
DOI: 10.1016/j.clinthera.2026.04.026

Optimizing twin prime editing components for scalable genome editing and therapy in spinocerebellar ataxia type 3. (from Neurology/genetic engineering (gene therapy technology development))
Gwon Lee Wha; Seong Jung Bae; Yeo Hyeon-Gu; Oh Yeounsun; Park Junghyung — Molecular therapy. Nucleic acids 2026
Score: 3/10 | Pathways: prime-editing, gene-therapy-delivery

This paper describes twin prime editing optimization for polyQ deletion in SCA3, a general gene-editing technology advance not targeted to SAMHD1, myeloid cells, or immune correction relevant to the disease profile.
DOI: 10.1016/j.omtn.2026.102988

CRISPR-Cas9 Therapeutics in Diabetes Mellitus: From Molecular Mechanisms and Pharmacology to Clinical Development and Translational Barriers (from Endocrinology/diabetes gene therapy)
Kumar Sachin; Singh Harshit; Sharan Lokesh; Jawa Hemangi; Chaturvedi Saurabh — preprint (preprint) 2026
Score: 3/10 | Pathways: prime-editing, gene-therapy-delivery

This paper discusses CRISPR/base/prime editing therapeutics for diabetes with no direct link to SAMHD1 mechanisms, interferonopathy, or the family's mitochondrial-inflammatory phenotype, though it touches generically on gene editing delivery platforms relevant to future SAMHD1 correction strategies.
DOI: 10.22541/authorea.15004994/v1

Pathway Coverage This Week

  • treatment-target: 43 papers
  • cGAS-STING: 36 papers
  • NLRP3: 24 papers
  • other: 19 papers
  • gene-therapy-delivery: 17 papers
  • prime-editing: 15 papers
  • NF-kB-IKK: 12 papers
  • urate-NLRP3: 12 papers
  • mito-ROS-NF-kB: 9 papers
  • JAK-STAT: 9 papers
  • clinical-phenotype: 7 papers
  • AGS-spectrum: 6 papers
  • VDAC1: 4 papers
  • nucleotide-rewiring: 2 papers
  • POLG-mtDNA: 2 papers
  • NF-kB-NLRP3-priming: 2 papers
  • pregnancy-fetal: 2 papers
  • mito-dNTP-transport: 1 papers
  • dNTPase: 1 papers
  • ISG15-mitophagy: 1 papers

SAMHD1 Research Digest — 2026-07-05

Generated by samhd1_monitor | Model: claude-sonnet-4-6

Summary: 8 papers evaluated | 4 high-relevance (≥7) | 3 medium (5–6) | 1 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Added to Zotero automatically

Early brain-penetrant immunotherapy reverses interferon signature and improves motor outcome in a case of ADAR1-related Aicardi-Goutières syndrome. (from Pediatric Neurology / Neuroimmunology)
Dale Russell C; Hayes Jessica; Han Velda X; Dissanayake Ruwani; Lau Xianzhong — 2026
Score: 8/10 | Pathways: cGAS-STING, JAK-STAT, ISG15-mitophagy, AGS-spectrum, treatment-target, clinical-phenotype

This paper directly demonstrates reversal of the type I interferon signature (including downregulation of CGAS, SAMHD1, ISG15, and JAK1) by ruxolitinib + dexamethasone in an AGS interferonopathy, with single-cell RNA-seq validating the same core molecular players central to the SAMHD1 A565T disease mechanism, and provides a clinically actionable brain-penetrant JAK-inhibitor treatment precedent directly applicable to the interferon-driven neurodevelopmental and ME/CFS phenotypes in this family.
DOI: 10.1002/cti2.70113

JAK Inhibition in <i>PNPT1</i>-Related Mitochondrial Interferonopathy: A Case Report and Review of Mitochondrial-Immune Crosstalk. (from Pediatric neurology / mitochondrial medicine)
Brooks Dan Ross; Koh Hyun Yong; Kerrins Taylor Martin; Lang Steven; Bland Emily — 2026
Score: 8/10 | Pathways: cGAS-STING, JAK-STAT, AGS-spectrum, POLG-mtDNA, ISG15-mitophagy, treatment-target, clinical-phenotype

This case report directly demonstrates JAK inhibitor (tofacitinib) efficacy in a mitochondrial interferonopathy caused by mt-dsRNA cytosolic leakage activating IFN-I signaling—mechanistically parallel to the SAMHD1 A565T pathway where VDAC1 macropore releases mtDNA to activate cGAS-STING-IRF3-IFN-I-JAK-STAT, and provides clinical proof-of-concept that JAK inhibition can normalize IFN signature and downstream pathology (dystonia, lactate, transaminases) in mitochondrial-immune crosstalk syndromes including AGS-spectrum disease.
DOI: 10.1002/jmd2.70096

Aicardi-Goutières Syndrome: Insights from a Middle Eastern Case Series. (from Pediatric Neurology / Neuroradiology)
Alwalid Osamah; Al Subhi Marwa; Al Serhan Ala Aldeen; Abdulwahhab Saja B; Samran — 2026
Score: 7/10 | Pathways: AGS-spectrum, dNTPase, cGAS-STING, clinical-phenotype, JAK-STAT

This case series directly characterizes SAMHD1-associated AGS in a clinical cohort, including two siblings with a homozygous SAMHD1 variant presenting with chronic arthritis but no neurological disease—a phenotype highly relevant to understanding the genotype-phenotype spectrum of SAMHD1 variants and validating the arthritis/interferonopathy axis central to the family phenotype described.
DOI: 10.3174/ajnr.a9239

SLC30A9-mediated mitochondrial zinc homeostasis drives osteosarcoma chemoresistance by suppressing the mtDNA-cGAS-STING pathway. (from Oncology (osteosarcoma/cancer biology))
Li Hongyu; Yang Biao; Liu Yinliang; Yang Wen; Yu Haoye — 2026
Score: 7/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, treatment-target, other

This paper mechanistically demonstrates that mitochondrial dysfunction → mtDNA cytosolic release via mPTP opening → cGAS-STING activation, directly paralleling the BLUE stream (VDAC1/mtDNA/cGAS-STING axis) central to SAMHD1 haploinsufficiency pathology, and introduces a novel upstream regulator (mitochondrial zinc homeostasis via SLC30A9) of this pathway with therapeutic implications, though the context is osteosarcoma chemoresistance rather than interferonopathy.
DOI: 10.1016/j.lfs.2026.124555

🟡 Medium Relevance (Score 5–6)

Review and add to Zotero manually if warranted

Myeloid STING restrains cardiac remodeling by suppressing macrophage amyloid precursor protein (from Cardiology)
Natarajan Niranjana; Johny Ebin; Sriram Varsha; Hara Mika; Antwi Praise Ama — 2026
Score: 6/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, other

This paper directly demonstrates mtDNA release activating cGAS-STING in cardiac macrophages and reveals a cardioprotective STING-MZF1-APP axis, which is mechanistically adjacent to the BLUE stream (VDAC1→mtDNA→cGAS→STING→IRF3) and relevant to the cardiology phenotype dimension of the disease profile, though the STING function here is tissue-protective rather than interferonopathic and SAMHD1 is not mentioned.
DOI: 10.64898/2026.07.01.735895

Daphnetin alleviates influenza pneumonia by enhancing chaperone-mediated autophagy of KEAP1 through Heat shock cognate 71 kDa protein. (from Pulmonology / natural product pharmacology)
Wang Jian; Liu Huan; Pan Xuanhao; Liu Tianyu; Li Qianyuan — 2026
Score: 6/10 | Pathways: cGAS-STING, POLG-mtDNA, mTOR-lysosomal, treatment-target, ME-CFS, other

This paper directly demonstrates that mtDNA leakage activates cGAS-STING inflammation in macrophages during viral pneumonia, and describes a therapeutic axis (HSC70-CMA-NRF2) that mitigates mitochondrial oxidative stress and mtDNA escape—mechanistically adjacent to the BLUE and RED streams of the SAMHD1 interferonopathy model—with potential relevance to the post-viral (ME/CFS) and cGAS-STING-driven IFN-I amplification loops, though SAMHD1, VDAC1, NLRP3, ISG15, or dNTP biology are not addressed.
DOI: 10.1016/j.phymed.2026.158517

Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss. (from Bone biology / osteoporosis / geriatrics)
Li Lingling; Li Xinsai; Jin Mingming; Zhang Yangyang; Bai Jia — 2026
Score: 5/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, other

This paper demonstrates that mtDNA cytosolic escape activates cGAS-STING-NF-κB to drive cellular senescence, directly implicating the BLUE-stream mechanism central to SAMHD1 haploinsufficiency pathology, but in an osteoblast/bone-loss context with no connection to SAMHD1, interferonopathy, or the family's specific phenotypes.
DOI: 10.1007/s00223-026-01567-x

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

The mitochondrial protease, LonP1, is a potential cardioprotective target for attenuating doxorubicin-induced cardiomyocyte death. (from Cardiology/Oncology)
O'Dwyer Kienan P; Bauer Perry E; Dziadowicz Sebastian A; Pal Subhankhi; Eminhize — 2026
Score: 4/10 | Pathways: POLG-mtDNA, cGAS-STING, VDAC1, clinical-phenotype, other

This paper addresses mtDNA release from damaged mitochondria activating inflammatory and apoptotic signaling (relevant to the BLUE/PURPLE streams via cytosolic mtDNA → cGAS-STING and VDAC1 macropore concepts), but the context is doxorubicin cardiotoxicity and LonP1 protease biology rather than SAMHD1 haploinsufficiency, interferonopathy, or any core family pathway, making the connection tangential despite mechanistic overlap in mtDNA leakage.
DOI: 10.1186/s12967-026-08537-9

Pathway Coverage This Week

  • cGAS-STING: 8 papers
  • POLG-mtDNA: 6 papers
  • other: 5 papers
  • treatment-target: 4 papers
  • clinical-phenotype: 4 papers
  • VDAC1: 4 papers
  • JAK-STAT: 3 papers
  • AGS-spectrum: 3 papers
  • ISG15-mitophagy: 2 papers
  • dNTPase: 1 papers
  • mTOR-lysosomal: 1 papers
  • ME-CFS: 1 papers

SAMHD1 Research Digest — 2026-06-28

Generated by samhd1_monitor | Model: claude-sonnet-4-6

Summary: 12 papers evaluated | 6 high-relevance (≥7) | 5 medium (5–6) | 1 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Added to Zotero automatically

Fibroblast Mitochondrial Ca2+ Overload Drives Skin Fibrosis via mtDNA Leakage and cGAS-STING Activation in Systemic Sclerosis. (from Rheumatology/connective tissue disease (systemic sclerosis))
Zhang Xiaoyun; Wang Yingyu; Huang Hai; Guo Xinyi; Ye Wenjing — 2026
Score: 8/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, treatment-target, other

This paper directly demonstrates the VDAC1 oligomerization → cytosolic mtDNA leakage → cGAS-STING activation axis in a fibrotic disease context, mechanistically validating the BLUE stream of the SAMHD1 haploinsufficiency model, and identifies VDAC1 inhibition and STING inhibition (H-151) as therapeutic targets with in vivo efficacy—highly actionable for the treatment-target framework.
DOI: 10.1002/art.70261

Delphinidin targets voltage-dependent anion channel 1 to inhibit ferroptosis and protect against retinal photochemical damage. (from Ophthalmology/retinal biology)
Wang Hansheng; Li Keyi; Pu Haomou; Xiong Yaoyao; Luo Dan — 2026
Score: 8/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, treatment-target

This paper directly demonstrates the VDAC1 oligomerization → cytosolic mtDNA leakage → cGAS-STING activation axis that is central to the BLUE stream of the disease mechanism, and identifies delphinidin as a direct VDAC1-targeting compound that interrupts this cascade, making it highly relevant as both a mechanistic validation and a potential therapeutic lead analogous to VBIT-4.
DOI: 10.1016/j.phymed.2026.158455

Interrupting a mitochondrial DNA-driven innate immune circuit attenuates hepatic tissue remodeling and fibrotic architecture in experimental steatohepatitis. (from Hepatology)
Hamad Rabab S; Mohammed Sura Akram; Hasan Waseem Ali; AbuoHashish Norhan Ahmed; * — 2026
Score: 8/10* | Pathways: cGAS-STING, NLRP3, ISG15-mitophagy, IRF7-metabolic, POLG-mtDNA, treatment-target, clinical-phenotype

This paper directly interrogates the mtDNA-cGAS-STING-IRF3-IFN-β axis combined with NLRP3/IL-1β inflammasome and mitophagy (PINK1/Parkin) blockade in a metabolic liver disease model—mapping precisely onto the BLUE, RED, and PURPLE mechanistic streams of the SAMHD1 A565T interferonopathy, and demonstrating that dual upstream (mitophagy enhancement via urolithin A) plus downstream (STING inhibition via C176) targeting produces synergistic multi-domain control, providing directly translatable therapeutic logic for the hepatic steatosis phenotype documented in the family.
DOI: 10.1016/j.tice.2026.103733

Mitochondria-associated endoplasmic reticulum membrane (MAM): roles in innate immunity dysregulation. (from Cell biology / organelle biology)
Zhang Qingqi; Gao Junyan; Yang Yiting; Guo Ping; Gao Huiqin — 2026
Score: 8/10 | Pathways: cGAS-STING, NLRP3, VDAC1, ISG15-mitophagy, POLG-mtDNA, treatment-target

This review directly covers the MAM as a hub integrating cGAS-STING activation, NLRP3 inflammasome, mtDNA release via mitochondrial fission/fusion dynamics, and mitophagy/autophagy flux—all four core pathways (PURPLE, BLUE, RED, GOLD) of the SAMHD1 A565T disease mechanism—and explicitly identifies the self-reinforcing cycle between MAM dysfunction and innate immune overactivation that underlies the proposed interferonopathy, making it highly mechanistically relevant even without direct SAMHD1 mention.
DOI: 10.1186/s12964-026-03013-9

Suppression of STING by Acacetin attenuates renal fibrosis via balancing mitophagy and protective nucleoid-phagy. (from Nephrology/Traditional Chinese Medicine pharmacology)
Gao Yujiu; Mu Linjie; Liu Chen; Zhao Yue; Cai Rui — 2026
Score: 7/10 | Pathways: cGAS-STING, ISG15-mitophagy, VDAC1, treatment-target, mTOR-lysosomal

This paper directly investigates STING inhibition restoring mitophagy flux and mitochondrial quality control in a fibrotic context, directly relevant to the BLUE and RED pathway loops where cGAS-STING activation and mitophagy blockade drive the interferonopathy cycle in SAMHD1 haploinsufficiency; Acacetin's direct STING binding (Kd=1.57µM) and restoration of autophagic/mitophagic flux represent a novel small-molecule treatment-target insight.
DOI: 10.1016/j.jep.2026.122094

A negative regulator of mitochondrial complex I assembly adapts respiration to cellular energy demand. (from Mitochondrial cell biology / bioenergetics)
Li Zhirong; Chen Nuo; Zhou Caixia; Xu Lingna; Wang Xiyuan — 2026
Score: 7/10 | Pathways: cGAS-STING, POLG-mtDNA, VDAC1, other

TMEM141 regulates Complex I assembly and its deficiency causes oxidative mtDNA damage and mtDNA release activating cGAS-STING, directly engaging the BLUE stream of the disease mechanism where cytosolic mtDNA fragments drive cGAS→STING→IRF3→IFN-I, while the Complex I/OXPHOS connection links to the mitochondrial dysfunction central to the PURPLE and RED streams, offering a novel regulatory node (TMEM141/TIMMDC1/AFG3L2/YME1L1 axis) upstream of mtDNA escape.
DOI: 10.1016/j.molcel.2026.06.018

🟡 Medium Relevance (Score 5–6)

Review and add to Zotero manually if warranted

Role and mechanism of nitric oxide-regulated cGAS/STING pathway-mediated inflammatory response in hypoglycemia-induced coronary artery endothelial cell injury. (from Cardiology/Endocrinology)
Luo Wenping; Wei Xiao; Xiao Qian — 2026
Score: 6/10 | Pathways: cGAS-STING, POLG-mtDNA, VDAC1, clinical-phenotype, treatment-target

This paper demonstrates a mechanistic link between mitochondrial damage, mtDNA release, and cGAS/STING pathway activation in coronary endothelial cells—directly overlapping with the BLUE and PURPLE streams of the SAMHD1 haploinsufficiency model—and validates STING inhibition as a cardioprotective strategy, which is relevant to the cardiology clinical context of the family phenotype.
DOI: 10.1371/journal.pone.0350983

cGAS-STING Pathway Mediates Retinal Pigmental Epithelial Dysfunction in Diabetic Retinopathy. (from Ophthalmology/Retinal medicine)
Zhu Zhaoqi; Qiu Aowang; Wang Ningyu; Zhu Ziyu; Yin Wenjie — 2026
Score: 6/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, treatment-target

This paper directly demonstrates the mechanistic link between mitochondrial DNA leakage, cGAS-STING pathway activation, and downstream inflammation in a non-immune tissue context, validating the BLUE stream mechanism (mtDNA → cGAS → STING → inflammation) and showing STING inhibition as a pharmacological strategy, which is highly relevant to the core interferonopathy mechanism of SAMHD1 haploinsufficiency, though the disease context (diabetic retinopathy) is not directly related to the family phenotype.
DOI: 10.2337/db25-0128

GPAM mediates mitochondrial dysfunction and the progression of alcoholic liver disease through lipid remodeling. (from Hepatology)
Zhan Zibin; Liu Xuewen; Li Zehua; Qiao Xueyan; Li Shuo — 2026
Score: 6/10 | Pathways: cGAS-STING, ISG15-mitophagy, VDAC1, NLRP3, clinical-phenotype

This paper directly demonstrates that ceramide accumulation and cardiolipin loss disrupt mitochondrial dynamics and impair mitophagy, releasing mitochondrial DNA that activates cGAS-STING-driven inflammation—mechanistically mirroring the BLUE and RED pathway streams in SAMHD1 haploinsufficiency, and invoking ceramide (a named molecular player) alongside impaired mitophagy, though the context is alcoholic liver disease rather than interferonopathy.
DOI: 10.1126/sciadv.aef1896

Neuronal YTHDF2 suppresses innate immune activation in Aβ pathology by promoting m<sup>6</sup>A-dependent decay of cytosolic mitochondrial mRNAs. (from Neuroscience/Alzheimer's disease research)
Pan Wenqi; Yang Lin; Zhang Yao; Chen Yan; Xu Yuesi — 2026
Score: 6/10 | Pathways: cGAS-STING, JAK-STAT, ME-CFS, AGS-spectrum, other

This paper describes cytosolic mitochondrial RNA fragments activating innate immune signaling (RIG-I-MAVS → IFN-β → JAK-STAT neuroinflammation), a parallel mechanism to the VDAC1/cGAS-STING axis in the disease profile where cytosolic mt-derived nucleic acids drive type I interferon responses, reinforcing the concept that mitochondrial nucleic acid escape is a convergent driver of interferonopathy relevant to the SAMHD1 syndrome's neurological and inflammatory phenotypes.
DOI: 10.1126/sciadv.adz0887

RBM10 Deficiency Promotes Anti-PD-1 Resistance in LUAD via STING Alternative Splicing-Driven CCL7 Signaling and Macrophage Polarization. (from Oncology/thoracic)
Gao Weitong; Wang Ruqiong; An Bo; Qi Lishuang; Jing Zihan — 2026
Score: 5/10 | Pathways: cGAS-STING, other

This paper identifies a STING alternative splicing mechanism (exon 3 exclusion) that modulates cGAS-STING signaling output and feeds into a mtDNA-cGAS-STING positive feedback loop via mitochondrial transfer, which is adjacent to the BLUE and PURPLE streams of the SAMHD1 A565T disease mechanism, but the context is lung adenocarcinoma immunotherapy resistance rather than interferonopathy or SAMHD1 haploinsufficiency.
DOI: 10.1002/advs.202522159

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

The transcription factor IRF8 drives tumor-specific exhaustion in CD8+ T cells. (from Oncology/Tumor Immunology)
Ongaro Marco; Thouenon Romane; Crespo Isaac; Dumez Alexandre; Charmoy Mélanie — 2026
Score: 3/10 | Pathways: JAK-STAT, other

The paper identifies IRF8 as a tumor-specific regulator of CD8+ T cell exhaustion suppressed by sustained IFN-I signaling, which has indirect relevance to the SAMHD1 disease context via the JAK-STAT/IFN-I axis, but does not engage any core pathways (cGAS-STING, NLRP3, VDAC1, ISG15-mitophagy, dNTPase) and focuses on tumor immunology rather than interferonopathy, mitochondrial dysfunction, or the family phenotypes described.
DOI: 10.1084/jem.20252115

Pathway Coverage This Week

  • cGAS-STING: 11 papers
  • VDAC1: 8 papers
  • POLG-mtDNA: 7 papers
  • treatment-target: 7 papers
  • other: 5 papers
  • ISG15-mitophagy: 4 papers
  • NLRP3: 3 papers
  • clinical-phenotype: 3 papers
  • JAK-STAT: 2 papers
  • IRF7-metabolic: 1 papers
  • mTOR-lysosomal: 1 papers
  • ME-CFS: 1 papers
  • AGS-spectrum: 1 papers

SAMHD1 Research Digest — 2026-06-21

Generated by samhd1_monitor | Model: claude-sonnet-4-6

Summary: 27 papers evaluated | 12 high-relevance (≥7) | 9 medium (5–6) | 6 low (3–4) | 0 scored <3

🔴 High Relevance (Score 7–10)

Added to Zotero automatically

Nucleotide metabolism reprogramming in obesity-associated cardiovascular inflammation: a new perspective (from Cardiology/Immunometabolism)
Taoming Qian; Mei Zhang; Yuhan Liu; Donghao Guo; Juan Jin — Frontiers in Immunology 2026
Score: 9/10 | Pathways: dNTPase, NLRP3, POLG-mtDNA, VDAC1, urate-NLRP3, treatment-target, clinical-phenotype, other

This paper directly models the SAMHD1→dNTP accumulation→mitochondrial dNTP import (SLC25/PNC transporters)→mtDNA oxidation→NLRP3 hyperactivation axis that is the core PURPLE and GOLD mechanism of the disease profile, demonstrating it in a cardiovascular/macrophage context with therapeutic node identification, making it highly mechanistically relevant even without the specific A565T variant.
DOI: 10.3389/fimmu.2026.1829718

The leaked mitochondrial DNA activated the cGAS-STING signaling pathway and exacerbated the motor dysfunction in mice caused by MPTP. (from Neurology/movement disorders)
Zhu Guangyao; Yu Xuanjie; Guo Yi; Yang Liting; Yang Qianhui — 2026
Score: 8/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, treatment-target, other

This paper directly demonstrates the BLUE stream mechanism central to the disease model: mitochondrial stress → mtDNA leakage into cytosol → cGAS-STING activation → neuroinflammation, and validates STING inhibition as a therapeutic target, with direct relevance to the SAMHD1/VDAC1-mtDNA escape axis even though SAMHD1 is not mentioned.
DOI: 10.1016/j.expneurol.2026.115876

STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy. (from Cell biology / mitochondrial quality control)
Zebo Huang; Jin-Yi Lin; Ling-Jun Cheng; Yong Wu; Xiangzheng Gao — Cell reports 2026
Score: 8/10 | Pathways: cGAS-STING, ISG15-mitophagy, VDAC1, POLG-mtDNA, mTOR-lysosomal, treatment-target

This paper directly implicates the cGAS-STING pathway as an upstream regulator of mitophagy via TBK1-OPTN signaling, which is mechanistically central to the BLUE and RED streams of the disease model—where constitutive STING activation from VDAC1/mtDNA escape not only drives IFN-I but also perturbs mitochondrial quality control, and the STING-OPTN mitophagy axis disruption switches cells toward apoptosis, directly mirroring the double mitophagy block (ISGylation of MFN1/2 and BECN1) and the apoptosis-autophagy switch (BIK/BH3) predicted in the family's pathomechanism.
DOI: 10.1016/j.celrep.2026.117515

STING1 senses mitochondrial damage to promote mitophagy. (from Cell biology / autophagy)
Zebo Huang; Jin-Yi Lin; Ling-Jun Cheng; H. Tan; Hanming Shen — Autophagy 2026
Score: 8/10 | Pathways: cGAS-STING, ISG15-mitophagy, POLG-mtDNA, ME-CFS, treatment-target

This paper directly demonstrates that STING1 acts as a non-canonical upstream regulator of PINK1/Parkin-dependent mitophagy via TBK1-OPTN phosphorylation, revealing a critical mechanistic intersection with the RED and BLUE streams of the disease model: in SAMHD1 haploinsufficiency, chronic cGAS-STING activation would simultaneously drive IFN-I (canonical) and dysregulate mitophagy quality control (non-canonical), and disruption of the STING1-TBK1-OPTN axis shifts cell fate toward apoptosis rather than pro-survival mitophagy, directly explaining the double mitophagy block and accumulation of damaged mitochondria central to the family's interferon-mitochondrial syndrome.
DOI: 10.1080/15548627.2026.2689463

cGAS-STING signaling pathway: a central pathological mechanism and emerging therapeutic target for postoperative cognitive dysfunction. (from Anesthesiology/Perioperative Neuroscience)
Wu Xiaoqin; Zhong Baolin; Xu Yongxing; Lai Yinsiqing; Wen Xinming — 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, VDAC1, POLG-mtDNA, ISG15-mitophagy, treatment-target

This review directly describes the mtDNA-cGAS-STING-neuroinflammation axis with pyroptosis and mitophagy failure as central mechanisms, which maps precisely onto the BLUE and RED streams of the SAMHD1 haploinsufficiency model, and identifies cGAS-STING inhibition and mitophagy promotion as therapeutic targets directly applicable to this disease mechanism.
DOI: 10.1016/j.brainres.2026.150432

Runx1-Snx9 axis drives the pathological secretion of mitochondrial-derived vesicles to activate cGAS-STING signaling in acute pancreatitis. (from Gastroenterology/Pancreatology)
Gao Mengqi; Xiao Guohui; Chen Kunhao; Li Shiyu; Chen Cong — 2026
Score: 7/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, NLRP3, other

This paper directly characterizes a novel upstream mechanism (Runx1-Snx9 axis) driving mitochondrial-derived vesicle secretion and mtDNA release that activates macrophage cGAS-STING signaling — the same BLUE stream pathway central to SAMHD1 haploinsufficiency — providing a mechanistic parallel for how cytosolic/extracellular mtDNA fragments trigger chronic interferon activation, even though the context is acute pancreatitis rather than SAMHD1 dysfunction.
DOI: 10.1186/s12951-026-04687-6

Environmental enrichment mitigates sevoflurane-induced neurodevelopmental injury via cGAS-STING-dependent microglial modulation. (from Pediatric anesthesiology/neurodevelopment)
Li Feixiang; Gong Bingqing; Wu Haiyan; Yang Yongyan; Luo Ying — 2026
Score: 7/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, ME-CFS, other

This paper directly demonstrates the mitochondrial dysfunction → mtDNA release → cGAS-STING activation → microglial neuroinflammation → synaptic/cognitive impairment axis, which is mechanistically identical to the BLUE stream in the SAMHD1 haploinsufficiency model, and validates mtDNA-driven cGAS-STING as a tractable intervention target in a neurodevelopmental context relevant to the AuDHD phenotype in the proband.
DOI: 10.1186/s13578-026-01610-2

Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease. (from Mitochondrial biology / proteostasis)
Xie Lin; Wu Li-Hong; Ni Xin-Cheng; Zhang Jiang-Nan — 2026
Score: 7/10 | Pathways: cGAS-STING, POLG-mtDNA, NLRP3, VDAC1, mTOR-lysosomal, ME-CFS, treatment-target, other

LONP1 directly regulates mtDNA maintenance and its deficiency triggers mtDNA release activating cGAS-STING—the BLUE stream core mechanism in this disease—while also modulating metabolic enzymes relevant to the mitochondrial-inflammatory convergence and SARS-CoV-2 pathogenesis relevant to ME/CFS post-viral trigger, making this a high-value adjacent mechanism with novel treatment implications.
DOI: 10.1016/j.bcp.2026.118170

Mitophagy in Macrophages: A Metabolic Checkpoint in Inflammation-to-Repair Transition in Atherosclerosis. (from Cardiology/atherosclerosis)
Jie Zhou; Hanxiu Liu; Sen Ma; Haoyang Wang; Ni He — Journal of the American Heart Association 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, VDAC1, ISG15-mitophagy, treatment-target, POLG-mtDNA

This review directly covers the RED and BLUE stream mechanisms—PINK1/Parkin mitophagy block, mtDNA release activating cGAS-STING and NLRP3 inflammasome in macrophages—with therapeutic targets (metformin, resveratrol, MCC950-analogous NLRP3 inhibition) that map precisely onto the ISG15-mitophagy double-block and VDAC1-cGAS-STING axes central to the SAMHD1 haploinsufficiency syndrome, though SAMHD1 itself is not mentioned.
DOI: 10.1161/jaha.125.048103

The COX2-PGE2-PKA Axis Suppresses Antiviral Immunity by Inhibiting mtDNA-Dependent STING Activation (from Virology/innate immunity (HSV-1 infection model))
P. Vo; Julien Cicero; Zichen Wang; Hiroyuki Hakozaki; Thomas S. Hoang — bioRxiv 2026
Score: 7/10 | Pathways: cGAS-STING, POLG-mtDNA, ISG15-mitophagy, ME-CFS, treatment-target

This paper directly addresses the mtDNA-cytosol-cGAS-STING-IFN-I axis (BLUE stream) and mitophagy regulation thereof, revealing that COX2/PGE2/PKA/STOML2 suppresses STING activation by clearing immunostimulatory cytosolic mtDNA via mitophagy—a regulatory circuit highly relevant because in SAMHD1 haploinsufficiency the mtDNA-cGAS-STING pathway is constitutively overactivated and the ISG15/MFN1/MFN2 mitophagy block prevents this clearance, making COX2/PGE2/PKA axis modulation a potential therapeutic lever.
DOI: 10.64898/2026.04.03.716411

Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis (from Cardiology/Vascular biology)
Hao Liu; Shuai Zhao; Huiqin Gao; Yue Wang; Junyan Gao — Precision Clinical Medicine 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, VDAC1, ISG15-mitophagy, JAK-STAT, POLG-mtDNA, treatment-target

This review directly covers the core convergent mechanism of the disease profile—mt-DAMPs (including mtDNA escape via mitochondrial membrane permeability changes analogous to VDAC1 macropore opening) activating cGAS-STING to drive type I interferon production and NLRP3-mediated IL-1β release—while also detailing the PINK1-Parkin mitophagy pathway that is blocked by ISGylation of MFN1/MFN2 in the RED stream, providing mechanistic depth and atherosclerosis-relevant treatment targets applicable to the interferonopathy-mitochondrial syndrome.
DOI: 10.1093/pcmedi/pbag010

Cytosolic Immunostimulatory DNA Ligands and DNA Damage Activate the Integrated Stress Response, Stress Granule Formation, and Cytokine Production (from Cancer immunotherapy / DNA damage biology)
Trupti Devale; Lekhana Katuri; Gauri Mishra; Aditya Acharya; Praveen Manivannan — Cells 2026
Score: 7/10 | Pathways: cGAS-STING, JAK-STAT, ME-CFS, treatment-target, other

This paper directly characterizes the STING-PERK-G3BP1 signaling axis linking cytosolic dsDNA sensing (including mtDNA escape, the core BLUE pathway) to the integrated stress response, stress granule formation, and IFN-I/cytokine production — mechanisms directly downstream of SAMHD1 haploinsufficiency-driven dNTP pool expansion and VDAC1-mediated mtDNA release, and identifies PERK as a novel druggable node that could modulate the chronic interferonopathy in this family.
DOI: 10.3390/cells15020139

🟡 Medium Relevance (Score 5–6)

Review and add to Zotero manually if warranted

Restoring BECN1-Mediated Autophagy Mitigates Acute Lung Injury Caused by Zinc Oxide Nanoparticles. (from Pulmonary toxicology/nanotoxicology)
Lejiao Mao; Meiling Tan; Xuejun Jiang; Jun Zhang; Ge Xu — Free radical biology & medicine 2026
Score: 6/10 | Pathways: ISG15-mitophagy, NLRP3, mTOR-lysosomal, treatment-target

This paper directly demonstrates that BECN1 haploinsufficiency (heterozygous knockout) impairs mitophagy flux causing accumulation of dysfunctional mitochondria, ROS, and inflammatory cascades—mechanistically parallel to the RED stream where ISGylation of BECN1 blocks autophagy flux in the SAMHD1 disease model, and validates Tat-Beclin1 as a pharmacological rescue strategy for BECN1-dependent mitophagy failure.
DOI: 10.1016/j.freeradbiomed.2026.05.317

Immunoglobulin G complexes from post-infectious ME/CFS, including post-COVID ME/CFS disrupt cellular energetics and alter inflammatory marker secretion (from Neuroimmunology/autoimmunity)
Zheng Liu; Claudia Hollmann; S. Kalanidhi; S. Lamer; Andreas Schlosser — Brain, Behavior, & Immunity - Health 2026
Score: 6/10 | Pathways: ME-CFS, VDAC1, ISG15-mitophagy, JAK-STAT, clinical-phenotype, other

This paper directly characterizes ME/CFS (including post-COVID ME/CFS) IgG-mediated mitochondrial fragmentation and energetic disruption in endothelial cells, providing mechanistic autoimmune context for the proband's post-viral ME/CFS phenotype, with mitochondrial fragmentation highly relevant to the ISG15-MFN1/2 mitophagy block and VDAC1 macropore streams in the disease model.
DOI: 10.1016/j.bbih.2026.101187

Interferon stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing (from DNA damage response / genome stability)
Samira Kemiha; Lorena Rejón-Franco; Estelle Ghibaudo; R. Eloiflin; Morgane Chema — The Journal of Biological Chemistry 2026
Score: 6/10 | Pathways: cGAS-STING, POLG-mtDNA, ME-CFS, other

This paper demonstrates that cytoplasmic ISD (the same stimulus generated by VDAC1-mediated mtDNA escape in the BLUE stream) co-activates ATM and DNA-PK damage response kinases independently of cGAS-STING, revealing a parallel DDR arm that could amplify genomic instability and checkpoint activation in SAMHD1 haploinsufficiency where chronic cytosolic dsDNA (from ox-mtDNA fragments) is present.
DOI: 10.1016/j.jbc.2026.111362

African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication. (from Veterinary virology / ASFV vaccinology)
Xiaoxuan Li; Binbin Ren; Danyang Zhang; Miao Dan; Dongying Liu — Autophagy 2026
Score: 6/10 | Pathways: cGAS-STING, ISG15-mitophagy, ME-CFS, other

This paper directly addresses the cGAS-STING pathway and PINK1/Parkin-dependent mitophagy as targets of viral immune evasion—mechanisms central to the SAMHD1 A565T syndrome—demonstrating that mitophagic clearance of TBK1 suppresses type I interferon production, which is the inverse of the constitutive IFN-I overactivation and mitophagy block seen in this family, providing mechanistic insight into how mitophagy flux regulation gates cGAS-STING-IFN-I signaling amplitude.
DOI: 10.1080/15548627.2026.2654982

B33-01 Cisd1 Regulates the Sting Pathway Through the Ubiquitin-proteasome System to Ameliorate COPD Progression (from Pulmonology/COPD)
J. Gao; Y. Song — American Journal of Respiratory and Critical Care Medicine 2026
Score: 6/10 | Pathways: cGAS-STING, JAK-STAT, other

This paper describes a mitochondria-to-STING innate immunity axis where CISD1 (a mitochondrial iron-sulfur protein) regulates STING degradation via K48-ubiquitination through Ubr5, directly engaging the cGAS-STING-TBK1-IRF3 pathway that is a core loop (BLUE) in the SAMHD1 haploinsufficiency mechanism, offering a novel STING regulatory checkpoint (ubiquitin-proteasome degradation) relevant to modulating the chronic interferon signature seen in the family, though SAMHD1 and dNTP biology are not addressed.
DOI: 10.1093/ajrccm/aamag162.1786

Toward a Molecular Reclassification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Integrating Multi-Omics, Machine Learning, and Precision Medicine (from Computational biology / precision medicine / multi-omics)
Joshua Frank; Nicole Nesterovitch; Chetana Movva; N. Klimas; L. Nathanson — International Journal of Molecular Sciences 2026
Score: 6/10 | Pathways: ME-CFS, JAK-STAT, POLG-mtDNA, cGAS-STING, NLRP3, ISG15-mitophagy, treatment-target, other

This review directly addresses ME/CFS molecular reclassification and identifies chronic innate immune activation, mitochondrial dysfunction, and genetic risk variants as core pathophysiology—all of which map onto the SAMHD1 A565T interferon-mitochondrial syndrome mechanism—but does not specifically implicate SAMHD1, cGAS-STING, or the dNTPase axis, making it a high-quality contextual reference for the proband's ME/CFS phenotype rather than a mechanistic confirmation.
DOI: 10.3390/ijms27104436

Ca2+-driven self-amplified nanoplatform targeting ER-mitochondrial calcium crosstalk for synergistic apoptosis induction and tumor immune microenvironment remodeling (from Oncology/nanomedicine)
Yucui Ding; Xinyu Liu; Jianlong Fu; Jianyue Xue; Xueni Fan — Materials Today Bio 2026
Score: 5/10 | Pathways: cGAS-STING, VDAC1, NLRP3, other

The paper directly engages the IP3R-GRP75-VDAC complex, mitochondrial permeability transition, and Mn2+-driven cGAS-STING activation—all mechanistically overlapping with the BLUE and PURPLE streams of the SAMHD1 interferonopathy model—but in an oncology/nanomedicine context with no connection to SAMHD1 haploinsufficiency, dNTP pool dysregulation, or the family's clinical phenotypes.
DOI: 10.1016/j.mtbio.2026.103339

Human Endogenous Retroviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Emerging Roles in Pathogenesis, Immunity, Biomarkers and Therapeutics (from Virology/Retrovirology)
K. D. Perera; E. Oltra; S. Carding — International Journal of Molecular Sciences 2026
Score: 5/10 | Pathways: ME-CFS, cGAS-STING, JAK-STAT, AGS-spectrum, other

The paper addresses ME/CFS pathogenesis through HERV-driven innate immune activation (including cGAS-STING sensing, LTR-driven interferon amplification, and JAK-STAT signaling) which overlaps mechanistically with the IFN-I loop central to SAMHD1 haploinsufficiency syndrome, and HERV reactivation is plausibly potentiated by the dNTP pool expansion that SAMHD1 normally suppresses (since SAMHD1 restricts retrotransposon/HERV reverse transcription), but the paper does not address SAMHD1, VDAC1, NLRP3, mitochondrial pathways, or ISG15-mitophagy directly.
DOI: 10.3390/ijms27104309

Dual-targeting macrophage membrane nanosystem enhances radiotherapy-induced antitumor immunity via synergistic nuclear and mitochondrial DNA damage. (from Oncology/Nanomedicine)
Guangyu Ju; Qi Ding; Hongcang Gu; Rao Liu; Xiao Liu — Biomaterials science 2026
Score: 5/10 | Pathways: cGAS-STING, VDAC1, POLG-mtDNA, JAK-STAT, other

This paper demonstrates that mitochondrial membrane permeabilization (analogous to VDAC1 macropore opening in the BLUE stream) causes cytosolic accumulation of mitochondrial nucleic acids activating innate immune signaling and type I interferon, which mechanistically parallels the SAMHD1/VDAC1-mtDNA-cGAS-STING axis, but the context is engineered radiotherapy enhancement in glioma with no SAMHD1 involvement.
DOI: 10.1039/d6bm00279j

🟢 Low Relevance (Score 3–4)

Potential specialty bridges — skim titles

TFEB-mediated autophagy dysregulation links with PRPF31 deficiency-induced photoreceptor death via PLK4 downregulation. (from Ophthalmology/retinal genetics)
Lujia Zhang; Yuntao Qu; S. Yao; Luying Han; Guangming Liu — Experimental eye research 2026
Score: 4/10 | Pathways: mTOR-lysosomal, other

This paper describes a haploinsufficiency-driven autophagic hyperactivation and mitochondrial dysfunction cascade (PLK4-TFEB axis) that shares conceptual overlap with the lysosomal/autophagy failure and mitochondrial damage themes in the SAMHD1 syndrome, but involves entirely different genes (PRPF31, PLK4, TFEB) in a retinal degeneration context with no connection to interferon signaling, dNTP metabolism, cGAS-STING, or any other core SAMHD1 pathway.
DOI: 10.1016/j.exer.2026.111000

C-terminal tail of MAVS dictates organelle targeting and innate immune response (from Cell biology / virology)
Terence Lee; Kiki Cham; Dong-Yan Jin — Cell Communication and Signaling : CCS 2026
Score: 4/10 | Pathways: cGAS-STING, other

MAVS organelle-specific signaling is upstream of IRF3/IFN-β activation (a convergent endpoint in the BLUE stream), but this paper addresses RNA sensing via RIG-I-like receptors rather than the cGAS-STING/VDAC1-mtDNA axis central to SAMHD1 haploinsufficiency, making the connection tangential despite sharing IRF3 and type I interferon as readouts.
DOI: 10.1186/s12964-026-02753-y

Perturbation of RNA homeostasis impairs mitochondrial respiration during poxvirus infection through excess RNA accumulation. (from Virology/RNA biology)
Djamal Brahim Belhaouari; Anil Pant; Santiago Navarro-Forero; Fernando Cantu; Zh — Proceedings of the National Academy of Sciences of the United States of America 2026
Score: 4/10 | Pathways: POLG-mtDNA, ME-CFS, other

This paper reveals an interferon-independent mechanism by which RNA accumulation directly impairs mitochondrial membrane potential and respiration, which is tangentially relevant as the SAMHD1 haploinsufficiency model involves mitochondrial dysfunction, but the paper's core mechanism (excess RNA perturbing mitochondria during poxvirus infection) is not a primary pathway in the SAMHD1 A565T disease model and involves no direct overlap with cGAS-STING, VDAC1, ISG15, NLRP3, or dNTPase axes.
DOI: 10.1073/pnas.2605194123

Genetic and transcriptomic signatures of host control in HIV-1 infection. (from Infectious disease / virology)
Oreshkov Sergey; Thorball Christian W; Meylan Jenny; Muriset Maude; Calmy Alexan — 2026
Score: 3/10 | Pathways: dNTPase, other

This paper identifies SAMHD1 as an HIV-1 restriction factor counteracted by Vpx in passing, but focuses on transcriptomic correlates of HIV load control rather than SAMHD1 dNTPase function, haploinsufficiency, or the cGAS-STING/interferonopathy/mitochondrial pathways central to the disease profile.
DOI: 10.1186/s12977-026-00679-4

Degradable STING nanomodulators orchestrate the innate-to-adaptive immune response for NIR-II photothermal-immunotherapy via a cancer-immunity cycle (from Nanomedicine/oncology)
Qiaolin Wei; Zirui Zhu; Yue Li; Siying Sun; Ge Gao — Materials Today Bio 2026
Score: 3/10 | Pathways: cGAS-STING, other

While this paper involves cGAS-STING pathway activation, it does so in the context of engineered cancer nanoparticle immunotherapy using exogenous Zn2+/ROS/photothermal stimulation in solid tumors, with no mechanistic relevance to SAMHD1 haploinsufficiency, endogenous dNTP pool dysregulation, interferonopathy, or any of the family's clinical phenotypes.
DOI: 10.1016/j.mtbio.2026.103028

Bispecific Macrophage Nano-Engager Couples Dual Checkpoint Blockade with Stimulator of Interferon Genes Activation to Potentiate Antitumor Immunity. (from Oncology/Nanomedicine)
Bao-Toan Dang; Khang-Yen Pham; Huyen T. Le; Thoa Thi Kim Nguyen; A. T. Vu — ACS nano 2026
Score: 3/10 | Pathways: cGAS-STING, JAK-STAT, other

This paper activates STING pharmacologically (SR717 agonist) in a tumor immunotherapy context, which is mechanistically opposite to the disease profile where cGAS-STING is pathologically overactivated by cytosolic mtDNA fragments; the paper's engagement with STING/IFN pathways is incidental to its oncology focus and offers no direct mechanistic insight into SAMHD1 haploinsufficiency or the interferonopathy cascade.
DOI: 10.1021/acsnano.6c01144

Pathway Coverage This Week

  • cGAS-STING: 21 papers
  • other: 20 papers
  • POLG-mtDNA: 15 papers
  • VDAC1: 12 papers
  • treatment-target: 12 papers
  • ME-CFS: 11 papers
  • ISG15-mitophagy: 10 papers
  • NLRP3: 9 papers
  • JAK-STAT: 8 papers
  • mTOR-lysosomal: 4 papers
  • dNTPase: 2 papers
  • clinical-phenotype: 2 papers
  • urate-NLRP3: 1 papers
  • AGS-spectrum: 1 papers