SAMHD1 Research Digest — 2026-08-19¶
Generated by samhd1_monitor | Model: claude-sonnet-5
Summary: 13 papers evaluated | 2 high-relevance (≥7) | 8 medium (5–6) | 3 low (3–4) | 0 scored <3
🔴 High Relevance (Score 7–10)¶
Auto-added to Zotero (threshold ≥6)
A genome-wide map of the genetic network in monocytes that regulates type I interferon induction by the cGAS-STING pathway. (from functional genomics/CRISPR screening)
Thomsen Emil Aagaard; Zhao Jian; Narita Ryo; Davis Luther J; Olagnier David — Science signaling 2026
Score: 7/10 | Pathways: cGAS-STING, treatment-target, NF-kB-IKK
This CRISPR screen maps genetic regulators of cGAS-STING-driven IFNB1 induction in monocytes, directly relevant to the BLUE pathway (cGAS-STING-IRF3-IFN-I) implicated in SAMHD1 haploinsufficiency and identifies novel druggable nodes (e.g., TBK1/HDAC3) for interferonopathy therapy.
DOI: 10.1126/scisignal.adx3808
Type I Interferonopathies in the Differential Diagnosis of Vasculitis: A Comprehensive Review. (from Rheumatology/vasculitis)
Gürbüz Nida; Ismayilova Shams; Ahmadova Gulnar; Çiftçi Rena; Aksu Güzide — Journal of visualized experiments : JoVE 2026
Score: 7/10 | Pathways: cGAS-STING, JAK-STAT, AGS-spectrum, treatment-target, clinical-phenotype
This review directly covers SAMHD1 as a monogenic type I interferonopathy gene within the cGAS-STING/JAK-STAT axis, discusses interferon gene signature diagnostics and JAK inhibitor therapy, and links IFN-I dysregulation to vasculitic/autoimmune phenotypes relevant to the family's rheumatologic and autoimmune manifestations, though it does not focus specifically on SAMHD1 A565T.
DOI: 10.3791/71286
🟡 Medium Relevance (Score 5–6)¶
Score ≥6 auto-added to Zotero; lower scores: review manually
Atractylodes macrocephala Koidz. Polysaccharides Alleviate Liver Fibrosis in Association With Suppression of cGAS-STING Signaling and Mitochondrial Apoptosis. (from Hepatology/ethnopharmacology)
Wu Jiali; Hu Xianzhe; Liu Jing; Peng Hongye; Chen Bo — Journal of ethnopharmacology 2026
Score: 6/10 | Pathways: cGAS-STING, NLRP3, treatment-target
Demonstrates a natural compound suppressing cGAS-STING-NLRP3 signaling and mitochondrial danger signaling to reduce liver fibrosis, directly relevant to the BLUE/Loop A axis and NF-κB-NLRP3 priming mechanism central to the disease model, though it is in a non-SAMHD1 liver fibrosis context.
DOI: 10.1016/j.jep.2026.122313
The mitophagy-inflammasome axis: a shared pathological hub in Alzheimer's and Parkinson's diseases. (from neurology/neurodegeneration)
Long Wei; Yuan Mengqin; Wang Sirui; Tan Xinyue; Gao Li-Chen — Translational neurodegeneration 2026
Score: 6/10 | Pathways: NLRP3, mito-ROS-NF-kB, treatment-target
Reviews mitophagy-inflammasome crosstalk (ROS/mtDNA-driven NLRP3 activation and mitophagy suppression) that parallels the PURPLE/RED/Loop B mechanisms in the SAMHD1 syndrome, though focused on neurodegeneration rather than SAMHD1 directly.
DOI: 10.1186/s40035-026-00578-w
PPARα deficiency exacerbates atherosclerosis progressing through enhancing pTh17 cells-macrophage crosstalk. (from Cardiology/vascular immunology)
Ren Tong; Jiang Xilin; Wu Jianfeng; Yan Changsheng; Peng Lu — 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, other
Demonstrates mtDNA leakage activating the cGAS-STING axis to drive pathogenic immune cell differentiation and inflammation in atherosclerosis, mechanistically parallel to the BLUE loop mitochondrial-to-cGAS-STING signaling in SAMHD1 haploinsufficiency though in a distinct disease context.
DOI: 10.1016/j.ejphar.2026.179247
Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission. (from Reproductive toxicology/gynecology)
Xu Chenhui; Deng Haochu; Tian Xue; Ma Shuang; Kong Yuebing — 2026
Score: 6/10 | Pathways: cGAS-STING, other
Demonstrates a toxicant-induced mitochondrial fission-mtDNA leakage-cGAS-STING-senescence axis mechanistically analogous to the disease's BLUE pathway (VDAC1/mtDNA/cGAS-STING) though in a reproductive rather than immune context.
DOI: 10.1007/s11010-026-05696-7
Minimally invasive extracorporeal circulation protects against postoperative pulmonary endothelial injury in elderly cardiac surgery via suppressing the C5a-mtDNA-cGAS-STING axis: a mechanistic randomized controlled trial. (from Cardiothoracic surgery / perioperative critical care)
Zhao Yun; Wang Jiaxing; Yang Zhaohua; Ma Wenrui; Wang Chunsheng — 2026
Score: 6/10 | Pathways: cGAS-STING, treatment-target, other
Demonstrates mtDNA release triggering cGAS-STING activation and endothelial injury in a surgical inflammation model, mechanistically parallel to the BLUE/mitochondrial-cGAS-STING axis in SAMHD1 haploinsufficiency though not disease-specific.
DOI: 10.1016/j.intimp.2026.117281
Engineered Exosome-Mediated FIH-1 Delivery for Targeted Therapy of Hyperuricemic Nephropathy by Inhibiting NF-κB/NLRP3 Inflammasome Signaling and Restoring Autophagic Homeostasis. (from Nephrology/regenerative medicine (exosome-based nanotherapeutics))
Xiao Ting; Liu Yu; He Zhe; Yang Ailing; Li Jing — Advanced healthcare materials 2026
Score: 6/10 | Pathways: urate-NLRP3, NF-kB-NLRP3-priming, NLRP3, treatment-target, mTOR-lysosomal
Demonstrates uric acid/MSU-driven NF-κB/NLRP3 activation and autophagy restoration in nephropathy, directly paralleling the GOLD gout/urate-NLRP3 axis and NF-κB priming crosstalk relevant to SAMHD1-driven interferon-mitochondrial disease, though it is a nephrology/regenerative-medicine context without SAMHD1 linkage.
DOI: 10.1002/adhm.71602
Mitochondrial Dysfunction as a Central Hub of Aging: From Molecular Cascades to Inter-Organ Communication Networks. (from Gerontology/aging biology)
Han Chaodong; Zhang Zilian; Song Yafeng — Gerontology 2026
Score: 5/10 | Pathways: cGAS-STING, NLRP3, mito-ROS-NF-kB, treatment-target
This general aging review covers cGAS-STING/NLRP3-driven inflammation from mitochondrial dysfunction and mitokine signaling, mechanistically overlapping with the Purple/Blue/Gold loops but without any SAMHD1, dNTP, or disease-specific data.
DOI: 10.1159/000553430
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells. (from gene therapy / synthetic biology engineering)
Jung Hyuncheol; Devant Pascal; Ching Carter; Ota Mineto; Dann Emma — Nature biotechnology 2026
Score: 5/10 | Pathways: gene-therapy-delivery, treatment-target
This paper describes a VLP-based CRISPR/base-editing delivery platform for primary human myeloid cells, relevant as a potential future correction/delivery strategy for SAMHD1 immune-cell mutations but not directly addressing SAMHD1 or its interferon-mitochondrial mechanism.
DOI: 10.1038/s41587-026-03258-2
🟢 Low Relevance (Score 3–4)¶
Potential specialty bridges — skim titles
Lactate oxidase-engineered manganese layered double hydroxide nanoplatform amplifies cGAS-STING activation for tumor immunotherapy. (from Nanomedicine/oncology)
Cai Feng; Jiang Dengsheng; Geng Mingzhe; Xu Hongbo; Song Shilong — 2026
Score: 4/10 | Pathways: cGAS-STING, treatment-target
Describes cGAS-STING activation via mtDNA release and oxidative mitochondrial damage in a tumor immunotherapy nanoplatform, mechanistically touching the pathway but in an oncology-engineering context unrelated to SAMHD1 haploinsufficiency or its downstream family phenotypes.
DOI: 10.1016/j.ijbiomac.2026.153862
Astragaloside IV Protects against PM2.5-Induced Spermatocyte Injury via the cGAS-STING/Nrf2/HMOX1 Axis. (from reproductive toxicology/andrology)
Jin Jin; Zhang Congxue — Reproductive toxicology (Elmsford, N.Y.) 2026
Score: 4/10 | Pathways: cGAS-STING, treatment-target
This paper demonstrates cGAS-STING pathway activation and pharmacologic suppression (via AS-IV) in a PM2.5-induced spermatocyte toxicity model, showing mechanistic overlap with the interferon arm of the syndrome but in an unrelated reproductive toxicology context without SAMHD1 or mitochondrial dNTP linkage.
DOI: 10.1016/j.reprotox.2026.109328
Sex-sikpecific associations between serum uric acid and chronic rhinosinusitis: a retrospective case-control study. (from Otolaryngology/Rheumatology (uric acid metabolism))
Zhou Jiaxin; Wu Fan; Wang Chang; Kong Haobo; Liu Yehai — Frontiers in allergy 2026
Score: 3/10 | Pathways: urate-NLRP3
Paper links serum uric acid to chronic rhinosinusitis via sex-specific effects, touching the GOLD pathway (uric acid/MSU-NLRP3 axis) only tangentially without any SAMHD1, interferon, or mitochondrial mechanism.
DOI: 10.3389/falgy.2026.1870468
Pathway Coverage This Week¶
treatment-target: 11 paperscGAS-STING: 9 papersNLRP3: 4 papersother: 3 papersmito-ROS-NF-kB: 2 papersurate-NLRP3: 2 papersNF-kB-IKK: 1 papersJAK-STAT: 1 papersAGS-spectrum: 1 papersclinical-phenotype: 1 papersNF-kB-NLRP3-priming: 1 papersmTOR-lysosomal: 1 papersgene-therapy-delivery: 1 papers