SAMHD1 Research Digest — 2026-07-12¶
Generated by samhd1_monitor | Model: claude-sonnet-5
Summary: 9 papers evaluated | 0 high-relevance (≥7) | 6 medium (5–6) | 3 low (3–4) | 0 scored <3
🟡 Medium Relevance (Score 5–6)¶
Score ≥6 auto-added to Zotero; lower scores: review manually
Abscisic acid ameliorates inflammation-related diseases by inhibiting NLRP3 inflammasome activation. (from pharmacology/natural product chemistry)
Jiao Chenyang; Jia Lulu; Liu Qian; Zhang Weihang; Zhang Wei — International immunopharmacology 2026
Score: 6/10 | Pathways: NLRP3, urate-NLRP3, mTOR-lysosomal, treatment-target
This paper identifies a novel NLRP3 inhibitor (ABA/PDZD8-lysosomal axis) validated in MSU-induced gouty arthritis, directly relevant to the GOLD stream (dGTP→uric acid→MSU crystals→NLRP3) and offers a potential therapeutic strategy for NLRP3 hyperactivation in the syndrome.
DOI: 10.1016/j.intimp.2026.117119
ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype. (from Dermatology/Rheumatology (psoriasis, psoriatic arthritis))
Assan Florence; Tragin Margot; Marella Sahiti; Lipecka Joanna; Roger Kévin — The Journal of experimental medicine 2026
Score: 6/10 | Pathways: JAK-STAT, treatment-target, clinical-phenotype, AGS-spectrum
Monogenic ADAR1 loss-of-function causing constitutive type I IFN signature and inflammatory disease (psoriasis) mirrors the interferonopathy mechanism central to SAMHD1 A565T pathology, and JAK inhibitor (upadacitinib) responsiveness directly parallels proposed treatment strategies for the family syndrome.
DOI: 10.1084/jem.20260054
A micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by attenuating cGAS-STING-type I IFN signaling in macrophages. (from Oncology/tumor immunology)
Wang Xingwen; Zhang Yi; Ma Jiangwen; Lin Qingyu; Wang Zhenghang — Nature cancer 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target
This paper details a novel negative-feedback mechanism (UEIS-TBK1 condensates) directly within the cGAS-STING-TBK1-type I IFN axis in macrophages, a core pathway implicated in the SAMHD1 interferonopathy syndrome, though its focus on tumor immunology rather than SAMHD1/mitochondrial dysfunction limits direct relevance.
DOI: 10.1038/s43018-026-01195-2
STING-associated metabolic changes engage AMPK to amplify interferon signaling in Listeria-infected macrophages. (from Microbiology/infectious disease immunometabolism)
Chen Shukun; Wang Xiao; Duan Zhuoyu; Wang Min; Qu Xiaoya — Biochimica et biophysica acta. Molecular cell research 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, other
Demonstrates STING-driven metabolic reprogramming (glycolysis/AMPK/TBK1) amplifying type I IFN signaling, directly relevant to the STING/IFN-I axis (Loop A) though in a bacterial infection context rather than SAMHD1-driven cGAS-STING activation.
DOI: 10.1016/j.bbamcr.2026.120172
ISG15 At the Crossroads of Innate Immunity and Host Survival in Response to Typhoid Toxin. (from microbiology/infectious disease (Salmonella typhoid toxin biology))
Valenzuela Camila; Enninga Jost — Molecular microbiology 2026
Score: 6/10 | Pathways: cGAS-STING, ISG15-mitophagy, treatment-target
Describes a STING-TBK1-dependent, ISGylation-independent free ISG15 pathway triggered by cytosolic DNA sensing that promotes cell survival, mechanistically parallel to the BLUE/RED axes in the SAMHD1 syndrome even though the trigger is bacterial genotoxin rather than mtDNA leakage.
DOI: 10.1111/mmi.70075
Recent Insights into Mitochondrial Dysfunction-Driven Cellular Senescence in Chronic Kidney Disease (from Nephrology)
Ziyi Guo; Zhenkai Wang; Zixuan Song; Tian Wang; Jingai Fang — BIOCELL 2026
Score: 5/10 | Pathways: NLRP3, cGAS-STING, POLG-mtDNA, treatment-target
Discusses mitochondrial dysfunction driving cGAS-STING/NLRP3-mediated senescence and SASP, mechanistically overlapping with the interferon-mitochondrial pathways in the SAMHD1 syndrome but in a CKD context without any SAMHD1 or direct genetic linkage.
DOI: 10.32604/biocell.2026.083188
🟢 Low Relevance (Score 3–4)¶
Potential specialty bridges — skim titles
Mitoxyperilysis related signature predicts prognosis innate immune remodeling and myeloid enriched tumor microenvironment states in breast cancer (from oncology)
Li Zhen; Yang Menglei; Li Yongfei — preprint (preprint) 2026
Score: 4/10 | Pathways: NLRP3, cGAS-STING, other
This breast cancer bioinformatics paper touches NLRP3/cGAS-STING and mitochondrial lytic cell death but is oncology-context focused on tumor prognosis signatures rather than SAMHD1 mechanism or family phenotype relevance.
DOI: 10.21203/rs.3.rs-9963383/v1
p38 MAP kinase senses short-chain fatty acids to attenuate Toll-like receptor signaling and intestinal inflammation. (from Gastroenterology/microbiome metabolism)
Wu Qingang; Shi Rongkai; Xiao Liwei; He Xuxiao; Chen Zhuoneng — Science advances 2026
Score: 3/10 | Pathways: cGAS-STING, NF-kB-IKK, other
This paper describes SCFA-mediated suppression of TLR/TBK1-IRF3 signaling in intestinal inflammation, sharing the TBK1-IRF3 node with the BLUE loop but is otherwise unrelated to SAMHD1 or the core interferon-mitochondrial mechanism.
DOI: 10.1126/sciadv.aef1419
TANK potentiates antiviral innate immunity by recruiting deubiquitinase USP46 to activate IKKε. (from Fish virology/comparative immunology)
Li Zhenghao; Yang Can; Shu Juanjuan; Wang Jiaxin; Wang Xinyu — PLoS pathogens 2026
Score: 3/10 | Pathways: NF-kB-IKK
This paper describes IKKε regulation by TANK/USP46 in fish antiviral immunity, a tangential non-mammalian model with only distant relevance to the IKKε/IRF3/NF-kB axis implicated in the SAMHD1 syndrome.
DOI: 10.1371/journal.ppat.1014412
Pathway Coverage This Week¶
treatment-target: 6 paperscGAS-STING: 6 papersNLRP3: 3 papersother: 3 papersNF-kB-IKK: 2 papersurate-NLRP3: 1 papersmTOR-lysosomal: 1 papersJAK-STAT: 1 papersclinical-phenotype: 1 papersAGS-spectrum: 1 papersISG15-mitophagy: 1 papersPOLG-mtDNA: 1 papers