SAMHD1 Research Digest — 2026-07-18¶
Generated by samhd1_monitor | Model: claude-sonnet-5
Summary: 35 papers evaluated | 6 high-relevance (≥7) | 17 medium (5–6) | 12 low (3–4) | 0 scored <3
🔴 High Relevance (Score 7–10)¶
Auto-added to Zotero (threshold ≥6)
Transition Metal Activation Reframes SAMHD1 Regulation. (from biochemistry/metalloenzyme spectroscopy)
Calderone Logan A; Gizzi Anthony; Pinninti Soumika; Stivers James T; Pandelia Ma — ACS chemical biology 2026
Score: 8/10 | Pathways: dNTPase, treatment-target
This paper directly characterizes the metal cofactor requirements (iron/manganese) for SAMHD1's dNTPase catalytic activity, providing fundamental mechanistic insight into the enzyme whose partial loss-of-function (as in A565T) drives the entire dNTP pool expansion cascade underlying this syndrome.
DOI: 10.1021/acschembio.6c00438
Mitochondrial dynamics and metabolic regulation in cellular inflammation: From mechanisms to precision therapeutics. (from Pharmacology/mitochondrial cell biology)
Park Woo Hyun — Pharmacology & therapeutics 2026
Score: 8/10 | Pathways: NLRP3, cGAS-STING, mito-dNTP-transport, nucleotide-rewiring, treatment-target, VDAC1
Directly engages ox-mtDNA/cGAS-STING/NLRP3 activation via mitochondrial dynamics and explicitly discusses the YME1L-SLC25A33 pyrimidine-imbalance axis, closely paralleling the PNC1/2 nucleotide-carrier mechanism central to the disease model.
DOI: 10.1016/j.pharmthera.2026.109086
MGMT deficiency augments STING-mediated inflammatory responses accompanied by metabolic alterations in macrophages. (from DNA repair biology / cancer genetics)
Kongkavitoon Pornrat; Boonmee Atsadang; Pattarakankul Thitiporn; Wongprom Benjaw — Scientific reports 2026
Score: 7/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target, other
Demonstrates that DNA repair deficiency (MGMT) amplifies STING-TBK1-IRF3 signaling and mitochondrial oxidative metabolism in macrophages, directly relevant to the interferon-mitochondrial crosstalk (cGAS-STING/IRF3, mitochondrial respiration, DNA damage) central to the SAMHD1 syndrome's BLUE/RED loops.
DOI: 10.1038/s41598-026-62431-4
The Development of UM-232, a Covalent STING Antagonist. (from Medicinal chemistry/drug discovery)
Barasa Leonard; DeOrsey Leo; O'Reilly Maeve D; Cahill Sara E; Choudhary Shruti — ACS medicinal chemistry letters 2026
Score: 7/10 | Pathways: cGAS-STING, treatment-target
Describes a novel covalent STING antagonist directly targeting the cGAS-STING axis (Loop A) that drives the IFN-I overproduction central to this SAMHD1 haploinsufficiency syndrome, offering potential therapeutic relevance despite no direct SAMHD1 data.
DOI: 10.1021/acsmedchemlett.6c00114
Electroacupuncture alleviates spinal cord injury by regulating M2-like polarization of myeloid cells through CMPK2/NLRP3 inflammasome inhibition. (from Neurology/Rehabilitation (spinal cord injury, acupuncture))
Zhang Kai; Zhang Mengru; Chen Yi; Ni Ziao; Huang Yi — International immunopharmacology 2026
Score: 7/10 | Pathways: NLRP3, mito-dNTp-transport, nucleotide-rewiring, treatment-target
This paper directly implicates CMPK2 as a regulator of NLRP3 inflammasome activation and myeloid polarization, mechanistically connecting the CMPK2-dependent mitochondrial dNTP salvage pathway (a key node in the SAMHD1/PNC1/PNC2 nucleotide-rewiring model) to NLRP3-driven neuroinflammation, offering a non-obvious cross-context validation of the CMPK2/NLRP3 axis relevant to the SAMHD1 haploinsufficiency mechanism.
DOI: 10.1016/j.intimp.2026.116989
Mitochondrial DNA efflux as a potential amplifier of systemic inflammatory network rewiring in heart failure with preserved ejection fraction (from Cardiology)
Xingwei Zhao; Shengyu Huang; Qiuling Li; Yang Yu; Chunxiang Zhang — Frontiers in Immunology 2026
Score: 7/10 | Pathways: cGAS-STING, NLRP3, NF-kB-NLRP3-priming, POLG-mtDNA, clinical-phenotype, treatment-target
Describes mtDNA release activating cGAS-STING/TLR9 and NLRP3 inflammasome as a cross-organ inflammatory amplifier, directly paralleling the BLUE/Loop A and NLRP3 priming mechanisms in the SAMHD1 syndrome model though in a cardiology (HFpEF) context rather than SAMHD1-driven disease.
DOI: 10.3389/fimmu.2026.1866184
🟡 Medium Relevance (Score 5–6)¶
Score ≥6 auto-added to Zotero; lower scores: review manually
Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production. (from pharmacology/drug repurposing)
Li Yuanhao; Xie Qianqian; Sun Tianyin; Lu Jiwei; Li Mengmeng — Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026
Score: 6/10 | Pathways: NLRP3, mito-ROS-NF-kB, urate-NLRP3, treatment-target
Paper details a mitochondrial ROS-dependent NLRP3 activation mechanism (via chloride efflux/TMEM16F) and MSU-crystal-driven inflammasome activation, both directly paralleling the GOLD (urate-NLRP3) and mito-ROS-NF-kB routes in the disease model, with NFA representing a potential adjunct NLRP3-targeting therapeutic.
DOI: 10.1007/s00011-026-02328-0
Targeting CCDC90B restores intestinal stem cell function under hyperuricemic stress. (from Gastroenterology/stem cell biology)
Peng Xiuying; Li Moxuan; Zeng Kaixuan; Lv Wantong; Huang Shuai — Stem cell reports 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, treatment-target
Demonstrates the GOLD-stream mechanism (uric acid → mitochondrial ROS → NLRP3 activation) directly, relevant to the family's SAMHD1-driven dGTP/purine catabolism route to inflammasome activation, albeit in intestinal stem cells rather than immune cells.
DOI: 10.1016/j.stemcr.2026.102970
Ring-finger protein 5 protects against diabetic kidney disease by targeting and degrading STING. (from Nephrology/Endocrinology (diabetic kidney disease))
Dong Chunping; Sun Yan; Li Hui; Qiao Yuan; Gao Shan — Pathology, research and practice 2026
Score: 6/10 | Pathways: cGAS-STING, NF-kB-IKK, treatment-target
Demonstrates RNF5-mediated ubiquitin degradation of STING suppressing TBK1/IRF3/NF-kB activation and fibrosis in diabetic kidney disease, offering a plausible downstream therapeutic node for the STING/NF-kB arm of the interferon-mitochondrial syndrome despite being in a different clinical context (nephrology/diabetes).
DOI: 10.1016/j.prp.2026.156618
Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches. (from Endocrinology (type 1 diabetes autoimmunity))
Iwaloye Opeoluwa F; Mathews Clayton E; Li Danmeng — Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2026
Score: 6/10 | Pathways: IRF7-metabolic, NF-kB-IKK, treatment-target, clinical-phenotype
MDA5/IFIH1-driven type I interferon signaling via TBK1/IKKε-IRF and NF-κB converges mechanistically with the SAMHD1 cGAS-STING/NF-κB interferonopathy axis and shares therapeutic logic (JAK/IFN pathway targeting) relevant to autoimmune comorbidities in the family phenotype spectrum.
DOI: 10.1177/10799907261467555
Senegenin mitigates neuroinflammation, pyroptosis, and apoptosis in cerebral ischemia via inhibiting STING and downstream inflammatory pathway. (from neurology/stroke pharmacology)
Chauhan Chandan; Kaundal Ravinder K — European journal of pharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, NF-kB-IKK, treatment-target
Demonstrates pharmacological STING-TBK1-IRF3 and NF-κB/NLRP3 pathway inhibition reducing pyroptosis/apoptosis in a disease model, directly relevant to the core Loop A/B mechanism though in an unrelated ischemic stroke context rather than SAMHD1-driven interferonopathy.
DOI: 10.1016/j.ejphar.2026.179147
Dietary riboflavin blocks the cGAS-STING pathway to curb hypoxia-induced hepatic inflammation in sub-adult grass carp (Ctenopharyngodon idella). (from veterinary/aquaculture nutrition science)
Zhong Lin; Feng Lin; Wu Pei; Jiang Weidan; Zhang Hongyun — Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026
Score: 6/10 | Pathways: cGAS-STING, VDAC1, NF-kB-IKK, mito-ROS-NF-kB, treatment-target
This fish study demonstrates VDAC1/mtDNA-driven cGAS-STING-TBK1-IRF3/NF-kB (p-P65) activation causing hepatic inflammation under hypoxia, mirroring the BLUE loop and NF-kB crosstalk mechanisms in the SAMHD1 syndrome, with riboflavin as a mitochondrial-protective therapeutic lever relevant to treatment strategies.
DOI: 10.1016/j.aninu.2026.01.012
Reduced myocardial NRG-1/ErbB4 signaling is associated with STING-linked macrophage pyroptotic signaling in sepsis-induced cardiac injury. (from Cardiology/sepsis)
Wei Yanian; Wang QianWen; Shen Cheng; Pan Xia; Kang Wen — International immunopharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, NF-kB-IKK, treatment-target
This paper demonstrates cGAS-STING-TBK1-IRF3/NF-kB signaling driving macrophage pyroptosis (NLRP3, caspase-1, GSDMD-N) in cardiac injury, directly relevant to the interferon-inflammasome axis and cardiac phenotype seen in the SAMHD1 family, though it lacks any SAMHD1 connection.
DOI: 10.1016/j.intimp.2026.117044
LKB1/ AMPK deficiency aggravates mitochondrial DNA leakage via mTOR-dependent mitophagy damage in liver injury sensitized by trichloroethylene. (from Occupational/environmental toxicology and hepatology)
Zhu Lifu; Wan Chenghuan; Li Zijun; Fan Xuan; Liu Dongsheng — 2026
Score: 6/10 | Pathways: cGAS-STING, mTOR-lysosomal, treatment-target
Demonstrates mitophagy failure leading to mtDNA leakage and cGAS-STING-driven inflammation via LKB1/AMPK/mTOR axis, mechanistically parallel to the mitochondrial-interferon convergence in the SAMHD1 syndrome despite a different toxicological trigger.
DOI: 10.1016/j.cbi.2026.112261
Microglial mitophagy as an immunometabolic checkpoint in alzheimer's disease: linking mitochondrial quality control to neuroinflammation. (from Neurodegeneration/neuroimmunology)
Zou Mingyue; Zhao Tengyu; Wu Weidong; Zhang Jian; Pan Pengyu — 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, ISG15-mitophagy, mTOR-lysosomal, treatment-target
Reviews microglial mitophagy failure driving mtDNA/mtROS-triggered cGAS-STING and NLRP3 activation with TBK1 signaling, mechanistically parallel to the mitochondrial-quality-control/interferon-inflammasome axis central to the SAMHD1 syndrome, though disease context is Alzheimer's rather than SAMHD1.
DOI: 10.1186/s12974-026-03946-5
The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the mouse heart (from Cardio-oncology/pharmacology)
Kelsey H. Fisher-Wellman; Richard D. Lutze; Logan G. Kirkland; J. Beak; Mansi Go — Science Advances 2026
Score: 6/10 | Pathways: cGAS-STING, mito-ROS-NF-kB, treatment-target
Demonstrates mitochondrial DNA damage triggering cGAS-STING innate immune activation via mitochondrial dysfunction and ETC impairment, directly paralleling the BLUE/Loop A mechanism in the SAMHD1 syndrome, though in a drug-cardiotoxicity rather than SAMHD1 context.
DOI: 10.1126/sciadv.aeb2695
The mitochondrial logic of inflammaging: how energy imbalance drives fibroblast SASP and tissue-specific aging (from Geroscience/periodontology)
Yu Huan; Qiqi Wang; Rongkaixuan Fang; Yue Sun; Meiya Suo — Frontiers in Immunology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, NF-kB-IKK, mito-ROS-NF-kB, treatment-target
This paper reviews mitochondrial danger signal (mtROS/mtDNA)-driven cGAS-STING/NLRP3/NF-kB convergence in cellular senescence, mechanistically paralleling the SAMHD1 syndrome's Loop A/B and NF-kB crosstalk axes though in a general aging/periodontal context without SAMHD1 involvement.
DOI: 10.3389/fimmu.2026.1881243
How Redox Modulation May Help Prevent Age-Related Decline (from nutrition/geroscience)
M. Amirova — PHYTONutrients 2026
Score: 6/10 | Pathways: NLRP3, cGAS-STING, NF-kB-IKK, NF-kB-NLRP3-priming, mito-ROS-NF-kB, treatment-target
General review of mitochondrial DAMP-driven cGAS-STING/NLRP3/NF-kB inflammaging and NRF2 antioxidant modulation overlaps mechanistically with the IFN-mitochondrial-inflammasome axis but lacks SAMHD1-specific or dNTP pathway data.
DOI: 10.62368/pn.v5i1.71
Biallelic mutations in SUPV3L1 cause a variable leukodystrophy due to impaired mitochondrial degradosome function (from Neurology/leukodystrophy genetics)
L. Green; Noémie Hamilton; M. Elpidorou; R. Maroofian; Maha S. Zaki — Research Square 2026
Score: 6/10 | Pathways: cGAS-STING, AGS-spectrum, clinical-phenotype
Mitochondrial dsRNA degradosome dysfunction driving type I interferon activation via microglia parallels the SAMHD1-driven mitochondrial-to-interferon signaling axis, though it operates through a distinct RNA-sensing (rather than dNTPase/cGAS-mtDNA) mechanism within the broader interferonopathy spectrum.
DOI: 10.21203/rs.3.rs-4356120/v2
A Multi-Center Integrative Cohort Characterizing the Genetic, Clinical, and Transcriptomic Features of ACP5 Deficiency. (from Rheumatology/genetics (skeletal dysplasia and immune dysregulation))
Zhong Shiling; Ma Shuangyue; El Chazli Yasmine; Zheng Jika; Sun Xiangwei — Arthritis & rheumatology (Hoboken, N.J.) 2026
Score: 5/10 | Pathways: JAK-STAT, NF-kB-IKK, AGS-spectrum, clinical-phenotype, treatment-target
ACP5/SPENCDI is a distinct interferonopathy with overlapping type I IFN, NF-κB, and JAK-STAT signaling and JAK inhibitor treatment response, offering mechanistic and therapeutic parallels to the SAMHD1 interferonopathy spectrum despite being a different causal gene.
DOI: 10.1002/art.70279
Leveraging Mitochondria-Endoplasmic Reticulum Functional Interplay With an On-Demand Nanoparticle to Boost mtDNA-Based STING Immunotherapy. (from Oncology/nanomedicine)
Chen Han; Qu Haijing; Pan Yuqing; Cheng Wei; Wu Jie — Advanced materials (Deerfield Beach, Fla.) 2026
Score: 5/10 | Pathways: cGAS-STING, treatment-target
This paper explores mtDNA-driven cGAS-STING activation via a mitochondria-ER nanoparticle system for cancer immunotherapy, which is mechanistically relevant to the BLUE pathway's mtDNA-cGAS-STING axis but oncology-focused rather than SAMHD1-related.
DOI: 10.1002/adma.74146
CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates a β-thalassemia model. (from Hematology/gene therapy engineering)
Marone Romina; Lepore Rosalba; Paschoudi Kiriaki; Zuin Jessica; Sinopoli Alessan — bioRxiv : the preprint server for biology 2026
Score: 5/10 | Pathways: prime-editing, gene-therapy-delivery
Uses prime editing to engineer epitope-shielded CD34+ HSPCs for toxin-free conditioning, representing a relevant myeloid/HSC gene correction delivery advance analogous to strategies that could correct SAMHD1 missense variants, though disease context (beta-thalassemia) is unrelated to interferonopathy pathways.
DOI: 10.64898/2026.07.07.736903
Base Editing Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of X-Linked Severe Combined Immunodeficiency (from Gene therapy/immunodeficiency)
S. de Ravin; Michelle Ma; Yuzhi Yin; Siyuan Liu; Andrés Zea Vera — Journal of Human Immunity 2026
Score: 5/10 | Pathways: gene-therapy-delivery
Demonstrates base-editing correction of a het/hemizygous immune gene mutation (IL2RG) in HSPCs, relevant as a translational precedent for future SAMHD1 A565T correction strategies but not mechanistically tied to the interferon-mitochondrial-NLRP3 axis.
DOI: 10.70962/pidtc2026abstract.4
🟢 Low Relevance (Score 3–4)¶
Potential specialty bridges — skim titles
Annual gout flare frequency as a marker of sustained cardiovascular risk: a clinical threshold for risk stratification. (from Rheumatology/Cardiology)
Tung Kuei-Ting; Chen Solomon Chih-Cheng; Lee Chun — Rheumatology (Oxford, England) 2026
Score: 4/10 | Pathways: urate-NLRP3, clinical-phenotype
This clinical epidemiology paper links gout flare frequency to cardiovascular risk via cumulative inflammatory burden, tangentially relevant to the GOLD pathway (dGTP-uric acid-MSU crystal-NLRP3 axis) but does not address SAMHD1, interferon, or mitochondrial mechanisms directly.
DOI: 10.1093/rheumatology/keag370
Approach to the patient with APS-1/APECED. (from Endocrinology)
Webb Taura; Pechacek Joseph; Lionakis Michail S — The Journal of clinical endocrinology and metabolism 2026
Score: 4/10 | Pathways: JAK-STAT, clinical-phenotype, other
APS-1/AIRE is a distinct monogenic autoimmune tolerance disorder with IFN-gamma-driven pathology and JAK inhibitor treatment rationale, offering only loose conceptual parallel (JAKi as interferonopathy therapy) but no direct SAMHD1/cGAS-STING/NLRP3 mechanistic overlap.
DOI: 10.1210/clinem/dgag282
MDA5 and the integrated stress response control sex-specific type 1 diabetes onset in NOD mice. (from Endocrinology/diabetes autoimmunity)
Van Dis Erik; DeGidio Alessandra T; Yao Lara; Winship Damion; Sidrauski Carmela — bioRxiv : the preprint server for biology 2026
Score: 4/10 | Pathways: AGS-spectrum, other
This paper links MDA5/IFIH1 and integrated stress response to autoimmune diabetes in the AGS-adjacent RNA-sensing innate immune context, offering tangential mechanistic overlap (nucleic acid sensing driving type I IFN-like pathology) but no direct SAMHD1, cGAS-STING, NLRP3, or mitochondrial dNTP connection.
DOI: 10.64898/2026.07.02.736190
Compound delivery of eVLPs enhances prime editing for targeted genome engineering and high-throughput screening. (from functional genomics/gene editing technology)
Langley Jethro; Baudrier Lou; Curry Jada; Narta Kiran; Todesco Hayley M — Cell genomics 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery
General-purpose eVLP/prime-editing methods advance is technically relevant to future SAMHD1 correction strategies but not targeted to immune/myeloid cells or the disease mechanism itself.
DOI: 10.1016/j.xgen.2026.101302
Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7. (from neurology/gene therapy (Alzheimer's disease))
Kim Yunkyung; Lee Gaeun; An Saemin; Park Hanseul; Kim Hongwon — Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery
This paper demonstrates PE7 prime editing technology for allele-specific correction (APOE4→APOE3) in neurons, offering a technical precedent for correcting heterozygous missense variants like SAMHD1 A565T, but is otherwise unrelated to interferonopathy/SAMHD1 biology or immune cell targeting.
DOI: 10.1002/advs.76658
SARS-CoV-2 ORF9b exploits mitochondrial recruitment to TOMM70 for proteasomal protection and tunes inflammatory remodeling during lung infection (from Virology/Structural Biology)
Yining Zhao; Lauriane Kergoat; Guilherme Dias de Melo; F. Larrous; Guillaume Dru — bioRxiv 2026
Score: 4/10 | Pathways: cGAS-STING, other
This paper explores SARS-CoV-2 ORF9b-mitochondrial (TOMM70) interactions and inflammatory remodeling via a Complex IV subunit substitute, touching on mitochondrial-innate immune crosstalk and interferon regulation but without direct SAMHD1, cGAS-STING, or NLRP3 pathway involvement relevant to the described syndrome.
DOI: 10.64898/2026.07.13.738231
Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives (from biomedical engineering/nanomedicine)
Meijia Yang; Yiqiong Song; Ziyang Wang; Ke Chao; Lifeng Li — MedComm 2026
Score: 4/10 | Pathways: prime-editing, gene-therapy-delivery
General review of genome editing delivery platforms with no SAMHD1-specific or immune/myeloid cell targeting focus, only tangentially relevant as background for future gene correction strategies.
DOI: 10.1002/mco2.70791
Proteomics-based characterization of apigenin-mediated anti-inflammatory effects in TNF-α-stimulated ARPE-19 cells. (from Ophthalmology/pharmacology (flavonoid anti-inflammatory research in retinal disease))
Chen Xi; Liao Meilin; Han Ruifang; Gao Juan; Lu Ping — International immunopharmacology 2026
Score: 3/10 | Pathways: NF-kB-IKK, JAK-STAT, ISG15-mitophagy
This paper studies apigenin's suppression of NF-κB/MAPK signaling and interferon-stimulated proteins (STAT1, ISG15, OAS3, IFIT3) in retinal pigment epithelial cells, touching peripheral pathway nodes (NF-κB, ISG15, IFN-related proteins) relevant to the syndrome's mechanism but with no SAMHD1, mitochondrial, or NLRP3 connection and an unrelated ophthalmologic/pharmacologic context.
DOI: 10.1016/j.intimp.2026.117048
Guiqi Baizhu prescription attenuates 5-FU-induced intestinal mucositis by targeting IKKβ to inhibit M1 macrophage polarization. (from Gastroenterology/Traditional Chinese Medicine oncology supportive care)
Zhou Yu-Cen; Li Ya-Ling; Ma Jing; Li Junjie; Si Qi — Chinese medicine 2026
Score: 3/10 | Pathways: NF-kB-IKK
Paper focuses on IKKβ/NF-κB inhibition in a traditional Chinese medicine model of chemotherapy-induced gut mucositis, only tangentially touching the NF-κB-IKK axis without connection to SAMHD1, interferonopathy, or mitochondrial mechanisms.
DOI: 10.1186/s13020-026-01406-z
Nanoengineering Systems for Gene Therapy: Mechanisms, Modalities, and Future Directions. (from nanotechnology/bioengineering)
Mais Raheem; Kumar Ayush; Ahmetaj Armand; Burgos-Crespo Gaby; Sanchez Mary Marga — International journal of molecular sciences 2026
Score: 3/10 | Pathways: gene-therapy-delivery, prime-editing
General review of nanomaterial delivery platforms for CRISPR/base/prime editing with no SAMHD1, immune cell, or mitochondrial-interferon pathway specificity.
DOI: 10.3390/ijms27135988
Intelligent metal-integrated hydrogels orchestrate pyroptosis and cGAS-STING for potentiated treatment of colorectal cancer peritoneal metastasis. (from Oncology/biomaterials drug delivery)
Zhang Lin-Zhu; Si Liang-Wei; Xu Hui; Xiong Fei; Qin Juan — 2026
Score: 3/10 | Pathways: cGAS-STING, other
Describes cGAS-STING activation via mtDNA/pyroptosis in a cancer-therapeutic (hydrogel/cobalt) context unrelated to SAMHD1 mechanism or family phenotypes, though it touches the same signaling node.
DOI: 10.1016/j.jconrel.2026.115184
Orchestrating the gut microbiota–mitochondrial–immune axis in gynecological diseases: mechanisms and dual-targeting therapeutic strategies (from Gynecology/Reproductive Health)
Haixia Tang; Yiting Zhang; Yanting Wang; Ze Zhou; Rong Sun — Frontiers in Reproductive Health 2026
Score: 3/10 | Pathways: cGAS-STING, NLRP3, other
This review covers gut microbiota-mitochondria-immune crosstalk (cGAS-STING/NLRP3, mtDNA, mitophagy) in gynecological disease but is not connected to SAMHD1, dNTP metabolism, or the family phenotype spectrum.
DOI: 10.3389/frph.2026.1845581
Pathway Coverage This Week¶
treatment-target: 20 paperscGAS-STING: 18 papersNLRP3: 11 papersNF-kB-IKK: 11 papersother: 6 papersclinical-phenotype: 6 papersgene-therapy-delivery: 6 papersmito-ROS-NF-kB: 5 papersprime-editing: 5 papersurate-NLRP3: 3 papersAGS-spectrum: 3 papersJAK-STAT: 3 papersnucleotide-rewiring: 2 papersVDAC1: 2 papersNF-kB-NLRP3-priming: 2 papersmTOR-lysosomal: 2 papersISG15-mitophagy: 2 papersdNTPase: 1 papersmito-dNTP-transport: 1 papersmito-dNTp-transport: 1 papersPOLG-mtDNA: 1 papersIRF7-metabolic: 1 papers