A patient-and-family-led research effort to characterize heterozygous SAMHD1 p.A565T — mechanism, kindred, objectives, and weekly literature surveillance.http://glasscannonfoundation.org/ en Wed, 29 Jul 2026 10:48:59 -0000 Wed, 29 Jul 2026 10:48:59 -0000 1440 MkDocs RSS plugin - v1.19.0 https://glasscannonfoundation.org/assets/logo.svg http://glasscannonfoundation.org/ BIK-cancer IRF7-metabolic ISG15-mitophagy JAK-STAT NF-kB NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype mTOR-lysosomal nucleotide-rewiring treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-07-29</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-5</em></p> <p><strong>Summary:</strong> 12 papers evaluated | 3 high-relevance (≥7) | 8 me...</p> http://glasscannonfoundation.org/blog/2026/07/29/samhd1-research-digest--2026-07-29/ Wed, 29 Jul 2026 10:48:34 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/29/samhd1-research-digest--2026-07-29/ AGS-spectrum JAK-STAT NF-kB Weekly Digest cGAS-STING clinical-phenotype gene-editing treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-07-19</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-5</em></p> <p><strong>Summary:</strong> 7 papers evaluated | 0 high-relevance (≥7) | 3 med...</p> http://glasscannonfoundation.org/blog/2026/07/19/samhd1-research-digest--2026-07-19/ Mon, 27 Jul 2026 07:48:59 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/19/samhd1-research-digest--2026-07-19/ AGS-spectrum ISG15-mitophagy JAK-STAT NF-kB NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype gene-editing pregnancy-fetal treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-07-26</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-5</em></p> <p><strong>Summary:</strong> 31 papers evaluated | 5 high-relevance (≥7) | 16 m...</p> http://glasscannonfoundation.org/blog/2026/07/26/samhd1-research-digest--2026-07-26/ Mon, 27 Jul 2026 07:48:59 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/26/samhd1-research-digest--2026-07-26/ NLRP3 Paper Spotlight VDAC1 cGAS-STING nucleotide-rewiring treatment-target <h1>Mitochondrial dynamics and metabolic regulation in cellular inflammation: From mechanisms to precision therapeutics</h1> <h2>The finding</h2> <p>This is a review artic...</p> http://glasscannonfoundation.org/blog/2026/07/18/mitochondrial-dynamics-and-metabolic-regulation-in-cellular-inflammation/ Sun, 19 Jul 2026 06:47:28 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/18/mitochondrial-dynamics-and-metabolic-regulation-in-cellular-inflammation/ Paper Spotlight dNTPase treatment-target <h1>Transition Metal Activation Reframes SAMHD1 Regulation</h1> <h2>The finding</h2> <p>Using selective metal enrichment, spectroscopy, biochemical reconstitution, and kine...</p> http://glasscannonfoundation.org/blog/2026/07/18/transition-metal-activation-reframes-samhd1-regulation/ Sun, 19 Jul 2026 06:47:28 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/18/transition-metal-activation-reframes-samhd1-regulation/ AGS-spectrum IRF7-metabolic ISG15-mitophagy JAK-STAT NF-kB NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype dNTPase gene-editing mTOR-lysosomal nucleotide-rewiring treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-07-18</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-5</em></p> <p><strong>Summary:</strong> 35 papers evaluated | 6 high-relevance (≥7) | 17 m...</p> http://glasscannonfoundation.org/blog/2026/07/18/samhd1-research-digest--2026-07-18/ Sat, 18 Jul 2026 07:57:05 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/18/samhd1-research-digest--2026-07-18/ Paper Spotlight <h1>cGAS inhibitor IMSB301 modifies interferon signalling in peripheral mononuclear cells of SAMHD1 genetic interferonopathy in vitro</h1> <h2>The finding</h2> <p>Using si...</p> http://glasscannonfoundation.org/blog/2026/07/09/cgas-inhibitor-imsb301-modifies-interferon-signalling-in-peripheral/ Mon, 13 Jul 2026 08:13:40 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/09/cgas-inhibitor-imsb301-modifies-interferon-signalling-in-peripheral/ Paper Spotlight <h1>One mutation, divergent journeys: expanding the clinical spectrum of homozygous SAMHD1 deficiency in childhood</h1> <h2>The finding</h2> <p>This retrospective case seri...</p> http://glasscannonfoundation.org/blog/2026/07/09/one-mutation-divergent-journeys-expanding-the-clinical-spectrum/ Mon, 13 Jul 2026 08:13:40 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/09/one-mutation-divergent-journeys-expanding-the-clinical-spectrum/ Paper Spotlight <h1>From protector to perpetrator: The cGAS-STING pathway at the intersection of neurodegeneration and neuroinflammation</h1> <h2>The finding</h2> <p>This is a review arti...</p> http://glasscannonfoundation.org/blog/2026/07/09/from-protector-to-perpetrator-the-cgas-sting-pathway/ Mon, 13 Jul 2026 08:13:40 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/09/from-protector-to-perpetrator-the-cgas-sting-pathway/ Paper Spotlight <h1>Mitochondrial DNA and Mitochondrial-Derived Vesicles as Immunometabolic Modulators of Innate Immunosurveillance through Control of the Mitochondrial Permea...</h1> http://glasscannonfoundation.org/blog/2026/07/13/mitochondrial-dna-and-mitochondrial-derived-vesicles-as-immunometabolic/ Mon, 13 Jul 2026 08:13:40 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/13/mitochondrial-dna-and-mitochondrial-derived-vesicles-as-immunometabolic/ Paper Spotlight <h1>Recent Insights into Mitochondrial Dysfunction-Driven Cellular Senescence in Chronic Kidney Disease</h1> <h2>The finding</h2> <p>This appears to be a review article (t...</p> http://glasscannonfoundation.org/blog/2026/07/13/recent-insights-into-mitochondrial-dysfunction-driven-cellular-senescence/ Mon, 13 Jul 2026 08:13:40 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/07/13/recent-insights-into-mitochondrial-dysfunction-driven-cellular-senescence/ AGS-spectrum IRF7-metabolic ISG15-mitophagy JAK-STAT Monthly Synthesis NLRP3 POLG-mtDNA VDAC1 cGAS-STING clinical-phenotype mTOR-lysosomal poliosis-neural-crest treatment-target <h1>SAMHD1 Research Digest — 2026-04-22</h1> <p><em>Generated by samhd1_monitor | Model: claude-haiku-4-5-20251001</em></p> <p><strong>Summary:</strong> 41 papers evaluated | 28 high-relevance ...</p> http://glasscannonfoundation.org/blog/2026/04/01/samhd1-research-digest--2026-04-22/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/04/01/samhd1-research-digest--2026-04-22/ IRF7-metabolic ISG15-mitophagy JAK-STAT ME-CFS NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype mTOR-lysosomal treatment-target <h1>SAMHD1 Research Digest — 2026-04-22</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 18 papers evaluated | 6 high-relevance (≥7) | 7 ...</p> http://glasscannonfoundation.org/blog/2026/04/22/samhd1-research-digest--2026-04-22/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/04/22/samhd1-research-digest--2026-04-22/ AGS-spectrum IRF7-metabolic ISG15-mitophagy JAK-STAT ME-CFS NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype dNTPase mTOR-lysosomal pregnancy-fetal treatment-target <h1>SAMHD1 Research Digest — 2026-04-26</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 10 papers evaluated | 4 high-relevance (≥7) | 5 ...</p> http://glasscannonfoundation.org/blog/2026/04/26/samhd1-research-digest--2026-04-26/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/04/26/samhd1-research-digest--2026-04-26/ BIK-cancer NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype dNTPase treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-05-03</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 5 papers evaluated | 3 high-relevance (≥7) | 1 m...</p> http://glasscannonfoundation.org/blog/2026/05/03/samhd1-research-digest--2026-05-03/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/05/03/samhd1-research-digest--2026-05-03/ AGS-spectrum BIK-cancer IRF7-metabolic ISG15-mitophagy JAK-STAT ME-CFS NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype mTOR-lysosomal treatment-target <h1>SAMHD1 Research Digest — 2026-05-10</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 37 papers evaluated | 12 high-relevance (≥7) | 2...</p> http://glasscannonfoundation.org/blog/2026/05/10/samhd1-research-digest--2026-05-10/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/05/10/samhd1-research-digest--2026-05-10/ BIK-cancer IRF7-metabolic ISG15-mitophagy JAK-STAT ME-CFS NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype dNTPase mTOR-lysosomal pregnancy-fetal treatment-target <h1>SAMHD1 Research Digest — 2026-05-17</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 12 papers evaluated | 7 high-relevance (≥7) | 3 ...</p> http://glasscannonfoundation.org/blog/2026/05/17/samhd1-research-digest--2026-05-17/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/05/17/samhd1-research-digest--2026-05-17/ AGS-spectrum BIK-cancer IRF7-metabolic ISG15-mitophagy JAK-STAT ME-CFS NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype dNTPase mTOR-lysosomal treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-05-31</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 44 papers evaluated | 24 high-relevance (≥7) | 9...</p> http://glasscannonfoundation.org/blog/2026/05/31/samhd1-research-digest--2026-05-31/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/05/31/samhd1-research-digest--2026-05-31/ AGS-spectrum BIK-cancer IRF7-metabolic ISG15-mitophagy JAK-STAT ME-CFS NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype dNTPase mTOR-lysosomal treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-06-07</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 21 papers evaluated | 9 high-relevance (≥7) | 6 ...</p> http://glasscannonfoundation.org/blog/2026/06/07/samhd1-research-digest--2026-06-07/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/06/07/samhd1-research-digest--2026-06-07/ AGS-spectrum IRF7-metabolic ISG15-mitophagy JAK-STAT ME-CFS NLRP3 POLG-mtDNA VDAC1 Weekly Digest cGAS-STING clinical-phenotype dNTPase mTOR-lysosomal pregnancy-fetal treatment-target urate-NLRP3 <h1>SAMHD1 Research Digest — 2026-06-14</h1> <p><em>Generated by samhd1_monitor | Model: claude-sonnet-4-6</em></p> <p><strong>Summary:</strong> 41 papers evaluated | 12 high-relevance (≥7) | 1...</p> http://glasscannonfoundation.org/blog/2026/06/14/samhd1-research-digest--2026-06-14/ Mon, 13 Jul 2026 07:56:20 +0000 The Glass Cannon Projecthttp://glasscannonfoundation.org/blog/2026/06/14/samhd1-research-digest--2026-06-14/